Ch. 22 Abnormal Cell Growth Flashcards Preview

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Flashcards in Ch. 22 Abnormal Cell Growth Deck (28):
1

•Proteins from these genes control cell growth & differentiation
•Examples: epidermal growth factor, Ras, Raf, Src, cyclins

Protooncogenes

2

•Proteins from these genes control cell growth & differentiation
•Examples: epidermal growth factor, Ras, Raf, Src, cyclins

Protooncogenes

3

Protooncogenes ,If mutated are called

oncogenes

4

Controls unregulated progression through cell cycle

Tumor Suppressor Genes

5

Most common mutation =

TP53 (codes for p53 protein)

6

•Controls genes for growth regulation
•Facilitates DNA repair
•Signals apoptosis, if necessary

p53 protein

7

Therapy would require death or removal of all tumor cells as a cure

Clonal Evolution Model

8

Stem Cell Theory

9

Cancer development is a stepwise process

Stage 1-4

(progression, Metastasis)

10

(Cancer development)

Initial genetic insult

Initiation

11

(Cancer development)

Multiple mutations lead to an increased number of mutated cells

Promotion

12

(Cancer development)

Tumor development

Progression

13

(Cancer development)

Tumor cell invasion

Metastasis

14

Self-sufficient growth signals
Ignores anti-growth signals
Evades apoptosis
Limitless replication potential
Angiogenesis (new blood supply using VEGF)
Reprogramming energy metabolism
Evading immune destruction
Metastasis

Hallmarks of Cancer

15

The more ........ the mutation, the higher the........... of cancer is to the individual

rare, risk

16

Protooncogenes ,If mutated are called

oncogenes

17

Controls unregulated progression through cell cycle

Tumor Suppressor Genes

18

Most common mutation =

TP53 (codes for p53 protein)

19

•Controls genes for growth regulation
•Facilitates DNA repair
•Signals apoptosis, if necessary

p53 protein

20

Therapy would require death or removal of all tumor cells as a cure

Clonal Evolution Model

21

less then 1% of all cells in a tumor have stem cell activity (limitless replication potential)

Stem Cell Theory

22

Cancer development is a stepwise process

Stage 1-4

(progression, Metastasis)

23

(Cancer development)

Initial genetic insult

Initiation

24

(Cancer development)

Multiple mutations lead to an increased number of mutated cells

Promotion

25

(Cancer development)

Tumor development

Progression

26

(Cancer development)

Tumor cell invasion

Metastasis

27

Self-sufficient growth signals
Ignores anti-growth signals
Evades apoptosis
Limitless replication potential
Angiogenesis (new blood supply using VEGF)
Reprogramming energy metabolism
Evading immune destruction
Metastasis

Hallmarks of Cancer

28

The more ........ the mutation, the higher the........... of cancer is to the individual

rare, risk