Ch 10: Arteriosclerosis Flashcards Preview

Pathology Unit 4 > Ch 10: Arteriosclerosis > Flashcards

Flashcards in Ch 10: Arteriosclerosis Deck (11)
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1

How can you differentiate arteriolosclerosis and atherosclerosis easily?

Arteriolosclerosis = arterioles narrowing

Atherosclerosis = intimal plaque obstructing flow

2

hypertension, diabetes, hypercholesterolemia, and smoking are what kinds of risk factors for what?

Modifiable risk factors of atherosclerosis

3

Age, gender, and genetics are what kinds of risk factors for what? Give me how each is risky?

Nonmodifiable risk factors of atherosclerosis

Age = # and severity of lesion increase with age

Gender = increased risk in males and postmenopausal females; estrogen is protective

Genetics = family hx is highly predictive of risk

4

Types of arteries involved in atherosclerosis versus arteriolosclerosis?

Atherosclerosis = medium/large (abdominal aorta, coronary a, popliteal a, internal carotid a)

Arteriolosclerosis = small arterioles narrowing

5

What are foam cells?

When do fatty streaks arise?

damaged endothelium of bvs allows lipid leakage into intima, macrophages consume the oxidized lipids (foam cells)

Flat yellow lesions of intima containing foam cells = fatty streak arise in early life (present in teens)

6

4 main complications of atherosclerosis to worry about?

  1. Stenosis of medium sized vessels = impaired blood flow >> ischemia (Peripheral vascular disease, angina, ischemic bowel disease)
  2. Plaque rupture w/thrombosis results in MI (coronary a) and stroke (MCA)
  3. Plaque rupture w/emobolization
  4. Weakening of vessel wall results in aneurysm

7

What are the two types of arteriolosclerosis?

hyaline and hyperplastic types

8

What type of arteriolosclerosis is a consequence of long standing benign HTN or diabetes?

Hyaline

9

What type of arteriolosclerosis is a consequence of malignant HTN?

Hyperplastic

10

  • proteins leaking into vessel wall produces vascular thickening
  • classically produces glomerular scarring that slowly progesses to chronic renal failure
  • end organ ischemia due to reduced vessel caliber
  • Pathology??

Hylaine arteriosclerosis

11

  • thickening of vessel wall smooth muscle (onion skin appearance)
  • end organ ischemia
  • may lead to fibrinoid necrosis of bv with hemorrhage
  • classically causes acute renal failure, flea bitten appearance

Hyperplastic arteriolosclerosis