Ch2 Liver Flashcards

(122 cards)

1
Q

Amebic hepatic abscess

A

an abscess that develops from a parasite that grows in the colon and invades the liver via the portal vein

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2
Q

anastomosis

A

the surgical connection between two structures

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3
Q

arteriovenous fistula

A

an abnormal passageway between an artery and a vein

following trauma to the liver, an abnormal passageway between an after & vein

may also be discovered following a liver biopsy, cholangiography, or hepatic surgery

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4
Q

autoimmune disorders

A

disorders in which the body’s immune system attacks and destroys health tissues and/or organs

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5
Q

autosomal dominant polycystic kidney disease

AKA?

A

an inherited disease that results in the development of renal, liver, and pancreatic cysts late in life
also referred to as ADULT POLYCYSTIC KIDNEY DISEASE

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6
Q

bare area

A

the region of the liver not covered by peritoneum

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7
Q

Beckwith-Wiedmann syndrome

A

a growth disorder syndrome synonymous with enlargement of several organs, including the skull, tongue, and liver

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8
Q

Budd-Chiari syndrome

A

a syndrome described as the occlusion of the hepatic veins with possible coexisting occlusion of the inferior vena cava

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9
Q

caput medusa

A

recognizable dilation of the superficial veins of the abdomen

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10
Q

cavernous hemangioma

A

the most common benign liver tumor
they can be found in men, but are more common in women
are asymptomatic

is within the rt lobe of the liver
will appear small, hyperechoic mass measuring less than 3cm, although some may be quite large and referred to as “giant hemangiomas”
occasionally, posterior enhancement may be seen

although hemangiomas are comprised of blood vessels, detectable flow may not be seen with color Doppler because the flow within the vessels tend to be exceedingly slow

they may also appear hypoechoic or complex, and therefore can be monographically indistinguishable from metazoic liver disease

there may also be multiple hemangiomas present, further complicating the sonographic diagnosis and consequently leading to other imagining or biopsy

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11
Q

cholangitis

A

inflammation of the bile ducts

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12
Q

cirrhosis

A

condition defined as hepatocyte death, fibrosis and necrosis of the liver, and the subsequent development of regenerating nodules

cirrhosis can also be caused by Wilson disease, primary biliary cirrhosis, hepatitis, cholangitis, and hemochromatosis

lab findings include: elevation of AST, LDH, ALT & Bilirubin

patients may also present with jaundice, fatigue, weight loss, diarrhea, initial hepatomegaly, and ascites

sonographic findings include an echogenic small right lobe, an enlarged caudate and left lobe, nodular surface irregularity, coarse echo texture ascites, and splenomegaly

NORMAL nodules typically measure less than 1 cm (micro nodular) \
Cirrhosis caused nodules measure between 1 - 5 cm (macro nodular)

Doppler findings in patients WITH cirrhosis: monophonic flow within the hepatic veins & hepatofugal flow within the portal veins

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13
Q

cystic fibrosis

A

genetic disorder linked with the development of scar tissue accumulation within the lungs, liver, pancreas, kidneys, and or intestines

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14
Q

diaphragmatic slip

A

a pseudo mass of the liver seen on sonography resulting from hypertrophied diaphragmatic muscle bundles

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15
Q

dystentery

A

infection of the bowel which leads to diarrhea that may contain mucus and/or blood

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16
Q

echinococcal cyst

AKA?

A

aka hydatid liver cyst
which is a liver cyst that develops from a tapeworm that lives in dog feces; also referred to as ECHINOCOCCAL CYST because it originates from the parasite ECHINOCOCCUS GRANULOSUS

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17
Q

Echinococcus granulosus

A

a parasite responsible for the development of hydatid liver cysts

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18
Q

Epstein-Barr virus

A

the virus responsible for the mononucleosis and other potential complications

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19
Q

fatty liver
AKA?
types?

