Cell-cell and cell-matrix interactions

Question 1

What is the ECM composed of

Answer 1

Hyaluronan, collagen, elastic fibers and proteoglycans

Question 2

What separates the stroma from the epithelium

Answer 2

basal lamina

Question 3

What composes the basal lamina around blood vessels

Answer 3

collagen XVIII

Question 4

Menke’s disease

Answer 4

defective copper transportation (collagen disorder–no crosslinking)

Question 5

Alport syndrome

Answer 5

missing type IV collagen (basal lamina))

Question 6

Good pasture syndrome

Answer 6

missing type IV collagen (basal lamina)

Question 7

What are some of proteoglycan’s functions

Answer 7

hydration regulatioon, impact resistance, and growth factor and cytokin reservoir

Question 8

what is CCN5 and what does it do

Answer 8

it is a matricellular protein that inhibits smooth muscle proliferation

Question 9

what are fibroids

Answer 9

smooth muscle benign growths

Question 10

what do matricellular proteins bind

Answer 10

collagen

Question 11

Glanzmann’s

Answer 11

defective fibrin-integrin association resulting in no clotting ability

Question 12

What connects elastin together to increase its flexibility

Answer 12

fibrillin

Question 13

Marfan’s syndrome involves defective

Answer 13

fibrillin