Ch. 453 - Physiologic Anemia of Infancy Flashcards Preview

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Flashcards in Ch. 453 - Physiologic Anemia of Infancy Deck (21)
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1
Q

T/F Physiologic anemia of infancy is related to downregulation of EPO production from increase in blood O2 content and delivery with a shift in type of Hgb synthesized (fetal to adult type)

A

T

2
Q

Physiologic anemia is reached between ___ and ___ weeks of age when hgb concentration is about ___g/dL

A

8 and 12, 11

3
Q

In healthy term infants, the nadir of physiologic anemia rarely falls below ___

A

10g/dL

4
Q

Is there a need for iron supplementation for hgb synthesis in physiologic anemia of infancy

A

No; supply of stored reticuloen- dothelial iron, derived from previously degraded RBCs, remains suf- cient for this renewed Hb synthesis, even in the absence of dietary iron intake, until approximately 20 wk of age

5
Q

T/F Physiologic anemia of infancy reflects excess tissue O2 requirements relative to O2 delivery

A

F; excess oxygen delivery relative to tissue oxygen requirements

6
Q

T/F There is no hematologic problem, and no therapy is required unless physiologic anemia of infancy is exacerbated by other ongoing processes.

A

T

7
Q

Mild hemolytic disease of newborn may be seen with the persistence of maternally-derived anti-RBC Abs in the infant’s circulation, leading to low-grade hemolytic anemia; Retic count in mild HDN is

A

Low

8
Q

Lower-than-expected hgb at the physiologic nadir of hgb in infants may be seen in what conditions

A

Mild HDN, intrauterine or neonatal RBC transfusions

9
Q

T/F Premature infants develop a physiologic anemia, known as physiologic anemia of prematurity where hgb decline is both more extreme and more rapid

A

T

10
Q

Nadir in physiologic anemia of prematurity is seen when

A

3-6 weeks of age

11
Q

Usual level of physiologic anemia of prematurity

A

7-9g/dL

12
Q

Life span of premature infant RBC

A

40-60 days

13
Q

T/F Plasma EPO levels in anemia of prematurity are lower than would be expected for the degree of anemia

A

T

14
Q

During fetal life, EPO synthesis is handled primarily by what organ

A

Liver

15
Q

T/F Oxygen sensor of the liver is relatively insensitive to hypoxia when compared to the oxygen sensor of the kidney

A

T

16
Q

The developmental switch from liver to kidney EPO production is not accelerated by early birth

A

T

17
Q

T/F Vitamin E deficiency plays a role in anemia of prematurity

A

F

18
Q

When transfusions are necessary for physiologic anemia of newborn, ___ is the amount recommended

A

10-15cc/kg

19
Q

T/F It is good practice to split units derived from a single donor so that sequential transfusions can be given as required and donor exposure can be minimized.

A

T

20
Q

In early preterm infants (weighing <1,250 g), the half-life of transfused RBCs is about ___

A

30 days

21
Q

T/F Delayed cord clamping or umbilical cord milking at birth results in fewer transfusions and a reduction in both intraventricular hemorrhage and necrotizing enterocolitis in preterm infants.

A

T