CFE Flashcards
(162 cards)
1
Q
type 1 kinase inhibitor
A
gefitinib
2
Q
leucovorin MAO
A
provides alternative path to form folate cofactos and rescues patient from high dose MTX
3
Q
1st vasopressor in septic shock
A
NE
4
Q
only IV P2Y12
A
Cangrelor
5
Q
high/low MW and High/low protein binding prevents drugs from getting to baby
A
high, high
6
Q
Refeeding syndrome
A
decrease in PO4, K, increase glucose
7
Q
Metabolic Alkalosis on Ph and HCO3
A
inc. pH inc. HCO3
8
Q
metabolic alkalosis what is expected compensatory respiratory response
A
dec. respiratory rate
takes mins to hours
9
Q
Mesna MOA
A
protects against bladder toxicity obsered upon acrolein generation
10
Q
cisplatin ADE
A
renal toxicity
11
Q
MTX MOA
A
folic acid antagonist
12
Q
Indication for trastuzumab
A
HER2+
13
Q
dabrafenib and trametinib indication
A
BRAF V600E or K
14
Q
TX of grade 1 diarrhea due to immunotherapy
A
continue immunotherapy
non-steroid symptom control
15
Q
2 meds for PCI
A
antiplatelets
anticoagulant
16
Q
sedative agent that doesn’t induce deep sedation
A
precedex
17
Q
T/F small molecule TKI need to be taken with high fat meals
A
F
18
Q
microtubule agents 4
A
eribulin
paclitaxel
ixabepoline
vinorelbine
19
Q
Vincristine ADE
A
peripheral neuropathy
20
Q
Bulimia 1st line tx
A
CBT fluoxetine
21
Q
Hematopoiesis originate
A
bone marrow of pelvis and vertebrae
22
Q
indicaiton for panitumumab
A
KRAS/NRAS wild-type
23
Q
purine analog activated by hypoxanthing guanine phosphoibosyl transferase
A
thioguanine
24
Q
Are tamoxifen and taloxifene estrogenic in bone?
A
yes
25
purine antagonist; inhibit purine ring synthesis; inhibit nucleotide interconversion
6-mercaptopurine
| 6-thioguanine
26
Fulvestrant is?
Pure antagonist to estrogen
27
Suggamaddex indication
reversal of NMBA of steroidal agents
28
Daunorubicin ADe
cardiotoxicity
29
ESA in cancer only used for?
palliative care
30
Diffuse large B cell lymphoma is what type of cancer
non-Hodgkin's lymphoma
31
Dabigatran reversal agent
Idarucizumab
32
vasopressor that only works on alpha receptors
phenylephrine
33
Ramucirumab in combo with what?
FOLFIRI
34
inactivation of tumor supresor genes may
reduce levels of CDKI
35
ADE of succinylcholine in ARF and hyperkalemic
ventricular tachycardia
36
inhibits non-receptor tyrosine kinase
imatinib
37
Pembolizumab MOA
anti PD-1 antibody used for tx of non small cell lung cancer
38
Lasix 40mg PO = what dose po bumetanide
1mg
39
Abiraterone ADE
hypokalemia and fluid retention and prevented with glucocorticoid
40
What antibiotic can't be used in 2nd trimester
tetracyclines
41
goal SBP for ICH
<160
42
NSTEMI which anticoagulant prior to cath lab
enoxaparin 1mg/kg
43
Cisplatin and Carboplatin are toxic to?
kidneys
44
reversal for heparin
protamine
45
how to prevent CNS disease in AMI
prophylaxis is not used
46
extended window for tpa
3-4.5 hours
47
Pre-menopausal women what is the source of estrogen
ovaries
48
5FU ADE
hand foot
49
PIP activates a pathway that
inhibits BAX
50
CCB for vasospasm
nimodipine
51
Brentuximab BBW
progressive multifocal leukoencaphalopathy
52
Copanlisib and Idelalisib indication
follicular lymphoma
53
hypovolemic shock
| MAP, CVP, CO, SVR
dec MAP
dec. CVP
dec. CO
inc. SVR
54
Midostaurin receptor
FLT3
55
6-Thioguanine is
purine antagonist; inhibits purine ring synthesis
56
PKB AND BAD
pkb phosphoylates BAD inactivates it = pro-survival
57
tx for repeptitive behavior in ASD
antidepressant
| antipsychotics
58
CDK inhibitors
palbociclib
59
T/F GDM increases risk of DM in mothers post birth
T
60
only available depolarizing nmba
succinylcholine
61
everolimus MOA
mTOR
62
ADE of zolendronic acid and denosumab
Osteonecrosis of the jaw
63
```
which would expect bleeding to resolve the quickest?
