ch 14 Bone Pathology Flashcards
RL of several mm to several cm diameter
-Majority in edentulous portions of posterior mn in post-menopausal females
rocal osteoporotic marrow defect
- no expansion noted
- variant of normal, no txt needed
if diastemas start developing, what could you suspect? Also dentures and RPDs start getting tighter
Paget’s Disease
elevated alkaline phosphatase in a SMA 12 test indicates
Paget’s disease, (sometimes also seen in pregnancy from placenta)
bone undergoing resorption rimmed by osteoclasts in Howship’s lacunae
-and osteoblastic activity occurs around osteoid seams
Paget’s disease
what other ‘lesions’ are commonly or successively seen with paget’s disease?
- osteosarcoma
- central giant cell granuloma, nonaggressive and agressive lesions(female, anterior mandible)
appearance of fibrous dysplasia
- it is ALWAYS ill defined
- peau d’orange
- finger print, ground glass
onion skinning (periosteal reaction)
osteosarcoma
-and sunburst spiculation
codman’s triangle
osteosarcoma
-Tumor growing on surface of bone can elevate the periosteum and induce a periosteal reaction in the form of an open triangle
where are chondrosarcoma’s most often found?
predilection for trunk bones,
-in the jaw, occur in the maxillary anterior alveolus, orbit, nose, condyle or skull base
Radiolucent destruction with evenly distributed punctate or ring like calcifications
chondrosarcoma
Mild expansion with cortical thinning and endosteal scalloping
chondrosarcoma
what are the three grades of chondrosarcoma?
-Grade 1 – lobular architecture, rarely metastasize
• Grade 2 – myxoid stroma and mitotic figures, 10% met rate
• Grade 3 – markedly cellular, spindleform, abundant mitosis, 71% met rate
What is the txt for chondrosarcoma?
- Wide local or radical surgical excision is mainstay of therapy – may not be possible in skull base lesions
- Radioresistant and chemotherapy ineffective