A

a reversible disease characterized by deposits of fat within the hepatocytes
AKA: HEPATIC STEATOSIS
Types:
Nonalcoholic fatty liver disease - has been cited as the MOST common liver disorder in the western world & the MOST common cause of chronic liver disease
Alcoholic fatty liver disease - caused from heavy life long drinking
Causes of NONALCOHOLIC: starvation, obesity, chemotherapy, diabetes mellitus, hyperlipidemia, pregnancy, glycogen storage disease or VON GIERKE DISEASE (glycogen storage disease type 1), total parental hyperalimentation, severe hepatitis, cystic fibrosis, intestinal bypass surgery for obesity, and the use of some drugs such as corticosteroids

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20
Q

fibrosis

A

the formation of excessive fibrous tissue; the development of scar tissue within an organ

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21
Q

focal fatty infiltration

A

manifestation of fatty liver disease in which fat deposits are localized
it will appear as an area of increased echogenicity and can thus appear much like a solid, hyperechoic mass

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22
Q

focal fatty sparing

A

manifestation of fatty liver disease in which an area of the liver is spared from fatty infiltration
it is much more likely that the signs of sparing and infiltration are seen adjacent to the gallbladder, near the portal hepatic , and the left medial segment

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23
Q

focal nodular hyperplasia

A

a benign liver mass composed of combination of hepatocytes and fibrous tissue that typically contains a central scar
are asymptomatic

it is the SECOND most common benign liver tumor and MORE COMMONLY incidentally discovered in women

mass is composed of a combination of hepatocytes and fibrous tissue

most patients are asymptomatic, but if the mass impinges upon surrounding anatomy or hemorrhage occur, pain will most likely ensue

not caused by oral contraceptives, it can enlarge because of them (masses are estrogen dependent)

may appear isoechoic, echogenic, and hypoechoic

the central scar, when seen, will appear as a hypoechoic or hyperechoic, linear structure within the mass