cangrelor
clopidogrel
prasugrel
ticagrelor
```
cangrelor
64
how long to use tamoxifen in postmenopausal women
5-10 years
65
repairs DNA double strand breaks with least amount of mistakes
homologous recombination
66
PI-3 kinase inhibitors
idelaslisib
| copanilisib
67
T/F NMBA have no effect on consciousness
True
68
type 2 kinase inhibitor
imatinib
69
Atezolizumab MOA
anti PD-1 antibody used for tx of local or metastatic urothelial carcinoma
70
1st line chemo for ovarian cancer
carboplatin
| paclitaxel
71
block topoisomerase function
```
camptothecins
etoposide
daunorubicin
doxorubicin
mitoxantrone
```
72
Define thrombocytosis
increased platelets
73
which resembles the antracyclines in terms of structure and anticancer MOA
mitoxantrone
74
TX for high risk for TLS
hydration
allopuinol
rasburicase
75
T/F DM in pregnancy can lead to hypoglycemia in neonates immediately after birth
T
76
HD cytarabine ADE
conjunctivitis
77
OA ofipilimumab
anti-cytotoxic T-lymphocyte antigen 4 antibody CTLA-4
78
inhibit Adenosine Deaminase
pentostatin
79
Mesna MOA
prevents toxicity caused by cyclophosphamide
80
succinylcholine inc/dec serum K
increase
81
in pt w/ augmented renal clearance what changes need to be made
reduction of dosing interval
82
does vincristine require activation
no
83
enzyme inhibitor
tyrosine kinase inhibitors
bortezomib
antibodies
84
Keshan's Disease
deficiency in Se
85
electrolytes to watch in starvation
K, mg, phosphorus
86
Enzalutamide moa
pure receptor antagonist used to treat prostate cancer
87
tumor supressor genes when inactivated
cancer results
88
NMBA for pt w/ dec renal and hepatic function
atracurium
89
Aprepitant MOA
NK-1 antagonist
90
DOC of BB in pregnancy
labetalol
91
Warm/Wet Hf 1st line drug
IV loop diuretics
92
5-FU MOA
directly inhibits thymidylate syntahse
93
Drug that isn't an antibody that inhibits CDK
- Herceptin
- Imatinib,
- Palbociclib,
- trametinib
Palbociclib
94
Gilteritinib receptor
FLT3
95
pegaspargase SE
hypersensitivity rxn
pancreatitis
VTE
96
React w/ DNA
```
alkylating agents
mitomycin
cisplatin
procarbazine
dacarbazine
bleomycin
```
97
inhibit function of microtubules
paclitaxel
vinca alkaloids
colchicine
98
Doxetaxel ADE
fluid retention
99
BAX: pro death or survival
pro-death
100
poison control hot line
18002221222
101
Vemurafenib MOA
directly inhibits oncogenically activated form of RAF
102
BB overdose tx
glucagon
103
WBC nadir occurs
7-14 days after chemo
104
Percutaneous meds have inc/dec absorption in infants
increased
105
Brimonidine MOA
alpha-2 agonist
106
sedative withno risk for kypotension
ketamine
107
oncogenes when activated
cancer results
108
lack of what electrolyte can lead to heart problems
Se
109
Dexrazoxane MOA
reduces anthracycline cardiotoxicity by chelating iron
110
Doxorubicin toxicity
cardiotixicity
111
TX for high emetogenic chemo
NK-1 antagonist
serotonin antagonist
dexamethasone
112
JNK and BCL-2
JNK phosphorylates BCL-2 inactivating it = pro-death
113
precedex inc/dec BP and HR
decrease
114
Med that inhibits ribonucleic reductase
hydroxyurea
115
Antibody acts on tyrosine kinase in EbB or eGF family
Herceptin
116
is ER/PR+ favorable?
yes
117
MEK inhibitors
trametinib
118
BCL-2 pro death or survival
pro-survival
119
BB eye drop cause what ADE
Bradycardia
120
inhibit ribonucleotide reductase
hydroxyurea
121
replaces bases on a single strand of dna after damaged site is processed by an endonuclease
base excision repair
122
inhibit TMP synthesis
5FU
123
Iron deficiency anemia has inc/dec MCV
decreased
124
which drugs are limited by myelosuppression
mercaptopurine
cytarabine
gemcitabine
125
seficinecy in dihydropyrimidine dehydrogenase suffer from SE from
5FU
126
inhibit DNA synthesis
gemcitabine
cytarabine
fludarabine
127
counseling for ESA
risk for vte
| rotate injection sites
128
BAD inactiavates
BCL-2 = pro-death
129
cardiogenic shock
| MAP, CVP, CO, SVR
Dec. MAP
Inc CVP
Dec. CO
Inc. SVr
130
dose of vit K to reverse warfarin in intracranial hemorrhage
10mg IV
131
Enasidenib receptor
IDH2
132
drugs w/ low potential to cause myelosuppresion at anti-cancer doses
cisplatin
bleomycin
streptomycin
133
max dose of tpa
90mg
134
EGFR antibodies
```
herceptin
pertuzumab
panitiumumab
kadcyla--ado-transtuzumab
erbitux
```
135
what is labeled hypertriglyceridemia for TPN
>400
136
1st line for wet and warm HF
IV loop diuretic
137
ASD sleep disturbance tx
Melatonin
138
bleomycin se
pulmonary fibrosis
139
warfarin ok in pregnancy?
no
140
antibody that binds to VEGF
bevacizumab
141
RAF kinase inhibitors
Vemurafenib
142
Abciximab MOA
glycoprotein 3a/2b
143
Warfarin ok in breastfeeding?
yes
144
inhibit protein synthesis
L-asparaginase deaminase
145
indication for ESA
Hbg <10
on palliative tx
myelosuppressive chemo for 2 more months
146
topotecan MOA
topoisomerase inhibitor
147
T/F doxo requires echo before initiation
true
148
Bevacizumab toxicity
HTN
149
type 3 kinase inhibitor
trametinib
150
SH2 binds to
phosphorylated tyrosine
151
counseling for panitumumab
use moisturizing creams and avoid OTC acne products to treat rash
152
Anion Gap formula
Na - (HCO3 + Cl)
153
cytochrome C and BAX?
is displaced from mitochondria by BAX
154
Leuprolide indication
receptor agonist used to treat prostate cancer
155
chemo prodrugs
irinotecan
156
Leucovorin used to limit what drug toxicities
MTX
157
does vinorelbine require activation
no
158
inhibitors of PARP
kills cells that are defective in homologous recombination
159
ANC calculation
(% neutrophil + % bands ) x WBC
160
inhibit RNA synthesis
dactinomycin
161
Ketamine effects BP T/F
F
162
NMBA longest acting steroidal agent
pancuronium
