Cerebral cortex Flashcards

1
Q

Describe the grey and white matter in the brain

A

Grey outside, white inside

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2
Q

Describe the types of cerebral white matter

A

Association fibres: connect areas within the same hemisphere
Commissural fibres: connect left hemisphere to right hemisphere
Projection fibres: connect cortex with lower brain structures (e.g. thalamus), brain stem and spinal cord

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3
Q

Describe the cortical layers of the grey matter

A

1-3 - cortico-cortical connections
4 - thalamus
5+6 - subcortical, brainstem, spinal cord
Neocortex is arranged in layers (lamina structure) and columns
More dense vertical connections – basis for topographical organization
Neurons with similar properties are connected in the same column

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4
Q

Describe the function of the occipital lobe

A

Visual cortex + Visual association area = vision

visual association cortex analyses different attributes of visual image in different places
form and colour analyzed along ventral pathway; spatial relationships and movement along dorsal pathway

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5
Q

Describe the parietal lobe

A

Primary somatosensory cortex + Sensory association area = Sensory information from skin, musculoskeletal system, viscera and taste buds

posterior parietal association cortex creates spatial map of body in surroundings, from multi-modality information

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6
Q

Describe the frontal lobe

A

judgement, foresight, personality, appreciation of self in relation to world

Frontal lobe + prefrontal association area = coordinates into from other association areas, controls some behaviours
Primary motor cortex + motor association area = Skeletal muscle movement
Gustatory cortex = taste

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7
Q

Describe the temporal lobe and what a lesion would affect/cause

A

language, object recognition, memory, emotion

Auditory cortex + Auditory association area = hearing
Olfactory cortex = smell

injury leads to agnosia, receptive aphasia

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8
Q

Describe the primary cortices of the grey matter

A
function predictable
organised topographically
left-right symmetry
Primary motor cortex
Primary somatic sensory cortex
Visual cortex
Auditory cortex 
Gustatory cortex 
Olfactory cortex
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9
Q

Describe the association cortices of the grey matter

A
function less predictable
not organised topographically
left-right symmetry weak or absent
Prefrontal association area
Motor association area 
Sensory association area 
Visual association area
Auditory association area
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10
Q

What are the functions of the primary and association cortices combined

A

frontal - coordinates information from other association areas, controls some behaviour

Motor - skeletal muscle movement

Somatic sensory - sensory info formskin musculoskeletal system, viscera, taste buds

Visual - vision

Auditory - hearing

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11
Q

What can a lesion of the visual association Cortex lead to

A

Lesions of the visual posterior association area (fusiform gyrus) can result in the inability to recognize familiar faces or learn new faces—a deficit called prosopagnosia (aka face blindness).

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12
Q

What can a lesion of the frontal cortex lead to

A

Lack of planning
Behaviour becomes disorganised
Attention span and concentration diminish
Self-control is hugely impaired

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13
Q

What can a lesion of the parietal cortex lead to

A

disorientation
inability to read maps or understand spatial relationships
apraxia
hemispatial neglect

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14
Q

Describe hemispheric specialisation

A

Left - language dominant
Right - largely spatial processing

Patients who had a callosotomy (split brain) - lateralised deficits in function
Right - drawing, music, spatial perception
Left - writing, ears, calculation

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15
Q

What is diffusion tensor imaging

A

Used to measure the effect of lesions in white matter, or brain areas have been disconnected

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16
Q

What is transcranial magnetic stimualtion

A

The magnetic field induces an electric current in the cortex, causing neurons to fire.

This can be used to test whether a specific brain area is responsible for a function, e.g. speech

17
Q

What is transcranial direct current stimulation

A

Changes the local excitability of neurons, increasing or decreasing the firing rate
(NB, does not directly induce neuronal firing)
Could be used to reduce motion sickness

18
Q

Describe the PET scan

A

Positron emission tomography
Locates where a particular molecule (e.g. dopamine) is absorbed in the brain
Followed by administration of 18F-FDOPA

19
Q

What is a MEG and EEG

A

Magnetoencephalography(MEG) -functional neuroimagingtechnique for mapping brain activity

Electroencephalography (EEG) -electrophysiological monitoring method to record electrical activity of the brain. EEG measures voltage fluctuations resulting from ionic current within the neurons of the brain

20
Q

Describe the measurements taken with MEG and EEG

A

Event-related potential / evoked-potentials
EEG and MEG are noisy signals.
Participants perform large numbers of trials so that an average can be used

21
Q

Describe the fMRI

A

Measures brain activity by detecting changes associated with blood blow
Relies on cerebral blood flow and neuronal activation being coupled

22
Q

What are the layers of the grey matter

A

Dorsal -> ventral

Layers 1-3 = cortico-cortical connections
Layer 4 = input from thalamus
Layer 5-6 = connections with subcortical, brain stem and spinal cord

23
Q

What is the effect of a visual association cortex lesion

A

lesions affect specific aspects of visual perception

24
Q

What is the effect of a temporal lobe lesion

A

injury leads to agnosia, receptive aphasia