Cell Wall Inhibitors

Question 1

Natural Penecillins

Clinical Use

Answer 1

Common streptococci, pneumocci, enterocci, meningococci, treponema pallidum

Question 2

Natural Penecillins

Toxicity

Answer 2

Hypersensitivity
Hemolytic Anemia
Cross Sensitive

Question 3

Penecillinase Resistant Penecillins

Answer 3

Nafcillin, Methicillin, Dicloxacillin

Question 4

Penecillinase Resistant Penecillins

Mechanism

Answer 4

Same as Penecillins

Narrow spec

Question 5

Penecillinase Resistant Penecillins

Clinical Use

Answer 5

Staphylococcus (naf for staph)

Question 6

Penecillinase Resistant Penecillins

Toxicity

Answer 6

Headache

Metallic Taste

Question 7

Aminopenecillins

Answer 7

Amoxicillin

Ampicillin

Question 8

Amino penicillins

Mechanism

Answer 8

Same as pen.

Broad spec with clavulanate

Question 9

Aminopenecillins

Clinical Use

Answer 9

Broad spec

DOC for Listeria monocytogenes, enterocci, and prophy for infective endocarditis

Question 10

Amino penicillins

Toxicity

Answer 10

Hypersensitivity
Ampicillin Rash
Pseudo membranous colitis

Question 11

Anti-pseudomonal Penecillins

Answer 11

Piperacillin
Ticarcillin
CarbenIcillin

Question 12

Anti-pseudomonas Penecillins

Mechanism

Answer 12

Same as pen

Extended spec

Question 13

Anti-pseudomonas Penecillins

Clinical use

Answer 13

Pseudomonas and gram - rods

Synergy with aminoglycoside so

Question 14

Anti pseudomonal Penecillins

Toxicity

Answer 14

Hypersensitivity

Question 15

Cephalosporins

Mechanism

Answer 15

Penacillinase resistant

Question 16

Cephalasporins

Clinical Use

Answer 16

1st gen - PEK (proteus miribalis, E. coli, klebsiella pneum.)
2nd gen - HENPEKS (H. Influenza, Enterobacter aerogels, neisseria, same 3, Seratia)
3rd gen - gram+/- cocci, gram - rod, meningitis (crosses BBB), anaerobes, gonococci, pseudomonas
4th gen - pseudomonas
5th gen - covers MRSA

Question 17

Cephalasporins

Toxicity

Answer 17

Hypersensitivity
Increases toxicity of aminoglycosides
Pseudo membranous colitis

Question 18

Aztreonam
(Monobactam)
Mechanism

Answer 18

Same as pen. But binds to PBP-3
Penecillinase resistant
Renally excreted

Question 19

Monobactam

Clinical use

Answer 19

Gram - Aerobes

(SPiKe) Seratia, Pseudomonas, Klebsiella

Question 20

Monobactam

Toxicity

Answer 20

Pseudomembranous Colitis
Hematological disorders
Fever
Diahrrea 
Cellulitis

Question 21

Carbapenems

Mechanism

Answer 21

Same as pen.
Broad spec
Penecillinase resistant

Question 22

Carbapenems

Clinical use

Answer 22

+ cocci, - rods

DOC for enterobacteria

Question 23

Carbapenems

Toxicity

Answer 23

CNS toxicity
GI
Skin rash
Skeletal muscle toxicity

Question 24

Vancomycin

Mechanism

Answer 24

Inhibits cell wall formation by binding d-ala d-ala

Question 25

Vancomycin | Clinical Use

Answer 25

Multidrug resistant gram + | Staph aureus, Clostridium difficile

Question 26

Vancomycin | Toxicity

Answer 26

Nephrotoxicity Ototoxicity Thrombophlebitis Red Man Syndrome

Question 27

Bacitracin | Mechanism

Answer 27

Blocks peptidoglycan synthesis

Question 28

Bacitracin | Clinical use

Answer 28

Topical Antimicrobial

Question 29

Bacitracin | Toxicity

Answer 29

Nephrotoxicity | Ototoxicity

Question 30

Daptomycin | Mechanism

Answer 30

Inserts into cell membrane and forms ion channels

Question 31

Daptomycin | Clinical Use

Answer 31

Vanc and Meth resistant gram +

Question 32

Daptomycin | Toxicity

Answer 32

headache GI insomnia Rhabdomyalasis

Question 33

Beta-lactamase inhibitor/drug combos

Answer 33

Augmentin - Amoxicillin and Clavulanate Unycin - Ampicillin and Sublactam Zosyn - Pipercillin and Tazobactam

Question 34

What is the broadest spectrum antibacterial?

Answer 34

Imipenem

Question 35

What must you administer with Imipenem and why?

Answer 35

Cilistatin - inhibits renal dihydropeptidase 1

Question 36

Which amino penecillin is administered orally?

Answer 36

Amoxicillin

Question 37

Natural Penecillins | Mechanism

Answer 37

``` Bactericidal Inhibits transpeptidase (PBP) Activates autolysins ```