Ch. 12 GABA

Question 1

Inhibit GAT-1 or GABA transaminase= inhibit reuptake= more GABA in synapse

Answer 1

Tiagabine, Vigabatrin

Question 2

Blocks GABA reuptake

Answer 2

Tiagabine

Question 3

Blocks conversion of GABA to Succinic semialdehylde

Answer 3

Vigabatrin

Question 4

GABA Receptor modulators- agonists to GABA= Increase Frequency of receptor opening= Inc. GABA

Answer 4

Benzodiazepine

Question 5

Short acting Benzo:

Answer 5

Clorazepate, Midazolam, Triazolam, Zlopidem

Question 6

Intermediate acting Benzo:

Answer 6

Alprazolam, Estazolam, Lorazepam, Temazepam

Question 7

Long Acting Benzo:

Answer 7

Chlordiazepoxide, Clonazepam, Diazepam, Flurazepam, Quazepam

Question 8

Benzo for tonic Sz:

Answer 8

Diazepam, Loraz, Midaz

Question 9

Benzo for Status epilepticus

Answer 9

Midaz, Loraz

Question 10

Benzo for Abscent sz

Answer 10

Clonaz

Question 11

Benzo for amnesia

Answer 11

Midaz, Loraz

Question 12

Benzo for anxiety

Answer 12

Alpraz, clonaz, diaz

Question 13

Benzo for Alcohol Withdrawal

Answer 13

Chlordiazepoxide, Diaz

Question 14

Benzo for Insomnia

Answer 14

zolpidem

Question 15

metabolism of Benzo

Answer 15

Hepatic CYP 450

Question 16

Consideration of Benzo

Answer 16

Cross BBB, Respiratory depression

Question 17

Reverse Benzo

Answer 17

Flumazenil

Question 18

GABA Receptor modulators- Increase Duration that Cl- receptors are open

Answer 18

Barbiturates

Question 19

Barb for anestheia

Answer 19

Thiopental

Question 20

Barb for insomnia

Answer 20

Pentobarbital, Thiopental, secobarbital, amobarbital

Question 21

Barb for Status epilepticus

Answer 21

Pentobarbital, amobarbital

Question 22

Barb for Increase Incracranial Pressure

Answer 22

Thiopental

Question 23

Considerations of Barbs

Answer 23

Lipid soluble= enter brain, CYP 450 inducers (phenytoin, rifampicin)= reduces barbs, CYP450 inhibitors (ketoconazole, EES, cimetidine, SSRI)= Enhance effect

Question 24

Long Acting Barb

Answer 24

Phenobarbital- Refr. Epilepsy (good for kids)

Question 25

GABA Receptor modulators- Modulate ligand-gated ion channels

Answer 25

Etomidate, Propofol

Question 26

GABA Receptor Agonist- Activate metabotropic GABA receptor

Answer 26

Baclofen (spacticity)- withdrawal can precipitate acute hyeprsaspticity, rhabdo, pruritis, delerium, fever)

Question 27

NMDA Receptor Antagonist affecting Glutamate neurotransmission

Answer 27

Riluzole, Memantine, Amantadine, Lamotrigine, Felbamate

Question 28

For ALS

Answer 28

Riluzole

Question 29

For Alzhemiers

Answer 29

Memantine

Question 30

For Parkinsons

Answer 30

Amantadine

Question 31

For Bipolar I, Clonic Sz, with adverse= steven johnson

Answer 31

Lamotrigine

Question 32

For Refractory Epilepsy with adverse= aplastic anemia, hepatic failure

Answer 32

Felbamate