Ch. 22 Abnormal Cell Growth Flashcards Preview

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Flashcards in Ch. 22 Abnormal Cell Growth Deck (28)
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1
Q
  • Proteins from these genes control cell growth & differentiation
  • Examples: epidermal growth factor, Ras, Raf, Src, cyclins
A

Protooncogenes

2
Q
  • Proteins from these genes control cell growth & differentiation
  • Examples: epidermal growth factor, Ras, Raf, Src, cyclins
A

Protooncogenes

3
Q

Protooncogenes ,If mutated are called

A

oncogenes

4
Q

Controls unregulated progression through cell cycle

A

Tumor Suppressor Genes

5
Q

Most common mutation =

A

TP53 (codes for p53 protein)

6
Q
  • Controls genes for growth regulation
  • Facilitates DNA repair
  • Signals apoptosis, if necessary
A

p53 protein

7
Q

Therapy would require death or removal of all tumor cells as a cure

A

Clonal Evolution Model

8
Q

A

Stem Cell Theory

9
Q

Cancer development is a stepwise process

A

Stage 1-4

progression, Metastasis

10
Q

(Cancer development)

Initial genetic insult

A

Initiation

11
Q

(Cancer development)

Multiple mutations lead to an increased number of mutated cells

A

Promotion

12
Q

(Cancer development)

Tumor development

A

Progression

13
Q

(Cancer development)

Tumor cell invasion

A

Metastasis

14
Q
Self-sufficient growth signals
Ignores anti-growth signals
Evades apoptosis
Limitless replication potential
Angiogenesis (new blood supply using VEGF)
Reprogramming energy metabolism
Evading immune destruction
Metastasis
A

Hallmarks of Cancer

15
Q

The more …….. the mutation, the higher the……….. of cancer is to the individual

A

rare, risk

16
Q

Protooncogenes ,If mutated are called

A

oncogenes

17
Q

Controls unregulated progression through cell cycle

A

Tumor Suppressor Genes

18
Q

Most common mutation =

A

TP53 (codes for p53 protein)

19
Q
  • Controls genes for growth regulation
  • Facilitates DNA repair
  • Signals apoptosis, if necessary
A

p53 protein

20
Q

Therapy would require death or removal of all tumor cells as a cure

A

Clonal Evolution Model

21
Q

less then 1% of all cells in a tumor have stem cell activity (limitless replication potential)

A

Stem Cell Theory

22
Q

Cancer development is a stepwise process

A

Stage 1-4

progression, Metastasis

23
Q

(Cancer development)

Initial genetic insult

A

Initiation

24
Q

(Cancer development)

Multiple mutations lead to an increased number of mutated cells

A

Promotion

25
Q

(Cancer development)

Tumor development

A

Progression

26
Q

(Cancer development)

Tumor cell invasion

A

Metastasis

27
Q
Self-sufficient growth signals
Ignores anti-growth signals
Evades apoptosis
Limitless replication potential
Angiogenesis (new blood supply using VEGF)
Reprogramming energy metabolism
Evading immune destruction
Metastasis
A

Hallmarks of Cancer

28
Q

The more …….. the mutation, the higher the……….. of cancer is to the individual

A

rare, risk