Ch. 25 - Antiinflammatory Drugs Flashcards Preview

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Flashcards in Ch. 25 - Antiinflammatory Drugs Deck (64)
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1

Inflammation

1.) Response to tissue injury & infection
2.) Vascular reaction
3.) Protective mechanism

2

Infection:

caused by microorganisms --> inflammation

3

5 Characteristics of Inflammation:

1.) Erythema
2.) Edema
3.) Heat
4.) Pain
5.) Loss of function

4

Prostaglandins:

1.) Released when cellular injury takes place
2.) Injection of prostaglandins into body --> inflammatory process

5

Cyclooxygenase (COX):

COX1 = protects stomach lining & regulates platelets

COX2 = triggers inflammation & pain

6

Antiinflammatory Agents:

-Nonsteriodal agents
-Steroidal agents

7

Nonsteriodal Antiinflammatory Drugs (NSAIDS):

Aspirin

-Aspirin like drugs --> inhibit COX2 enzyme

8

Nonsteriodal Antiinflammatory Drugs (NSAIDS): cont...

Salicylates & Nonsalicylates
1st generation NSAIDs
2nd generation NSAIDs (COX2 inhibitors)

9

Salicylates (ASA):

Strong prostaglandin inhibitor
---> reduces inflammatory process

Inhibits prostaglandin synthesis
---> COX1 & COX2 enzymes

10

Acetylsalicylic Acid (ASA) (1):

Antiplatelet drug:
-Decrease platelet aggregation
-Decrease blood clotting

11

Acetylsalicylic Acid (ASA) (2):

Low doses ---> analgesic, antipyretic effect

Higher doses ---> anti-inflammatory effect

12

Acetylsalicylic Acid (ASA) (3):

Most common adverse effects:
1.) Gastric irritation
2.) Occult Bleeding

13

Hypersensitivity to ASA

1.) Tinnitus
2.) Vertigo
3.) Bronchospasm

14

Tx of Headache (HA) / Fever:

1.) ASA
2.) Acetaminophen
3.) Ibuprofen

15

Tx of Inflammation / Swelling, Pain, Stiff Joints

NSAIDs = cost more than ASA

Contraindicted:
-allergic to ASA (asa is Aspirin)

16

Over the Counter (OTC) NSAIDs:

1.) Ibuprofen (Motrin, Advil)
2.) Naproxen (Aleve)

17

Rx Drugs that Contain NSAIDs :

*1st Generation ------------------*2ndGeneration
-meloxican (Mobic) ---------- celecoxib (Celebrex)
-naproxen (Naprosyn)
-nabumentone (Relafen)

18

Nursing Process (ASA):

Observe for signs of bleeding:
1.) Dark Stools
2.) Bleeding Gums
3.) Petechiae
4.) Ecchymosis

Bleeding from an IV site

19

Client Teaching (ASA) (1):

1.) DO NOT take with:
-Alcohol
-Anticoagulant Drugs

2.) Inform Dentist

3.) d/c 3-7 days before surgery

20

Client Teaching (ASA) (2):

Do not give to children for virus/flu symptoms
- Reye Syndrome

21

Client Teaching (ASA) (3):

4.) Take with:
-Food/meals
-Fluids

5.) Enteric coated

22

Other NSAIDs (1):

indomethacin (Indocin):
1.) Po/ rectal
2.) Arthritis
3.) Strong prostaglandin inhibitor
4.) Highly protein bound
5.) Very irritating to stomach

23

Other NSAIDs (2):

ketorolac (Toradol):
1.) IM / IV / po
2.) Greater analgesic properties
3.) Short-term pain relief
4.) Opiate level analgesia

24

SE /Adverse Reactions (1st Generation NSAIDs):

1.) Fewer SE than ASA
2.) GI irrigation (take with food)
3.) Sodium & water retention
4.) Alcohol ---> increase gastric irritation

25

Selective COX2 Inhibitors:

2nd Generation
**Drug of choice for severe arthritis

-Does not inhibit COX1
Ex: Celecoxib (Celebrex)

26

Corticosteroids:

Steroid

Tx: inflammatory disorders
-Local
-Systemic

27

Corticosteroids (1)

1.) Produced in adrenal cortex

2.) Anti-inflammatory properties (Glucocorticoid)

3.) Salt-retaining properties (Mineralcorticoid)

28

Corticosteroids (2):

High doses / over long periods --->
-suppress hypothalamic pituitary adrenal hormone production

29

Corticosteroids (3):

Glucocorticoid properties:
- alter CHO, protein, & lipid metabolism

30

Corticosteroids (4):

Mineralcorticoid properties:
-Enhance reabsorption of sodium
-increase excretion of potassium & hydrogen ions ---> effects fluid / electrolyte