hypervascularity within the scar can be identified by using color doppler

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24
Q

gastroesophageal junction

A

the junction between the stomach and the esophagus

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25
Glisson capsule
the thin fibrous casing of the liver
26
hematemesis
vomiting blood
27
hematoma
a localized collection of blood can appear solid or complex depending on their age
28
hemochromatosis
an inherited disease characterized by disproportionate absorption of dietary iron
29
hepatic candidiasis
a hepatic mass that results from the spread of fungus (primarily Candida albicans) in the blood to the liver affects those that are immunocompromised patient may have right RUQ pain, fever & hepatomegaly findings include multiple hyperechoic (central portion) masses with hypoechoic boarders these masses may be described as "target," "halo," or "bull's-eye" lesions and are typically 1 cm or smaller older lessons may calcify
30
hepatic encephalopathy
a condition in which a patient becomes confused or suffers from intermittent loss of consciousness secondary to the overexposure of the brain to toxic chemicals that the liver would normally remove from the body in a newborn, brain damage can occur with severe jaundice, as a result of bilirubin exposure, a condition referred to as kernicterus
31
hepatic steatosis
aka fatty liver | a reversible disease characterized bad deposits of fat within the hepatocytes
32
hepatitis | types?
inflammation of the liver Types: Acute - is said to resolve within 4 months Chronic - persists beyond 6 months A, B, C, D, E & G; the 2 MOST common are: hepatitis A & B Currently, hepatitis C is the leading indication for liver transplantation in the US
33
hepatocellular adenoma | AKA?
a RARE benign liver mass often associated with the use of oral contraceptives AKA HEPATIC ADENOMA or LIVER CELL ADENOMA pt is typically asymptomatic, but hemorrhage of the tumor leads to abdominal pain and because of the hemorrhage and a small propensity to become malignant (termed malignant degeneration), hepatic adenomas are often surgically removed and although a solid, hypoechoic echogenicity is common, they may be hyperechoic, isoechoic, or have mixed echogenicities *it is mostly hypoechoic*
34
hepatofugal | hepatopetal
hepatofugal - blood flow AWAY from the liver | hepatopetal - blood flow TOWARDS the liver
35
hepatoma
the malignant tumor associated with hepatocellular carcinoma
36
hepatomegaly
enlargement of the liver
37
hepatosplenomegaly
enlargement of the spleen and liver
38
hydatid liver cyst | AKA?
a liver cyst that develops from a tapeworm that lives in dog feces also referred to as an echinococcal cyst because it originates from the parasite Echinococcus granulosus may appear as an anechoic mass containing some debris (aka hydatid sand) may have the "water lily" sign, or "mother" cyst containing the "daughter" cysts the mass may also contain some elements of dense calcification
39
hyperlipidemia
abnormally high levels of fats within the blood (i.e. high cholesterol and high triglycerides)
40
hypovolemia
decreased blood volume
41
idiopathic
no recognizable cause; from an unknown origin
42
immunocompromised
a patient who has a weakened immune system
43
jaundice
the yellowish discoloration of the skin, mucous membranes, and sclerae; found with liver disease and/or biliary obstruction
44
kernicterus
brain damage from bilirubin exposure in a newborn with jaundice
45
Kupffer cells
specialized macrophages within the liver that engulf pathogens and damaged cells
46
leukocytosis
an elevated WBC count
47
lipoma
a benign fatty tumor
48
liver hilum
the area of the liver where the common bile duct exits the liver and portal vein and hepatic artery enter the liver; also referred to as the portal hepatis
49
low-resistance flow
a flow patter that characteristically has integrate flow throughout the cardiac cycle
50
malaise
feeling of uneasiness
51
malignant degeneration
the deterioration of a benign mass into malignancy
52
mass effect
the displacement or alteration of normal anatomy that is located adjacent to a tumor
53
monophasic
vascular flow yielding a single phase
54
necrosis
death of tissue
55
periportal cuffing
an increase in the echogenicity of the portal triads as seen in hepatitis and other conditions the sonographic manificstation of this phenomenon is referred to as the "starry sky" sign
56
porta hepatis
the area of the liver where the portal vein and hepatic artery enter an dot hepatic duct exit; also referred to as the liver hilum
57
portal hypertension
the elevation of blood pressure within the portal venous system with portal hypertension, the coronary vein will demonstrate abnormal flow toward the esophagus and will measure greater than 6mm
