Pharm 30 Endocrine Pancreas/Glucose Homeostasis Part I

Question 1

alpha-glucosidase inhibitors (3)

Answer 1

acarbose
migitol
voglibose

Question 2

Prandial Bolus Insulins (4)

Answer 2

"LAGeR"
Insulin Lispro
Insulin aspart
Insulin glulisine
Regular Insulin

Question 3

Basal “ long acting “ insulins (3)

Answer 3

NPH insulin
insulin glargine
Insulin detemir

Question 4

First generation sulfonylureas (4)

Answer 4

TACT
tolbulamide
acetohexamide
chlorpropamide 
tolazamide

Question 5

Second generation sulfonylureas (5)

Answer 5

G's
Glimepiride
Glipizide
Glibenclamide
Gliclazide
Gliquidone

Question 6

Meglitinides (2)

Answer 6

Nateglinide

Repaglinide

Question 7

The biguanide (insulin sensitizer

Answer 7

Metformin

Question 8

Amylin Analogue

Answer 8

Pramlintide

Question 9

GLP-1 analoges

Answer 9

“El” GLP-1 analogues
Exenatide
Liraglutide

Question 10

DPP-4 inhibitors

Answer 10

Sit-Sax (instead of the sitaur)
Sitagliptin
Saxagliptin

Question 11

Thiazolidinediones (insulin sensitizers)

Answer 11

TZDs

Rosiglitazone

Question 12

Somatostatin analogue

Answer 12

Octreotide

Question 13

MOA: Bind avidly to intestinal brush border alpha glucosidase enzymes, slowing breakdown and absorption of dietary carbohydrates such as dextrin, and disaccharides

Answer 13

• alpha glucosidase inhibitors (acarbose, migitol, voglibose)

Question 14

Contraindications Include cirrhosis, DKA, digestive problems, IBD, and Bowel obstruction

Answer 14

alpha-glucosidases

Question 15

hypoglycemia is the sole CI for

Answer 15

Exogenous insulin

Question 16

DKA is the sole CI for

Answer 16

Sulfonylureas

Question 17

DKA + Type 1 diabetes are the CIs for

Answer 17

Meglitinides

Question 18

Contraindications are metabolic acidosis, Hepatic disease, Renal impairment, Respiratory distress, Alcohol abuse, Septicemia, Heart failure

Answer 18

Metformin

Question 19

What may result in a patient on Metformin that has received iodinated contrast media if acute alteration of renal function is an underlying issue ?

Answer 19

Lactic Acidosis

Question 20

Hypoglycemia + Gastroparesis CI for

Answer 20

Pramlintide

Question 21

ype 1 dm + DKA CI for

Answer 21

Incretins (GLP-1 analogues and DPP4 inhibitors

Question 22

Heart failure is the sole CI for

Answer 22

TZDs

Question 23

Patient with a pheochromocytoma cannot receive

Answer 23

exogenous glucagon

Question 24

Type 2 dm and polycystic ovarian syndrom are indicated for use of

Answer 24

Metformin

Question 25

Both Type 1 and type 2 diabetes mellitus can receive

Answer 25

Pramlinitide

Question 26

Hypoglycemia + Malignant hypertension(off-label) are both indications to use

Answer 26

Diazoxide

Question 27

Hypoglycemia + intestinal relaxant before radiography of GI indicated with

Answer 27

Exogenous glucagon

Question 28

Hypoglycemia, Rash, diarrhea, nausea, and dizziness are ADRs of

Answer 28

Meglitinides

Question 29

Nausea is the only ADR of

Answer 29

Pramlintide

Question 30

Hypoglycemia nausea vomitting diarrhea nervousness , dizziness and HEADACHE are ADRs of

Answer 30

GLP-1 analogues

Question 31

Rash, nausea, vomitting, are ADRS of

Answer 31

Glucagon

Question 32

Abdominal pain, diarrhea, flatulence, elvated serum AMINOTRANSFERASE levels, elevated plasma TGs are ADRs of

Answer 32

Exogenous Insulin

Question 33

Diarrhea, flatulence , nausea, vomiting , COBALAMIN DEF. and LACTIC ACIDOSIS are ADRs of

Answer 33

Metformin

Question 34

ADRs of Exog. Insulin

Answer 34

lipodystrophy , injection site rxn, hypoglycemia

Question 35

unique ADRs for DPP4 inhibitors (2)

Answer 35

mild increase in serum creatinin level and nasopharyngitis

Question 36

ADRs of TZD or Diazoxide ? fluid retention, DKA, hypernatremia

Answer 36

Diazoxide

Question 37

ADRs of TZD or Diazoxide ? cholestatic hepatitis hepatoxicity, diabetic macular edema

Answer 37

TZD

Question 38

ADRs of TZD or Diazoxide ? angina hypotension, tachyarrhytmia, hirsutism

Answer 38

DIazoxide

Question 39

ADRs of TZD or Diazoxide ? | hyperglycemia, dyspepsia, dizzines, glucosuria

Answer 39

Diazoxide

Question 40

ADRs of TZD or Diazoxide ? Edema , weight gain, increased HDL/LDL, decreased TG and FFA

Answer 40

TZD