Ch 10 Epithelial pathology

Question 1

Benign proliferation thought to be viral induced, cauliflower appearing (fingerlike projections)

Answer 1

Squamous Papilloma

Question 2

Virus induced (HPV), frequent in children, common on skin and infrequent in oral cavity. Cutaneous horn form extreme accumulation of keratin

Answer 2

Verruca Vulgaris

Question 3

HPV, considered sexually transmitted. Koilocytes

Answer 3

Condyloma Acuminatum

- teenagers and young adults

Question 4

Hyperplastic condition of epithelium with characteristic accumulation of lipid laden histiocytes beneath the epithelium

Answer 4

Verruciform Xanthoma

- common in whites 40 to 70 females

Question 5

Viral induced localized proliferation of squamous cells, multiple flat or rounded papules which are usually clustered with normal color (not white)

Answer 5

Focal Epithelial hyperplasia aka Heck’s Disease

- Childhood condition

Question 6

Skin condition in elderly from chronic sun exposure with hereditary tendency
Brown plaque that appears to be “stuck on” skin

Answer 6

Seborrheic Keratosis

- Histo: horn & pseudo-horn cysts & melanin pigmentation in basal cell layer.

Question 7

Laser-Trelat sign is

Answer 7

numerous Seborrheic Keratosis with pruritus (itching) associated with internal malignancy

Question 8

Dermatosis papulosa nigra

Answer 8

type of SK occurs in 30% blacks with AD pattern.

Question 9

Ephelis (Freckle)

Answer 9

Genetic skin discoloration produced by excess of melanin deposition in the epidermis; blond and red hair. Sunscreen prevents new & darkening

Question 10

Age or liver spots. Don’t change in color intensity after exposure to UV light

Answer 10

Actinic Lentigo

Question 11

Mask of pregnancy

Answer 11

melasma - symmetric hyperpigmentation of sun exposed skin of face and neck

Question 12

Flat brown discoloration caused by focal increase in melanin deposition (maybe increased malanocytes). Not related to sun.

Answer 12

Oral Melanotic Macule

Question 13

Peutz-Jaehger’s Syndrome

Answer 13

associated with circum-oral and intra-oral pigmentation + intestinal polyps

Question 14

Benign acquired pigmentation.

Dendritic macrophages dispersed throughout epithelium

Answer 14

Oral melanoacanthoma

• Alarming growth rate
• Blacks only
• mostly females
• 30 to 40age
• Buccal Mucosa

Question 15

Acquired Melanocytic Nevus types

Answer 15

common mole

• Junctional nevus
• Compound nevus
• Intramucosal

Question 16

Leukoplakia high risk areas for malignancy

Answer 16

Floor of mouth
Ventral tongue
Soft palate

Question 17

Proliferative verrucous leukoplakia

Answer 17

SCCa usually within 8 years of PVL diagnosis

Question 18

Chronic, progressive, scarring, high risk precaancerous condition

• mucosal rigidity & pain
• trismus
• tongue immobile

Answer 18

Oral submucous fibrosis

- High malignant transformation rate

Question 19

Sun damaged lip cant tell where vermillion ends and skin begins

Answer 19

Actinic cheilitis

• chronic sun exposure and immunocompromised high risk
• Males

Question 20

Iron deficiency, greater risk for SCCa of esophagus, oropharynx and posterior mouth

Answer 20

Plummer-Vinson Syndrome

Question 21

Epstein Bar V is associated with which cancers

Answer 21

nasopharyngeal carcinoma

burkitt’s lymphoma