58
portal triads
an assembly of a small branch of portal vein, bile duct, and hepatic artery that surround each liver lobule
59
portal vein thrombosis
the development of clot within the portal vein is seen in conditions such as HCC, portal hypertension, pancreatitis, cholecystitis, pregnancy, oral contraceptive use, and surgery the development of collaterals within the portal vein region will occur; these small vessels try to shunt blood around the clot.
60
pseudocirrhosis
nodular appearance of the liver caused by multiple metastatic tumors
61
pseudomass
false mass
62
pyogenic liver abscess
a liver abscess that can result from the spread of infection from inflammatory conditions such as appendicitis, diverticulitis, cholecystitis, cholangitis, and endocarditis the bacteria enter the liver through the PV, HA, Biliary tree, or from an operative procedure clinical symptoms: fever, leukocytosis, possible abnormal liver function tests, right upper quadrant pain, and hepatomegaly it may appear as a complex cyst with thick walls, debris, separation, and/or gas. the air within the abscess may produce dirty shadowing or ring-down artifacts
63
quadrate lobe
the medial segment of the left lobe
64
recanalization
the reopening of canals or pathways
65
Riedel lobe
a tonguelike extension of the right hepatic lobe
66
sequela
an illness resulting from another disease, trauma, or injury
67
serpiginous
twisted or snakelike pattern
68
situs inversus
condition in which the organs of the abdomen and chest are on the opposite sides of the body (i.e. the liver is within the left upper quadrant instead of the right upper quadrant)
69
splenomegaly
enlargement of the spleen
70
starry sky sign
the sonographic sign associated with the appearance of perioportal cuffing in which there is an increased echogenicity of the walls of the portal triads
71
steatohepatitis
a type of fatty liver disease that causes inflammation of the liver is a precursor for chronic liver disease, leading to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) in some individuals
72
total parental hyperalimentation
procedure in which an individual receives vitamin and nutrients through a vein, often the subclavian vein
73
transjugular intrahepatic portosystemic shunt (TIPS)
the therapy for portal hypertension that involves the placement of stent between the portal veins and hepatic veins to reduce portal systemic pressure
74
triphasic
vascular flow yielding three phases
75
von Gierke disease
condition in which the body does not have the ability to break down glycogen; also referred to as glycogen storage disease type 1
76
von Hippel-Lindau disease
a inherited disease that includes the development of cysts within the liver, pancreas, and other organs
77
Wilson disease
a congenital disorder that causes the body to accumulate excess copper
78
associated abnormalities if you have a decrease of albumin:
chronic liver disease | cirrhosis
79
associated abnormalities if you have an increase of ALP (alkaline phosphatase):
``` cirrhosis extra hepatic biliary obstruction gallstones hepatitis metastatic liver disease pancreatic carcinoma ```
80
associated abnormalities if you have an increase of ALT (alanine aminotransferase)
biliary tract obstruction hepatitis hepatocellular disease obstructive jaundice
81
associated abnormalities if you have increase of AST (aspartate aminotransferase)
cirrhosis fatty liver hepatitis metastatic liver disease
82
associated abnormalities if you have increase gamma-Glutamyl transferase
diffuse liver disease | post hepatic obstruction
83
associated abnormalities if you have increase LDH (lactate dehydrogenase)
cirrhosis hepatitis obstructive jaundice
84
associated abnormalities if you have increase of Serum bilirubin
unconjugated (direct) bilirubin: acute hepatocellular disease conjugated (indirect) bilirubin: biliary tract obstruction total bilirubin: cirrhosis, hepatitis, and other liver cell diseases
85
associated abnormalities if you have PT (prothrombin)
prolonged PT: metastasis of the liver and hepatitis | shortened PT: extra hepatic duct obstruction
86
associated abnormalities if you have increase AFP (a-Fetoprotein)
``` hepatocellular carcinoma (hepatoma) hepatoblastoma ```
87
clinical findings of fatty liver disease:
``` asymptomatic alcohol abuse chemotherapy diabetes mellitus elevated liver function est (specifically AST & ALT) hyperlipidemia obesity pregnancy ```
88
sonographic findings of diffuse fatty liver disease:
diffusely echogenic liver increased attenuation of the sound beam wall of the hepatic vasculature and diaphragm will not be easily imaged
89
sonographic findings of focal fatty infiltration
hyperechoic area adjacent to the gallbladder, near the port hepatic, or part of a lobe may appear echogenic
90
