CENTRAL NERVOUS SYSTEM Flashcards
(37 cards)
- Which of the following statements are correct about Thyroglossal duct cyst:
(a) Is usually located the level of or immediately below the hyoid bone.
(b) Accounts for 70 % of all congenital neck anomalies.
(c) Is usually located in the midline.
(d) Typically presents as a painful neck lump.
(e) During embryological development, the thyroid gland migrates down behind the hyoid bone.
Answers:
(a) Correct
(b) Correct
(c) Correct
(d) Not correct
(e) Not correct
Explanation:
The thyroid is gland begins to develop in the third week of gestation as a median outgrowth from the floor of the
primitive pharynx at the level of foramen Caecum which lies at the junction of the anterior two thirds and posterior
third of the tongue.
It descends down on the floor of the mouth, anterior to the hyoid bone, to each its final position in the inferior part of
the neck by 7th week of gestation.
It typically presents as a painless lump. A painful lump can occur if there is imposed infection.
- The following skull foramina transmit the named cranial nerves:
(a) Superior orbital fissure –VIth cranial nerve.
(b) Foramen ovale – orbital division of Vth cranial nerve
(c) Inferior orbital fissure – IIIrd cranial nerve.
(d) Internal auditory meatus – VIIth cranial nerve.
(e) Foramen rotundum – maxillary division of Vth cranial nerve.
Answers:
(a) Correct
(b) Not correct
(c) Not correct
(d) Correct
(e) Correct
Explanation:
The inferior orbital fissure transmits the infraorbital nerve (i.e. continuation of the second division of the fifth cranial
nerve) and emissary veins that drain the inferior ophthalmic vein to the pterygoid plexus.
The foramen ovale transmits the mandibular division of fifth cranial nerve and the accessory meningeal artery.
The internal auditory meatus contains the seventh and eighth cranial nerves as well as the internal auditory artery.
- Which of the following statements are correct about Haemangioblastoma (HB):
(a) The most common site is the spinal cord.
(b) Is the most common primary cerebellar tumor in adults.
(c) Most patients with multiple HBs have von Hippel-Lindau disease
(d) Most HBs have homogeneously solid appearance on MRI.
(e) Most HBs do not enhance after intravenous gadolinium
Answers:
(a) Not correct
(b) Correct
(c) Correct
(d) Not correct
(e) Not correct
Explanation:
HB is a vascular tumour of the CNS. It occurs most often in the cerebellum, where it is the most common primary
neoplasm in adults. HBs are less commonly seen in the spinal cord and rarely occur elsewhere in the CNS .
Cerebellar hemangioblastomas are traditionally classified into 4 types. Type one is a simple cyst without
macroscopic nodule. Type II ( most common ) is a cyst with a mural nodule. Type III are solid tumours and type IV are
solid tumours with small internal cysts.
- Which of the following statements are correct about Neurofibromatosis type 1 (NF-1):
(a) Plexiform neurofibromas are pathognomonic for NF-1
(b) Has an incidence of around 1 in 3000
(c) 1-10 % of neurofibromas undergo malignant transformation.
(d) Anterior vertebral scalloping is characteristic.
(e) Pulmonary parenchymal abnormalities are seen in up to 20 % of cases.
Answers:
(a) Correct
(b) Correct
(c) Correct
(d) Not correct
(e) Correct
Explanation:
Neurofibromatosis shows posterior scalloping and enlargement of intervertebral foramen due to dural ectasia and
neurofibroma of nerve roots.
Other features are ribbon ribs, bowing of long bones, pseudoarthrosis and cystic osteolytic lesions.
- Which of the following statements are correct about MRI features of multiple sclerosis:
(a) Corpus callosum lesions are best visualized on axial view.
(b) T2W spin echo is superior to FLAIR for posterior fossa lesions.
(c) Whiter matter lesions are more conspicuous than grey matter lesions.
(d) Ring enhancement on post gadolinium T1W MRI suggests an alternative diagnosis.
(e) 10-15 % of patients have lesions limited to the spinal cord.’
Answers:
(a) Not correct
(b) Correct
(c) Correct
(d) Not correct
(e) Correct
Explanation:
MS plaques are classically seen in periventricular and juxtacortical white matter. Involvement of corpus callosum is
characteristic and is best seen on Sagittal images.
Both solid and ring enhancement may occur. Incomplete ring enhancement is seen in larger MS plaques
- Which of the following statements are correct about Chiari malformation:
(a) In normal physiology, cerebellar tonsils descend with increasing age.
(b) Cerebellar tonsils laying 3 mm below the foramen magnum is a normal finding in the second decade.
(c) Is usually associated with other congenital brain anomalies.
(d) Is rarely associated with spinal cord lesions.
(e) Is associated with Klippel-Feil anomaly (fused cervical vertebrae).
