Irreversible Cell Injury

Question 1

What are the 3 “points of no returns”

Answer 1

Mitochondrial damage
Entry of calcium
Membrane damage

Question 2

What type of cells of susceptible to hypoxia after 3-5 mins?

Answer 2

Neurons

Question 3

What type of cells of susceptible to hypoxia after 30mins to 2hrs?

Answer 3

Myocardium, hepatocytes, renal epithelium

Question 4

What type of cells of susceptible to hypoxia after many hours?

Answer 4

Fibroblasts, epidermis, skeletal muscle

Question 5

What type of necrosis is this?
Swelling
Rupture of plasma membrane and organelles
Rupture of nucleus
Mitochondria are swollen and develop amorphous densities

Answer 5

Ultrasound oncotic

Question 6

What type of necrosis are these microscopic characteristics of?
Hyperseosinophilic cytoplasm
Pyknosis
Karyorrhexis
Karyolysis

Answer 6

Oncotic