sonographic findings of focal fatty sparing
hypoechoic area adjacent to the gallbladder, near the portal hepatic, or part of a lobe or an entire lobe may be spared can appear much like pericholecystic fluid when identified adjacent to the gallbladder.
91
Clinical findings of Hepatitis
``` chills dark urine elevated liver function sets (ALP, ALT, AST, LDH, total bilirubin, prothrombin (PT)) fatigue fever hepatosplenomegaly jaundice nausea vomiting ```
92
sonographic findings of hepatitis
normal liver enlarged hypoechoic liver periportal cuffing with "starry sky" gallbladder wall thickening
93
clinical findings of cirrhosis
``` ascites diarrhea abnormal liver function tests (specifically elevated ALP, ALT, AST, bilirubin, PT, partial prothrombin time (PTT), total protein, and decreased albumin) fatigue hepatomegaly (initial) jaundice splenomegaly weight loss ```
94
sonographic findings of cirrhosis
``` hepatosplenomegaly (initial) shrunken, echogenic right lobe of th eliver enlarged caudate and left lobes nodular surface irregularity coarse echotexture splenomegaly ascites monophonic flow within the hepatic veins hepatofugal flow within the portal veins ```
95
examples of portosystemic collaterals that may result from portal hypertension
``` coronary vein short gastric vein gastrorenal pathway splenorenal pathway umbilical vein anterior abdominal wall vein superior mesenteric vein ```
96
clinical findings of portal hypertension
``` abnormal liver function tests ascites diarrhea fatigue hepatomegaly (initially) hepatic encephalopathy caput medusa tremors gastrointestinal bleeding ```
97
Sonographic findings of portal hypertension
hepatomegaly (initially) shrunken right lobe of the liver enlarged caudate lobe of the liver nodular surface irregularity coarse echotexture splenomegaly ascites monophonic flow within the hepatic veins hepatofugal flow within the portal veins enlargement o the portal vein (diameter will exceed 13 mm in the anteroposterior dimension) enlargement of the superior mesenteric vein enlargement and reversed flow within the coronary vein enlarged hepatic arteries abdominal varicosities at the splenic hilum, renal hilum, and gastroesophageal junction patent paraumbilical vein (also called a reanalyzed paraumbilical vein)
98
clinical findings of portal vein thrombosis
``` abdominal pain elevated liver function tests hypovolemia leukocytosis low-grade fever nausea vomiting ```
99
sonographic findings of portal vein thrombosis
echogenic thrombus within the portal vein cavernous transformation of the portal veins will appear as wormlike or serpiginous vessels within the region of the portal vein
100
clinical findings of portal venous gas
recent bout of diverticulitis, appendicitis, inflammatory bowel disease, bowel obstruction, ulcers within the bowel, gastrointestinal cancer, and invasive procedures that involve stent placement (TIPS) or endoscopic analysis of the bowel
101
sonographic findings of portal venous gas
small, bright reflectors noted within the circulating blood inside the portal vein large air collections may produce ring-down artifact
102
clinical finding of budd-chiari syndrome
``` ascites elevated liver function test hepatomegaly splenomegaly upper abdominal pain ```
103
sonographic findings of Budd chiari syndrome
nonvisualization or reduced visualization of the hepatic veins thrombus within the hepatic veins enlarged caudate lobe lack of flow within the hepatic veins with color doppler narrowing of the IVC
104
diffuse infiltration
will cause the liver to appear diffusely echogenic, and it will be more difficult to penetrate the walls of the hepatic vasculature and diaphragm will not be easily imaged, secondary to the attenuation of the sound beam
105
hemopoiesis
the formation and development of blood cells
106
Portosystemic collaterals & vericosities
can consequently develop within the abdomen as a result of the body's attempt to repair itself by channeling blood away from the damaged liver
107
clinical findings of hepatic cysts
asymptomatic possible normal liver function tests ADPKD (autosomal dominant polycystic kidney disease) Hemorrhagic or large cysts may cause right upper quadrant pain
108
sonographic findings of hepatic cysts
anechoic mass or masses with posterior enhancement may have irregular shapes clusters of cysts may be noted
109
clinical findings of hydatid liver cyst
``` leukocytosis low-grade fever nausea obstructive jaundice RUQ tenderness possible recent travel abroad ```
110
sonographic finding of a hydatid liver cyst
anechoic mass containing some debris (hydatid sand) "water lily" sign appears as an endocyst floating within the pericyst "mother" cyst containing one or more smaller "daughter" cyst mass may contain some elements of dense calcification
111