Answers:
(a) Not correct
(b) Correct
(c) Not correct
(d) Not correct
(e) Correct
Explanation:
In normal physiology, cerebellar tonsils ascend with increasing age. In Chiari 1, there is downward displacement of
tonsils below the foramen magnum by more than 5 mm.
It is usually associated with spinal cord and skull base abnormalities rather than other brain anomalies
- Which of the following statements are correct about Tuberous sclerosis:
(a) Cortical tubers enhance following intravenous contrast in the majority of cases on CT.
(b) Subependymal nodule enhancement indicates malignant transformation.
(c) Subependymal giant cell astrocytoma is seen in the 10-20 % of cases.
(d) Renal angiomyolipomas are seen in 5-10% of cases.
(e) Cardiac rhabdomyoma is a recognized manifestation
Answers:
(a) Not correct
(b) Not correct
(c) Correct
(d) Not correct
(e) Correct
Explanation:
In tuberous sclerosis, the cortical tubers are seen in 95% of patients although enhancement is seen in less than 5% of tubers.
30-80% of all subependymal nodules enhance after intravenous contrast but it does not indicate malignant
transformation.
Renal Angiomyolipomas are seen in 40-80% of cases of tuberous sclerosis.
- Which of the following statements are correct about Subarachnoid hemorrhage (SAH):
(a) A normal CT within 24 h of onset of symptoms excludes SAH.
(b) The most common etiology is trauma.
(c) Focal interhemispheric blood suggests an anterior communicating artery aneurysm rupture.
(d) Blood in the 4th ventricles is a typical feature of posterior communicating artery aneurysm rupture.
(e) SAH detected on CT more than 1 week after the initial hemorrhage suggests recurrent bleeding.
Answers:
(a) Not correct
(b) Not correct
(c) Correct
(d) Not correct
(e) Correct
Explanation:
A ruptured intracranial aneurysm is the most common aetiology and accounts for 72% of cases of SAH.
A normal CT within 24 hours can exclude SAH in 90% of cases but not always.
4th ventricle blood is common with posterior inferior cerebellar artery aneurysms.
- Which of the following statements are correct about Congenital cholesteatoma of the middle ear:
(a) 80 % of middle ear cholesteatoma are congenital in origin
(b) Facial nerve palsy is a recognized complication.
(c) The anterosuperior aspect of the middle ear is a typical location.
(d) MRI is the imaging modality of choice.
(e) Is associated with poorly pneumatised mastoid air cells:
Answers:
(a) Not correct
(b) Correct
(c) Correct
(d) Not correct
(e) Not correct
Explanation:
Congenital cholesteatoma accounts for 2% of all cholesteatomas and are clinically differentiated from acquired as
they occur behind an intact tympanic membrane in patients without a history of tympanic perforation or otorrhoea.
CT provides more accurate information regarding the mass and bony structures than MRI.
Well pneumatised mastoid air cells are seen in congenital cholesteatomas than in acquired
- Characteristic features of Herpes simplex encephalitis (HSE) in adults include:
(a) Unilateral cerebral involvement
(b) Infection by HSV type II
(c) Untreated infection has a mortality rate of 50-70 %
(d) Gyriform enhancement on contrast enhanced CT
(e) High signal in the cingulated gyrus on T2W MRI
Answers:
(a) Not correct
(b) Not correct
(c) Correct
(d) Correct
(e) Correct
Explanation:
Neonatal herpes is caused by HSV II and herpes in adults is caused by HSV I.
In adults, herpes initiates as unilateral involvement of limbic system ( temporal bones, insular cortex, subfrontal area
and cingulated gyri) but eventually follows bilaterally.
CT performed early in the course of illness may be normal or only subtly normal.
- Concerning the submandibular space:
(a) Anteriorly there is free communication between the submandibular space and the sublingual space.
(b) The superficial lobe of the submandibular gland lies inferolateral to mylohyoid.
(c) Intraglandular ducts are seen as linear hypoechoic structures on ultrasound.
(d) Stenson’s duct exits in the floor of the mouth at the base of the frenulum.
(e) As with the parotid gland, normal lymph nodes are found within the submandibular gland
Answers:
(a) Not correct
(b) Correct
(c) Not correct
(d) Not correct
(e) Not correct
Explanation:
Submandibular and sublingual space communicates posteriorly.
Intraglandular ducts are seen as linear hyperechoic structures on USG.
Wharton’s duct exits in the floor of mouth at the base of frenulum.
Normal lymph nodes are not found in the submandibular gland.
- Which of the following statements are correct about Pyogenic brain abscesses:
(a) Most commonly occur secondary to a generalised septicaemia.
(b) Typically occur at the corticomedullary junction.
(c) On CT have a smooth regular wall with relative thinning of the lateral wall.
