Ch. 3 Anatomy, Physiology, and Pathology Flashcards Preview

ACAAI Review 3rd Edition > Ch. 3 Anatomy, Physiology, and Pathology > Flashcards

Flashcards in Ch. 3 Anatomy, Physiology, and Pathology Deck (45):
1

Cytokine important in B and T cell development

IL-7

2

positive selection of T cells occurs?

thymic cortex

3

negative selection of T cells occurs?

begins in thymic cortex, finishes in medulla

4

What are Hassall corpuscles?

small bodies of granular cells surrounded by concentric layers of epithelial cells in the medulla

5

Where are resting B cells found?

primary follicle in the lymph node

6

Where is the germinal center of B cell proliferation located?

secondary follicle

7

Where are T cells located in the LN?

parafollicular cortex

8

How does the spleen receive lymphocytes and antigen?

via splenic artery (no afferent lymph supply)

9

Where is MALT (mucosa associated lymphoid tissue) located?

lamina propria and submucosa

10

Nasal airway resistance is regulated by?

swelling of the inferior turbinate at the level of the nasal valve

11

Which sinuses are present at birth?

maxillary and ethmoid sinuses

12

What sinuses drain into the middle meatus (into hiatus semilunaris)?

frontal, maxillary, and anterior ethmoids

13

What sinuses drain into the sphenoethmoidal recess?

posterior ethmoids, sphenoid sinus

14

What opens into the inferior meatus?

nasolacrimal duct

15

Where is the sphenoethmoidal recess located?

above the superior turbinate

16

Anterior ethmoid air cells above the middle turbinate

Agger nasi cells

17

Extramural ethmoid air cells found on the floor of the orbit

Haller cells

18

Sphenoethmoid air cell, found in close proximity to the internal carotid artery and optic nerve

Onodi cells

19

Air cell in the middle turbinate

Concha bullosa

20

What innervates the tympanic membrane?

auriculotemporal nerve (perceives pain)

21

3 most common causes of eustachian tube blockage in children?

infection, allergy, enlarged adenoids

22

Corkscrew shaped twists of condensed mucus

Curschmann's spirals

23

Clusters of surface epithelial cells

Creola bodies

24

Eosinophil cell and granule membrane lysophospholipase

Charcot Leyden crystals

25

The epithelium, reticular basement membrane and bronchial smooth muscle remodeling differ in asthma compared to COPD in what ways?

Asthma: denuded epithelium, thickened BM, sm muscle hypertrophy in large airways rather than small airways

26

Macrophages in the skin express what CD marker?

CD68

27

Why epitope is expressed by dermal T cells that plays a role in skin homing?

CLA-1 (cutaneous lymphocyte antigen)

28

Where are connective tissue MCtc mast cells located?

skin, conjunctiva (eye), heart, and intestinal submucosa

29

Where are mucosal mast cells MCt located?

alveolar wall, respiratory epithelium and small intestinal mucosa

30

Which mast cell type contains the CD88 receptor for C5a?

MCtc (connective tissue mast cell)

31

What chemokines are important in skin homing?

CCR4 / CCL17 and CCR10 / CCL27

32

Function of filaggrin?

matrix protein promoting aggregation and disulfide bonding of keratin filaments

33

mutations in filaggrin have been associated with which diseases

atopic dermatitis and ichthyosis vulgaris

34

in immunobullous disease what two biopsies are helpful for diagnosis

shave biopsy of intact bulla or vesicle; and biopsy of perilesional tissue for DIF

35

Formation of erosion due to sheering pressure applied on normal appearing skin

Nikolsky's sign

36

Autoantibody for pemphigus vulgaris

IgG to desmoglein 1,3

37

Autoantibody for bulls pemphigoid

IgG to BP230, BP180

38

Autoantibody for dermatitis herpetiformis

IgA to epidermal transglutaminase

39

Defensins are produced in response to what cytokines?

IL-1 and TNF

40

Lymphoid follicles in GALT?

Peyer's patches

41

Specialized epithelial cells with microvilli that help in antigen sampling in the gut?

M cells

42

which mediators are implicated in EoE

IL-5 and eotaxin

43

Natural history of Allergic proctocolitis or eosinophilic proctolcolitis

presents in infancy with bloody stools, associated with breast fed, resolves that by age 1 year no association with atopy or IgE food allergy.

44

Histopathology findings in celiac disease

blunted villi, crypt hyperplasia, and lymphocytic infiltrate

45

Diagnosis of celiac disease

screen with IgA to TTG, and intestinal biopsy when patient still eating gluten