Ch. 23 Cell Death Flashcards Preview

cell phys final > Ch. 23 Cell Death > Flashcards

Flashcards in Ch. 23 Cell Death Deck (16):
1

Pathological >Injury or disease > Groups of cells are induced to die > Passive; damages neighboring cells > Inflammation

Necrosis
(Days)

2

Physiological > Programmed cell death > Active; no damage to neighboring cells >
No inflammation

White Blood Cells**

Apoptosis
(hours)

3

Due to injury or disease

Cells increase in size & lyse

inflammatory

Necrosis

4

moves from inner to outer leaflet

Apoptosis

Phosphatidylserine

Apoptosis

5

Mitochondria release

Apoptosis

cytochrome c

Apoptosis

6

........................... in nucleus condenses/ shuts down

Apoptosis

Chromatin

Apoptosis

7

Specialized white blood cell preventing inflammation

Apoptosis

Macrophage

Apoptosis

8

Cytochrome c exits mitochondria

Apoptosis Initiation – Internal Signal

9

Cytochrome c triggers

apoptosome

10

Death receptors can initiate apoptosis (tumor necrosis factor receptor) > Ligands contain a ........................ > cytochrome c

‘death domain’

External Signal

11

Major function is apoptosis

Caspases

12

prodeath signals > prosurvival

apoptotic cells

13

Members of Bcl-2 family (the BAD proteins)

Prosurvival (antiapoptotic)

14

•Bak & Bax proteins
•Signal permeation of the mitochondria

Prodeath (apoptotic)

15

type 1 diabetes

Autoimmune diseases

16

•Altered neuronal apoptosis in patients with schizophrenia
•Localized apoptosis in many forms of dementia, including Alzheimer’s disease

Neurodegenerative diseases