Ch. 3 Anatomy, Physiology, and Pathology Flashcards

(45 cards)

1
Q

Cytokine important in B and T cell development

A

IL-7

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2
Q

positive selection of T cells occurs?

A

thymic cortex

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3
Q

negative selection of T cells occurs?

A

begins in thymic cortex, finishes in medulla

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4
Q

What are Hassall corpuscles?

A

small bodies of granular cells surrounded by concentric layers of epithelial cells in the medulla

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5
Q

Where are resting B cells found?

A

primary follicle in the lymph node

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6
Q

Where is the germinal center of B cell proliferation located?

A

secondary follicle

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7
Q

Where are T cells located in the LN?

A

parafollicular cortex

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8
Q

How does the spleen receive lymphocytes and antigen?

A

via splenic artery (no afferent lymph supply)

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9
Q

Where is MALT (mucosa associated lymphoid tissue) located?

A

lamina propria and submucosa

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10
Q

Nasal airway resistance is regulated by?

A

swelling of the inferior turbinate at the level of the nasal valve

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11
Q

Which sinuses are present at birth?

A

maxillary and ethmoid sinuses

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12
Q

What sinuses drain into the middle meatus (into hiatus semilunaris)?

A

frontal, maxillary, and anterior ethmoids

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13
Q

What sinuses drain into the sphenoethmoidal recess?

A

posterior ethmoids, sphenoid sinus

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14
Q

What opens into the inferior meatus?

A

nasolacrimal duct

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15
Q

Where is the sphenoethmoidal recess located?

A

above the superior turbinate

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16
Q

Anterior ethmoid air cells above the middle turbinate

A

Agger nasi cells

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17
Q

Extramural ethmoid air cells found on the floor of the orbit

A

Haller cells

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18
Q

Sphenoethmoid air cell, found in close proximity to the internal carotid artery and optic nerve

A

Onodi cells

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19
Q

Air cell in the middle turbinate

A

Concha bullosa

20
Q

What innervates the tympanic membrane?

A

auriculotemporal nerve (perceives pain)

21
Q

3 most common causes of eustachian tube blockage in children?

A

infection, allergy, enlarged adenoids

22
Q

Corkscrew shaped twists of condensed mucus

A

Curschmann’s spirals

23
Q

Clusters of surface epithelial cells

A

Creola bodies

24
Q

Eosinophil cell and granule membrane lysophospholipase

A

Charcot Leyden crystals

25
The epithelium, reticular basement membrane and bronchial smooth muscle remodeling differ in asthma compared to COPD in what ways?
Asthma: denuded epithelium, thickened BM, sm muscle hypertrophy in large airways rather than small airways
26
Macrophages in the skin express what CD marker?
CD68
27
Why epitope is expressed by dermal T cells that plays a role in skin homing?
CLA-1 (cutaneous lymphocyte antigen)
28
Where are connective tissue MCtc mast cells located?
skin, conjunctiva (eye), heart, and intestinal submucosa
29
Where are mucosal mast cells MCt located?
alveolar wall, respiratory epithelium and small intestinal mucosa
30
Which mast cell type contains the CD88 receptor for C5a?
MCtc (connective tissue mast cell)
31
What chemokines are important in skin homing?
CCR4 / CCL17 and CCR10 / CCL27
32
Function of filaggrin?
matrix protein promoting aggregation and disulfide bonding of keratin filaments
33
mutations in filaggrin have been associated with which diseases
atopic dermatitis and ichthyosis vulgaris
34
in immunobullous disease what two biopsies are helpful for diagnosis
shave biopsy of intact bulla or vesicle; and biopsy of perilesional tissue for DIF
35
Formation of erosion due to sheering pressure applied on normal appearing skin
Nikolsky's sign
36
Autoantibody for pemphigus vulgaris
IgG to desmoglein 1,3
37
Autoantibody for bulls pemphigoid
IgG to BP230, BP180
38
Autoantibody for dermatitis herpetiformis
IgA to epidermal transglutaminase
39
Defensins are produced in response to what cytokines?
IL-1 and TNF
40
Lymphoid follicles in GALT?
Peyer's patches
41
Specialized epithelial cells with microvilli that help in antigen sampling in the gut?
M cells
42
which mediators are implicated in EoE
IL-5 and eotaxin
43
Natural history of Allergic proctocolitis or eosinophilic proctolcolitis
presents in infancy with bloody stools, associated with breast fed, resolves that by age 1 year no association with atopy or IgE food allergy.
44
Histopathology findings in celiac disease
blunted villi, crypt hyperplasia, and lymphocytic infiltrate
45
Diagnosis of celiac disease
screen with IgA to TTG, and intestinal biopsy when patient still eating gluten