Ch. 13 Hematopoietic Disorders and Classification of Anemia

Question 1

Bone marrow samples can be HYPERcellular or HYPOcellular of one cell type or all cell types. Define hyper and hypocellular

Answer 1

increased cellularity

decreased cellularity

Question 2

Define aplastic

Answer 2

when all blood cell types are decreased or absent int the bone marrow

Question 3

What are the 4 inflammatory conditions that may be evident when examining bone marrow?

Answer 3

1. Fibrinous
2. Chronic
3. Chronic granulomatous
4. Chronic pyogranulomatous

Question 4

What is fibrous inflammation?

Answer 4

involved the infiltration of the bone marrow within FIBRIN exudate without the presence of inalmmatory cells

Question 5

What is chronic inflammation?

Answer 5

a hyperplastic condition characterized by increased PLASMA cells, mature LYMPHOCYTES, and MAST cells

Question 6

What is chronic granulomatous inflammation?

Answer 6

characterized by increased MACROPHAGES

Question 7

What is chronic pyogranulomatous inflammation?

Answer 7

characterized by increased macrophages with the presence of neutrophils

Question 8

What are the 2 classifications of neoplastic disorders of hematopoiesis?

Answer 8

Lymphoproliferative
OR
Myeloproliferative

Question 9

What is the common term used to describe neoplastic blood in bone marrow?

Answer 9

Leukemia

Question 10

What is the function of RBCs?

Answer 10

to transport hemoglobin (oxygen)

Question 11

According to bone marrow response, anemia is classified as either ______ or _______

Answer 11

regenerative
or
non-regenerative

Question 12

Typically, the bone marrow responds to anemia by releasing immature RBCs to combat it. By looking at a blood smear and counting young RBCs, anemia can be classified as regenerative or non-regenerative. True or False?

Answer 12

True

Question 13

What animal rarely releases reticulocytes? What testing therefore usually needs to be done to classify anemia?

Answer 13

Horses

Bone marrow evaluation

Question 14

Reticulocytes are absent in patients with non-regenerative anemia. True or False?

Answer 14

True

Question 15

Iron deficiency, Ehrlichiosis, drug toxicity, histoplasmosis, hypothyroidism, and renal insufficiency are common causes for __________ anemia

Answer 15

NON-regenerative

Question 16

RBC indices can be used to help classify anemia as _____, _____, or ______

Answer 16

Macrocytic, microcytic, or normocytic

Question 17

What is normocytic anemia associated with?

Answer 17

variety of acute and chronic disorders

Question 18

What is macrocytic anemia associated with?

Answer 18

usually REGENERATIVE anemia

Question 19

What is microcytic anemia associated with?

Answer 19

almost always caused by IRON deficiency (usually 2’ to chronic blood loss)

Question 20

Hemolytic anemia is caused by what?

Is it usually regen or non-regen?

Answer 20

destruction of RBCs within the blood

usually REGENERATIVE

Question 21

RBC parasites, leptospira, FELV, blood transfusion incompatibility, toxins, etc are common causes of _____ anemia

Answer 21

Hemolytic

Question 22

What is hemorrhagic anemia caused by?

Answer 22

acute or chronic blood loss

Question 23

trauma, parasites, neoplasia, cystitis, GI ulceration, and coagulopathy are common causes of ______ anemia

Answer 23

hemorrhagic

Question 24

Iron deficiency anemia is caused by?

Answer 24

iron deficient diet

chronic blood loss

Question 25

Reduced rates of or defective erythropoiesis can result in normocytic anemia. True or False?

Answer 25

True

Question 26

CKD, hypothyroidism, hypoadrenocorticism, bracken fern poisoning, iron/copper deficiency, parvo, and lead toxicity result in reduced/defective erythropoiesis. True or False?

Answer 26

True