Protein Synthesis Inhibitors

Question 1

Aminoglycosides

Clinical Use

Answer 1

Severe Gram - aerobes

Neomycin enema for bowel surgery

Question 2

Tetracyclines

Clinical Use

Answer 2

VACUUM THe BedRoom
Vibrio cholerae, Acne, Chlamydia, Ureplasma, Urelytica, Mycoplasma Pneumonia, Tuluremia, H. Pylori, Borellia Burgdorferi, Rickettsia

Question 3

Chloramphenicol

Clinical Use

Answer 3

Meningitis (crosses BBB)

Rickettsia in children

Question 4

Clindamycin

Clinical Use

Answer 4

Gram + anaerobes above the diaphragm

Question 5

Macrolides

Clinical Use

Answer 5

URI, pneumonia, STIs, Conunctivitis

Question 6

Linezolid

Clinical Use

Answer 6

Hospital acquired pneumonia
S. Aureus pneumonia
MRSA and VRE

Question 7

Streptogramins

Clinical Use

Answer 7

Bacteremia from VRE
Enterococcus Faceium
VRSA skin infections

Question 8

Mupirocin

Clinical Use

Answer 8

BS g+ and g- topical for skin infections

MRSA and MRSP

Question 9

Aminoglycosides

Toxicity

Answer 9

Nephrotoxicity
Ototoxicity
Teratogenic

Question 10

Tetracyclines

Toxicity and contraindications

Answer 10

Headache
Metallic Taste
Hairy Tongue
Enamel discoloration and weakness
Don't give with alcohol, divalent cations, or to pregnant women

Question 11

Chloramphenicol

Toxicity

Answer 11

Anemia
Hemolytic anemia
Aplastic anemia
Grey baby syndrome
(Conservatively used due to toxicity)

Question 12

Clindamycin

Toxicity

Answer 12

C. Difficile overgrowth
Hematologic problems
Fever
Diarrhea
Cellulitis

Question 13

Macrolides

Toxicity

Answer 13

Safest of all antimicrobials
PIG EAR
Prolonged QT, Increased serum theophyllines, GI discomfort, Eosinophilia, Acute Cholestatic Hepatitis, Rash

Question 14

Linezolid

Toxicity

Answer 14

Bone Marrow Suppression
Avoid if on MOA suppressors
Headache
GI disturbance
Reversible neurotoxicity

Question 15

Streptogramins

Toxicity

Answer 15

Hyperbilirubinemia
Injection site pain and inflammation
Myalgia and Arthralgia

Question 16

Mupirocin

Toxicity

Answer 16

Injection site pain and inflammation

Question 17

Aminoglycosides

Mechanism

Answer 17

Bactericidal
30s subunit
Inhibits initiation, induces misreading, forces early termination

Question 18

Tetracyclines

Mechanism

Answer 18

Bacteriostatic
30s subunit
Doesn’t allow binding of aminoacyl tRNA

Question 19

Chloramphenicol

Mechanism

Answer 19

Bacteriostatic
50s subunit
Prevents peptidyltranferase reaction

Question 20

Clindamycin

Mechanism

Answer 20

Bacteriostatic
50s subunit
Blocks peptide bond formation

Question 21

Macrolides

Mechanism

Answer 21

Bacteriostatic
50s subunit
Inhibits translocation

Question 22

Linezolid

Mechanism

Answer 22

Bacteriostatic

50s subunit

Question 23

Streptogramins

Mechanism

Answer 23

Bacteriostatic

50s subunit

Question 24

Mupirocin

Mechanism

Answer 24

Bactericidal

Inhibits isoleucyl tRNA synthetase

Question 25

What is the broadest spectrum aminoglycoside?

Answer 25

Amikacin

Question 26

Which antibiotic is fecaly eliminated?

Answer 26

Doxycycline

Question 27

Which protein synthesis inhibitor crosses the BBB?

Answer 27

Chloramphenicol

Question 28

Which PSI is absorbed well orally?

Answer 28

Macrolides

Question 29

Which PSI is only give IV?

Answer 29

Streptogramins

Question 30

What should you avoid with mupirocin?

Answer 30

Large coverage of skin areas in patients with renal insufficiency.