(d) Are more common in the occipital lobes than the frontal lobes.
(e) The most common causative organism is Staphylococcus.
Answers:
(a) Not correct
(b) Correct
(c) Not correct
(d) Not correct
(e) Not correct
Explanation:
32% of the pyogenic brain abscesses could be due to generalised septicaemia for example, from a lung abscess or
pneumonia. However 41% occur secondary to extension from paranasal sinus infection.
The occur most commonly in the frontal lobes than in the occipital lobes.
On CT there is a relative thinning of the medial wall due to would blood supply of white matter which leads to the
rupture of the abscess into the ventricular system.
Most common causative organism is streptococcus.
- Regarding subarachnoid haemorrhage:
(a) It occurs secondary to arteriovenous malformation in 10% of cases.
(b) It is associated with subdural haemorrhage in 20% of cases.
(c) 15-20% of patients will have multiple aneurysms.
(d) MRI is the best modality for detecting early subarachnoid haemorrhage.
(e) Cerebral vasospasm is maximal from 48 to 72 hours after the event.
Answers:
(a) Correct
(b) Not correct
(c) Correct
(d) Not correct
(e) Not correct
Explanation:
Subarachnoid haemorrhage is associated with subdural haemorrhage in 5% of the cases.
Initially subarachnoid haemorrhage may not be seen on MRI, hence CT is used for earlier detection of subarachnoid
haemorrhage.
Cerebral vasospasm occurs at 5-17 days after the event of subarachnoid haemorrhage.
- Concerning orbital mass lesions:
(a) 50% of patients with optic nerve glioma have neurofibromatosis Type 1.
(b) On MRI, retinoblastoma usually enhances following intravenous gadolinium.
(c) Rhabdomyosarcoma of the orbit presents with rapid onset proptosis and visual loss.
(d) Inflammatory orbital pseudotumour involves the muscle tendons.
(e) 60-80% of children with retinoblastoma have bilateral tumours.
Answers:
(a) Not correct
(b) Correct
(c) Not correct
(d) Correct
(e) Not correct
Explanation:
25% of the patients with optic nerve glioma have neurofibromatosis type I however only 15% of the patients with
neurofibromatosis type I have optic nerve glioma.
In the rhabdomyosarcoma of the orbit, there is rapid onset of proptosis however vision is spared.
Only 20-40% of retinoblastomas occur bilaterally in children.
- Which of the following statements are correct about pineal region masses:
(a) Pineoblastomas are categorised as part of the primitive neuroectodermal tumour group.
(b) Pineoblastomas usually show poor enhancement.
(c) Germinomas are 10 times more common in males than females.
(d) Pineal germinomas are associated with Parinaud’s syndrome.
(e) Germinomas are hypodense on unenhanced CT.
Answers:
(a) Correct
(b) Not correct
(c) Correct
(d) Correct
(e) Not correct
Explanation:
Pineoblastomas show avid enhancement on post contrast images.
The isodense to hyperdense on CT.
They are similar to medulloblastoma as the both are part of neuroectodermal tumour group.
- Regarding differentiation between epidermoids and dermoids of the brain:
(a) Epidermoids more closely resemble cerebrospinal fluid on MRI.
(b) Both are formed due to enclosure of ectodermal elements when the neural tube closes.
(c) Epidermoids are more common.
(d) Epidermoids may become malignant.
(e) Fat-fluid level on imaging is highly suggestive of dermoids
Answers:
(a) Correct
(b) Correct
(c) Correct
(d) Not correct
(e) Correct
Explanation:
Dermoids and epidermoids are benign lesions and slow-growing and never become malignant.
- Concerning cerebellopontine angle masses:
(a) Meningiomas are the second commonest cerebellopontine angle mass.
(b) Meningiomas commonly cause expansion of the internal auditory canal.
(c) Meningiomas are typically brighter on T2 weighted MRI than T1.
(d) Epidermoids have the same signal as cerebrospinal fluid on MRI.
(e) Acoustic neuromas usually enhance poorly on post-contrast scans.
Answers:
(a) Correct
(b) Not correct
(c) Not correct
(d) Correct
(e) Not correct
Explanation:
Meningiomas do not cause expansion of internal auditory canal.
They are usually less bright on T2-weighted MRI.
Acoustic neuromas usually enhance avidly on postcontrast images.
- Concerning the differences between cortical contusions and diffuse axonal injury (DAI):
(a) Patients with cortical contusions are much less likely to have had loss of consciousness.
(b) Patients with cortical contusions usually have a better prognosis.
(c) Cortical contusions are more commonly haemorrhagic than DAI.
(d) CT is the best modality to diagnose acute DAI.
(e) Most patients with DAI suffer immediate loss of consciousness
Answers:
(a) Correct
(b) Correct
(c) Correct
(d) Not correct
(e) Correct
Explanation:
Diffuse axonal injury are seen much better on MRI than CT.
