Ch. 20

Question 1

What are 2 tests to determine activity of antimicrobials?

Answer 1

1. Kirby Bauer/ disk diffusion 2. E-test/MIC

Question 2

Antifungal drugs

Answer 2

1. Echincandins 2. Flucytocine 3. Griseofuvin 4. Tolnftate

Question 3

Anti-helminthitic drugs

Answer 3

1.Niclosamide 2.Praziquantel 3.Mebendazole 4. albendazole 5.Ivermectin

Question 4

5 actions of ant-microbial drugs

Answer 4

1. Inhibiting cell wall synthesis 2. Injury to plasma membrane 3. Inhibition of nucleic acid replication and transcription 4.Interfere with translation 5. Interfere with enzymatic activity

Question 5

Anti-protozoan drugs

Answer 5

1. Chloroquine 2. Artemisinin 3.Metronidazole

Question 6

Anti-viral drugs

Answer 6

1.Indnavir 2. Zanamivir 3. Amatadine 4. Alpha-IFN

Question 7

Inhibitors of cell wall synthesis

Answer 7

1. Bacitran 2. Vancomycin-the last line of defense antibiotic

Question 8

Inhibitors of protein synthesis

Answer 8

1. Chloramphenicol 2. Streptomycin 3. Neomycin 4. gentamycin 5. Tetracyclines

Question 9

Inhibitors of nucleic acid synthesis

Answer 9

1. Rifamycin 2. Quinolones 3. Fluoroquinolones

Question 10

Competitive Inhibitors of synthesis of essential Metabolites

Answer 10

Sulfonamides- inhibit folic acid synthesis

Question 11

What is the genera of bacteria that produce the most antibiotics?

Answer 11

Streptomyces (ex. Neomycin)

Question 12

What is one thing penicillins have in common?

Answer 12

Beta lactam ring

Question 13

Penicillinase

Answer 13

Enzyme produced by bacteria that inactivates penicillin(breaks Beta lactam ring)

Question 14

Synergism

Answer 14

when the effects of 2 drugs together is greater than the effect of either alone

Question 15

Antagonism

Answer 15

the effect of 2 drugs together is less than the effect of either alone