Cell Wall Inhibitors I/II, DNA and Metabolic Toxins, Protein Synthesis Inhibitors

Question 1

b-lactams excretion

Answer 1

kidneys

Question 2

early rxn to b-lactams

Answer 2

IgE

Question 3

late rxn to b-lactams

Answer 3

• rash
• immune destruct wbc/rbc/platelets
• serum sickness (Fever, rash (morbilliform), arthritis, glomerulonephritis)

Question 4

main use oxacillin

Answer 4

penicillinase-prod S. aureus

Question 5

ampicillin uses

Answer 5

enterococcus
listeria
some gram - (H. influenza, some E coli, proteus)

Question 6

dental prophylaxis

Answer 6

amoxicillin

Question 7

covers meningitis secondary to listeria

Answer 7

ampicillin

Question 8

amoxicillin + _____ = augmentin

Answer 8

clavulanate (beta-lactamase inhibitor)

good choice for diverticulitis (mixed flora)

Question 9

b-lactams demonstrate ___-dependent killing

Answer 9

time

Question 10

MSSA tx

Answer 10

oxacillin

Question 11

cephalosporin excretion

Answer 11

renal

Question 12

cephalosporin use in pt with penicillin allergy

Answer 12

can use in pt with LATE penicillin allergy (rash)

NEVER use in pt w/ hx of PCN anaphylaxis

Question 13

skin/soft tissue infec

which cephalosporin gen

Answer 13

1st (Cefazolin)

Question 14

activity against B fragilis

Answer 14

2nd gen (Cefoxitin)

Question 15

T/F

ceftaroline cover psuedomonas

Answer 15

F

Question 16

vancomycin excretion

Answer 16

kidneys

Question 17

daptomycin not used in pneumonia why?

Answer 17

inactivated by alveolar surfactant

Question 18

fluroquniolones resistance

Answer 18

active efflux pumps

Question 19

peripheral neuropathy AE

Answer 19

metronidazole

Question 20

tick borne illness agent

Answer 20

doxycycline