On MRI diffusion weighted images and susceptibility weighted images are most
- Concerning differences between primary CNS lymphoma and toxoplasmosis:
(a) Subependymal extension across the corpus callosum is more likely to occur in toxoplasmosis.
(b) High signal on T2 weighted MRI favours lymphoma.
(c) Toxoplasmosis is more frequently multiple.
(d) Ring enhancement following contrast administration favours lymphoma.
(e) The lesions are usually smaller in lymphoma.
Answers:
(a) Not correct
(b) Not correct
(c) Correct
(d) Not correct
(e) Not correct
Explanation:
CNS lymphoma shows subependymal extension across the corpus callosum. CNS lymphoma and toxoplasmosis
lesions can be smaller as well as large and should not be differentiated on basis of size.
Toxoplasmosis shows high signal on T2-weighted MRI and shows ring enhancement on post contrast images.
- Which of the following statements are correct about cerebellar medulloblastoma:
(a) Is more common in females.
(b) Is the commonest paediatric brain tumour.
(c) 75% of patents are less than 15 years of age.
(d) Calcification occurs in 40-50%.
(e) Is associated with basal cell carcinomas
Answers:
(a) Not correct
(b) Not correct
(c) Correct
(d) Not correct
(e) Correct
Explanation:
Medulloblastoma is the second commonest paediatric tumour, second only to astrocytoma however it is the
commonest paediatric posterior fossa tumour.
It occurs more commonly in males.
Calcifications are seen in up to 20% of patients. Cystic changes or necrosis are seen in up to 50%. They are usually
hyperdense on CT. On MRI, they are usually hypointense to grey matter on T1 weighted images and variable
appearance on T2-weighted images. Oedema is almost always seen.
- Concerning the differentiation between optic nerve glioma and optic nerve sheath meningioma:
(a) A widened optic canal is seen more commonly in optic nerve glioma.
(b) Optic nerve sheath meningioma affects an older age group.
(c) Optic nerve glioma typically shows the ‘tram-track’ sign on enhancement.
(d) Calcification is more commonly seen with optic nerve glioma.
(e) Optic nerve glioma may cause orbital hyperostosis.
Answers:
(a) Correct
(b) Correct
(c) Not correct
(d) Not correct
(e) Not correct
Explanation:
Optic nerve sheath meningioma affects older age usually middle aged woman.
Calcification can be seen with optic nerve meningioma but is the rarely seen with optic nerve glioma.
Optic nerve sheath meningioma typically shows the tram track sign on enhancement.
Optic nerve sheath meningioma causes orbital hyperostosis.
- Concerning intracranial lymphoma:
(a) It is usually a Hodgkin’s lymphoma.
(b) Secondary lymphoma more commonly involves the leptomeninges than the brain parenchyma.
(c) It is usually hypodense on unenhanced CT.
(d) It is normally high signal on T2 weighted images.
(e) Toxoplasmosis may mimic lymphoma in the brain
Answers:
(a) Not correct
(b) Correct
(c) Not correct
(d) Not correct
(e) Correct
Explanation:
CNS lymphoma are usually B-cell non-Hodgkin’s lymphoma. They are usually hyperdense on unenhanced CT.
There show intermediate to low signal on T2-weighted MR images.
- Concerning posterior fossa tumours in children:
(a) 80% of medulloblastomas arise from the vermis.
(b) Juvenile pilocytic astrocytomas are the second commonest posterior fossa tumour.
(c) Juvenile pilocytic astrocytomas usually calcify.
(d) Brainstem gliomas mostly affect the midbrain.
(e) Ependymoma seeds to the CSF in 30% of cases
Answers:
(a) Correct
(b) Correct
(c) Not correct
(d) Not correct
(e) Correct
Explanation:
Juvenile pilocytic astrocytomas are at the second commonest posterior fossa tumours after medulloblastoma. Only
20% of these calcify.
Brainstem gliomas mostly affect the pons.
- Concerning intraorbital pathology:
(a) The lacrimal gland is the most frequently involved orbital structure in idiopathic inflammatory pseudotumour.
(b) Idiopathic inflammatory pseudotumour is unilateral in 40-50% of cases in adults.
(c) Optic nerve glioma is the commonest tumour arising from the optic nerve sheath complex.
(d) Use of steroids differentiates idiopathic inflammatory pseudotumour from lymphoma.
(e) Thyroid eye disease is the most common disorder affecting the orbit.
Answers:
(a) Correct
(b) Not correct
(c) Correct
(d) Not correct
(e) Correct
Explanation:
Pseudotumour is unilateral in 80% of the cases in adults.
Use steroids in differentiating pseudotumour from lymphoma is not useful.