cellular basis of immune response

Question 1

IL-1

Answer 1

B cell—promotes B cell development and Bone marrow maturation
Liver—induces synthesis of acute phase reactant proteins
Hypothalamus—induction of fever
Macrophage and neutrophil activation— ↑expression of ICAM
TH cells—IL-1 produced by APCs stimulates TH cells activation and proliferation
Induces IL-2 receptor expression on TH cells
Induces ↑MHC-II expression on APCs
Promotes IL2 secretion by TH cells

Question 2

IL-2

Answer 2

induces proliferation of activated TH cells, TC cells and some NK cells

Question 3

IL-4

Answer 3

TH cells—promotes TH 2 cell activity and inhibits TH 1 cell
* B cell—promotes B cells activation and proliferation and induces B cell class
* Macrophage and APCs—induce ↑MHC-II expression

Question 4

IL5

Answer 4

Promotes eosinophil growth and differentiation

Question 5

IL-6

Answer 5

IL-1 and TNF like effects (synergistic effect)
* Promotes B cell proliferation and antibody production

Question 6

IL-10

Answer 6

Reduces cytokine production by TH 1 cell

Question 7

IL-12

Answer 7

Promote TH 1 cell induction and inhibit TH 2 activity
Promotes CMI responses NK cell stimulatory factor

Question 8

INTERFERONα-

Answer 8

Antiviral activity

Question 9

INTERFERONβ-

Answer 9

Antiviral activity

Question 10

INTERFERONγ-

Answer 10

• Macrophage—activates the resting macrophages into activated macrophage * B cells—activate B cells to produce IgG * Promotes inflammation of delayed type of hypersensitivity (along with TNF-β)
• TH2 cell—inhibits TH 2 cell proliferation

Question 11

TUMOR NECROSIS FACTOR-α

Answer 11

• IL-1 like effect
• Tumor cells—promote vascular thrombosis and
  tumor necrosis
• Inflammatory cells—induce cytokine secretion * Induces lipolysis, causes extensive weight loss
  associated with chronic inflammation

Question 12

TUMOR NECROSIS FACTOR-β

Answer 12

Tumor cells—similar effect like TNF-α

• Macrophage—enhance phagocytic activity