Cell Wall Inhibitors ( Polymyxin B) Flashcards
1
Q
Other name of polymixin B
A
Colistin
2
Q
Colistin is ………….
A
Cation polypeptide
3
Q
MOA of Colistin :
A
Bind to phospholipid on the bacterial cell membrane of gram negative bacteria
CELL MEMBRANE NOT CELL WALL
4
Q
Pharmacodynamics of Colistin :
A
1) bactericidal
2) Concentration dependant
5
Q
Antibacterial spectrum of Colistin :
A
Effective against most gram negative bacteria including P.aeruginosa.
6
Q
Adverse effects of Colistin
A
Nephrotoxicity and neurotoxicity
