Cell Wall Inhibitors (Vancomycin )

Question 1

Vancomycin is ………

Answer 1

Tricyclic glycopeptide

Question 2

MOA of vancomycin :

Answer 2

1) binds to peptidoglycan precursors
2) disrupting polymerisation and cross-linking required for maintenance of cell wall integrity.

Question 3

Anti-bacterial spectrum of vancomycin:

Answer 3

Effective against gram-positive bacteria including MRSA and MSSE ( methicillin sensitive staphylococcus epidermidis )

Question 4

Vancomycin pharmacodynamics :

Answer 4

1) bactericidal
2) time- and concentration- dependant antibiotic

Question 5

MOR of vancomycin :

Answer 5

Alteration of binding affinity to peptidoglycan precursors

Question 6

Administration of vancomycin :

Answer 6

Oral and IV

Question 7

Oral vancomycin is used in :

Answer 7

Severe antibiotic associated pseudomembranous colitis

Question 8

IV vancomycin is used in :

Answer 8

1) MRSA skin infections
2) infective endocarditis

Question 9

Adverse effects of vancomycin :

Answer 9

1) Ototoxicity
2) Nephrotoxicity
3) Red man Syndrome