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Flashcards in Cell signalling Deck (10):
1

Modes of communication

-direct cell-cell signalling(really short distance)
-neurotransmitters-
-signaling by secreted molecules(long - distance)

2

What is endocrine signalling

-signalling by secreted molecules
-where endocrine cells secrete hormones that are carried through the circulation to act on target cells

3

What are the derivatives of cholesterol

-steroid hormones are derivatives of cholesterol
-the hydrophobic nature allows diffusion across membranes

4

WHat happens in the presence of hormones in cell signalling

changes conformation of receptor, displacing HDAC (corepressor) for HAT (coactivator) that is bound to the thyroid hormone receptor

5

What are thyroid hormones

non steroid chemical hormones that bind DNA in an inactive form that becomes active when bound with hormone

6

Paracrine signalling

short distance communication mode in which molecule released by one cells acts on target cells

7

what is Paracrine signalling

short distance communication mode (neurotransmitters) in which molecule released by one cells acts on target cells

8

Neurotransmitters as paracrine ligands

-hydrophilic
-release stimulated by action potential in neuron
-bind cell surface receptors
-depolarization
-also bind G protein couples receptors

9

Nitric acid as paracrine ligands

-difuses out of cell freely
-extremely unstable
-induction of NO synthesis in endothelial cells of blood vessels by release of acetylcholine from neurons
-diffusion of NO to surrounding smooth muscles

10

what can limit a ligand's effect on target cells

-chemical nature of ligand
-distance from target cell
-receptors on target cell
-intercellular molecules