Cellular Organization (chapter 3) Flashcards
(44 cards)
Cell
smallest living unit
Cytology
study of cells, requires microscope
Two categories of cells
1.sex cells: sperm and oocyte(egg)
2.somatic cells: everything else
Plasma Membrane/Cell Membrane
-mostly phospholipid bilayer: dynami
-6 to 10mm thick
-interface between cell and enviornment
Plasma membrane functions
-physical barrier to maintain homeostasis: separates intracellular contents (cytoplasm) from extracellular fluid
-regulates exchange with environment
-provides sensitivity via receptors: cell communication and signaling, sense change in extracellular environment
-provides structural support: attachment site to hold tissues together
Plasma membrane components
A. phospholipids: self assemble into bilayer
B. cholesterol: resist osmotic lysis: stiffens
C. carbohydrates: linked to other molecules as proteoglycans, glycoproteins, and glycolipids
-carb part protrudes from extracellular side creating outer carb layer called glycocalyx
D. proteins:
-1/2 mass of membrane
-integral proteins: (most common) span width of membrane
-peripheral proteins adhere to inner or outer surface
Functions of glycocalyx
-lubrication and protection
-anchoring and locomotion
-binding specificity (receptor binds ligands)
-self recognition by immune system
Functions of membrane proteins
-anchoring proteins: attachment (both inside and outside)
-recognition proteins: self identification by immune system (glycoproteins)
-enzymes: catalyze rxns in cytosol or extra cellular fluid
-receptors: bind ligands for signaling or import/export (e.g ions, nutrient molecules, hormones, etc)
-carrier proteins: transport solutes in/out
-channels: move ions and H2O in/out
Facilitated diffusion
movement of materials across a membrane by a carrier protein
-substances involved simple sugars and amino acids
Osmosis
diffusion of water molecules across a selectively permeable membrane. Movement occurs toward higher solute concentration because that is where the concentration of water is lower.
-substances involved water only
Diffusion
is the movement of molecules from an area of higher concentration to an area of lower concentration.
-substances involved gasses, small inorganic ions and molecules, lipid soluble materials
Transcription
-making an RNA copy of a DNA gene
-occurs in the nucleus
Translation
making a protein using the mRNA blueprint
-occurs in the cytoplasm on free ribosomes or on fixed ribosomes on the RER
Active Transport
requires proteins that move specific substances across a membrane against their concentration
Endocytosis
packaging of extracellular materials into a vesicle for transport into the cell
Exocytosis
intracellular vesicles fuse with the plasma membrane to release fluids and or solids from the cells
Cytoskeleton
-internal framework
-organizes cell contents and functions
-4 possible types of filaments:
A. Microfilaments
B. Intermediate filaments
C. Microtubules
D. Thick filaments
Centrosome
-located near nucleus
-consists of dense cytoplasm and two centrioles arranged at right angels
-functions as microtubule organizing center
-responsible for assembling spindle apparatus during mitosis
Cilia
-cellular appendages
-contain a microtubule core with cytoplasm covered in plasma membrane
-beating or waving motions
-short, numerous, functio to sweep substances over cell surface
Flagellum
-Very long, singular function to propel cell through environment
Ribosomes
-site of protein synthesis: enzymes to peptide bond amino acids
-2 subunits: large and small both composed of 60% rNA and 40% protein
A. Free ribosomes: in cytoplasm, manufacture proteins for use in cytoplasm
B. Fixed ribosomes: attached to ER, manufacture proteins for export or for in the membrane
Endoplasmic Reticulum
-network of membranes made up of tubes sacs and chambers called cisternae
-attached to the nuclear envelope
-2 forms: RER and SER
Rough ER
-studded with fixed ribosomes
-ribosomes synthesize proteins and feed them into RER cisternae to be modified
-modified proteins put into transport vesicles to go to golgi
-these proteins for exocytosis or use in membrane
Smooth ER
-tubular membranes
-no ribosomes
functions of SER
1. synthesis of phospholipids and cholesterol for membrane
2. synthesis of steroid hormones
3 synthesis and storage of triglycerides
4. synthesis and storage of glycogen
5. storage of Ca2+ ions in muscle cells
6. detoxification/inactivation of drugs in kidney and liver cells