CH15: Stroke and Neurosarcoidosis

Question 1

Size of vessels affected by neurosarcoidosis

Answer 1

Small and medium-sized

Question 2

Non-CNS organ primarily affected by sarcoidosis?

Answer 2

Lung
Lymphatic system

Question 3

Most common neurologic manifestation of sarcoidosiis?

Answer 3

Cranial neuropathies

Question 4

T/F Stroke are exceedingly rare complications of neurosarcoidosis?

Answer 4

TRUE

Question 5

Fundamental pathologic abnormaliity in sarcoidosis?

Answer 5

Non-necrotizing granulomas, organized collections of macrophages and epitheloid cells encircles by lymphocytes

Question 6

Cardinal feature of immunologic events in patients with sarcoidosis?

Answer 6

Presence of CD4 T cells that interact with antigen-presenting cells to initiate granuloma formation

Question 7

Potential mechanisms of stroke in patients with neurosarcoidosis?

Answer 7

1. obliterative fibrosis
2. cytokine-induced alterations of procoagulant pathways
3. abnormalities in fibrinolysis

Question 8

Mechanism of intracranial hemorrhage in patients with neurosarcoidosis?

Answer 8

increase in vascular permeability as a potential mechanism of intracerebral hemorrhage in neurosarcoidosis

Question 9

Treatment options for neurosarcoidosis

Answer 9

Corticosteroids
Use of immmunomodulating cytotoxic drugs
MM, methotrexate, azathioprine, cyclophosphamide, chloroquine, cylosporine, chlorambucil and infliximab