Ch 19 - Infections Flashcards Preview

Microbiology > Ch 19 - Infections > Flashcards

Flashcards in Ch 19 - Infections Deck (15):
1

Streptokinase

Enzyme virulence factor

Source: streptococci, staphylococci

Action: dissolve fibrin clot (produced by wbc); allow bacteria to travel through bloodstream -- further spread of infection; prevent isolation of infection

Used therapeutically as a clot-dissolving medication for heart attacks and pulmonary embolisms

2

Hyaluronidase

Enzyme virulence factor

Source: streptococci, staphylococci

Action: digest hyaluronic acid (bind epithelial cells together); allows tissue penetration - pathogens spread to deeper tissue

3

Coagulase

Enzyme virulence factor

Source: staphylococcus aureus

Action: induces fibrin blood clot; protection against white blood cells and phagocytosis

4

Leukocidin

Toxin virulence factor

Cytotoxic

Source: staphylococci, streptococci, pneumococci

Action: form pores and lyse wbc; destroy phagocytes -- limited phagocytosis of pathogen

5

Hemolysins

Toxin virulence factor

Cytotoxin

Source: clostridia, staphylococci, streptococci

Action: lyse red blood cells -- provide pathogen with source of iron for growth (needed for metabolism)

6

Anthrax toxin

Exotoxin

Organism: bacillus anthracis

Gene location: plasmid

Disease: anthrax


7

Botulism toxin

Exotoxin

Source - clostridium botulinum

Gene location: prophage

Disease: botulism

8

Enterotoxin A

Exotoxin

Source: staphylococcus aureus

Gene location: prophage

Disease: food poisoning

9

Pertussis toxin

Exotoxin

Source: bordatella pertussis

Gene location: chromosomal

Disease: pertussis/whooping cough

10

Coagulase-negative staphylococci

Nosocomial infection - blood infections

11

Staphylococcus aureus

Nosocomial infection - urinary, blood, lung, surgical site infections

12

Enterococcus species

Nosocomial infections - urinary tract, blood, surgical site infections

13

Candida species

Nosocomial infections - UTIs

14

Escherichia coli

Nosocomial infections - urinary and surgical site infections

15

Pseudomonas aeruginosa

Nosocomial infections - urinary, blood, surgical site infections