CH13: Takayasu Arteritis

Question 1

Takayasu first described this finding in patients with Takayasu Arteritis

Answer 1

wreath-like anastomosis

Question 2

What decade/age Takayasu is more commmon?

Answer 2

Third or fourth decade

Question 3

What antigen was studied in patients with Takayasu arteritis?

Answer 3

HLA-DP antigen

Question 4

Pathological finding in TA (acute phase)

Answer 4

lymphoplasmacytic inflammation affecting primarily the tunica media, causing the destruction of elastic lamellae

Question 5

Pathologic finding in TA (intermediate phase)

Answer 5

Partially necrotic media is revascularized by new branches of the vasa vasorum

Question 6

Pathologic finding in TA (sclerosing stage)

Answer 6

rigid, thick-walled tubes, with severe narrowing or occlusion by superimposed thromboses

Question 7

Classification of TA

Answer 7

I: only branches of aortic arch
IIa: aorta and ascending portion
IIb: descending aorta involved (abdominal aorta NOT involved)
III: descending aorta + abdominal aorta + renal arteries involved
IV: only the abdominal aorta and or renal arteries
V: generalized type

Question 8

Neurologic manifestations of TA are due to:

Answer 8

• severe hypertension
• carotid or brachiocephalic obstruction

Question 9

T/F subclavian steal phenomenon occurs in patients with TA?

Answer 9

Yes.

Question 10

Differential diagnosis for TA?

Answer 10

Arteriosclerosis
Buerger disease
Congenital vessel anomaliies
Coarctation of the aorta
Dissecting aneurysms
Collagen disease
Behcet disease