Celiac disease

Question 1

What is celiac disease?

Answer 1

Maladaptive immune response to gluten

Question 2

What are the risk factors of celiac disease?

Answer 2

(Genetic) HLA DQ2, QD6

(Autoimmune disease) Dermatitis herpatiformis

Question 3

What are the clinical features of celiac disease?

Answer 3

Smelly stool
Steatorrhoea 
Diarrhea 
Angular stomatitis 
Weight loss, fatigue

Question 4

How is celiac disease diagnosed?

Answer 4

(FBC) reduced hemoglobin, low B12, low ferritin, high RCDW
(IgA) positive IgA antibody
Duodenal biopsy showing villous atrophy and crypt hyperplasia

Question 5

What is the treatment for celiac disease?

Answer 5

Gluten free diet

Question 6

What are the complications of celiac disease?

Answer 6

Anemia, dermatitis herpetiformis, osteopenia/osteoporosis

Increase risk of lymphoma, gastric, esophageal, colorectal cancer