Cell Adaptations Flashcards
What is a protein misfolding disorder?
Amyloid
Misfolding of soluble and functional proteins, converting them into _________ and __________ aggregates
Insoluble
Nonfunctional
What are the 3 locations amyloids are commonly found?
Liver
Kidney
Vessel walls
The gross appearnce of Amyloidosis =
_________ in tissue/organ size
Paleness
Increase
What type of Amyloidosis:
Is systemic and derived from serum amyloid A?
AA
Where is AA produced in cases of chronic inflammation?
Hepatocytes
What type of Amyloidosis is commonly deposited in the kidney and liver?
AA
What type of Amyloidosis:
Localized and derived from immunoglobulin light chains?
AL
AL Amyloidosis is commonly deposited adjacent to _______ cell tumors
Plasma
What type of Amyloidosis is nasal and conjunctival in horses?
AL
What part of the kidney is is hereditary or familial forms of AA Amyloidosis found?
Renal medially interstitium
What is the leakage of plasma proteins into the wall of a blood vessel?
Fibrinoid change
What is septic or immune mediated vasculitis examples of?
Fibrinoid change
What form in tissue at sites of chronic hemorrhage and in atherosclerosis?
Cholesterol clefts
What do cholesterol clefts induce?
Inflammatory response