clinical findings of an amebic hepatic abscess
``` hepatomegaly RUQ or General abdominal pain general malaise diarrhea (possibly bloody) fever leukocytosis elevated liver function tests mild anemia possible recent travel abroad ```
112
sonographic findings of amebic hepatic abscess
round hypoechoic or anechoic mass or masses may contain debris (with fluid-debris layering) acoustic enhancement
113
clinical findings of a pyogenic hepatic abscess
``` fever hepatomegaly leukocytosis possible abnormal liver function tests right upper quadrant pain ```
114
sonographic findings of a pyogenic hepatic abscess
complex cyst with thick walls mass may contain debris, separations, and/or gas the air within the abscess may produce dirty shadowing or ring-down artifact
115
clinical findings of hepatic candidiasis
immunocompromised patients including cancer patients, recent organ transplant patients, and patients w/ human immunodeficiency virus RUQ pain fever hepatomegaly
116
sonographic findings of hepatic candidiasis
multiple masses with hyperechoic center portions & hypoechoic boarders (may be described as "target," "halo," or "bull's-eye" lesions) these masses are typically 1 cm or smaller in size older lesions may calcify
117
hepatic lipoma
is rarely encountered; patients are asymptomatic, and its sonographic appearance is that of hyperechoic mass
118
Hepatic Hematoma
can be consequence of trauma or surgery pts will have pain and a decreased hematocrit can be located within the liver parenchyma, termed INTRAHEPATIC, or around the liver, which is termed SUBCAPSULAR (under Glisson capsule). they can appear solid or complex depending on their age initial hemorrhage appears echogenic with the development of clot, and over time as it resolves, it may appear more cystic or complex
119
Focal Hematoma
have been known to calcify
120
hepatocellular carcinoma
HCC is the MOST COMMON primary form of liver cancer (although it's not encountered as often as metastatic liver disease) Is found most often in men, and accompanied by cirrhosis, or chronic hepatitis the malignant mass associated w/ HCC is referred to as HEPATOMA other causes: hemochromatosis, von Gierke disease, and Wilson disease pts w/ HCC will have possible abnormal liver function tests, signs of cirrhosis, history of chronic hepatitis, unexplained weight loss, hepatomegaly, fever, abdominal swelling with ascites, and perhaps a palpable mass a tumor marker for HCC is serum alpha-fetoprotein (AFP) in the fetus, AFP is produced in lg amounts by the liver in an adult, low levels of AFP exist MOST patients w/ HCC will have an ELEVATED AFP - this occurs because AFP is produced in excess by the malignant hepatocytes that make up the tumor there may be an individual mass, or multiple masses, it may appear as a solitary, small, hypoechoic mass, or as heterogeneous masses scattered throughout the liver a hypoechoic halo MAY BE noted around the hepatoma as well, yielding the "target" or "bull's-eye" pattern - - the target lesion will yield a hypoechoic rim, with the center of the mass often isoechoic to normal liver tissue
121
Hepatic Metastasis
It is the MOST COMMON form of liver cancer; it is much MORE COMMON than primary liver cancer BECAUSE malignant cells from OTHER SITES enter the liver through the PV or Lymphatic channels. Primary cancers that metastasize to the liver include: gallbladder, colon, stomach, pancreas, breast, & lung (lung being the most common primary source). Patients w/ hepatic metastasis may present w/ weight loss, jaundice, RUQ pain, hepatomegaly, and ascites; HOWEVER, about half of patients there are no signs/symptoms INCLUDING normal liver function tests. Mastatic cancer -- from the gastrointestinal tract & pancreas tends to be calcified tumors Hyperechoic Masses -- tend to arise from the gastrointestinal tract as well, most commonly the colon, but they may also be from the kidney, pancreas, or biliary tree. Hypoechoic Masses -- may be from the breast, lung, or lymphoma Cystic Metastatic Masses -- within the liver have also been seen with ovarian cancers Metastatic disease -- in the liver can appear as an individual mass, several large masses, or diffuse involvement Target lesions -- are also common w/ metastasis and may be the expression of lung or colon metastasis within the liver, although they may be the manifestation of many forms of cancer Diffuse metastasis -- can produce an appearance of a nodular liver (PSEUDOCIRRHOSIS) Masses can appear: hyperechoic, hypoechoic, calcified, cystic, or heterogeneous masses mass or masses demonstrating a hypoechoic rim & central echogenic region diffusely heterogeneous liver possible ascites
122
Normal flow w/in the PV should be? Normal HV flow? Normal HA flow?
PV: Hepatopetal, continuous, monophonic, & have low velocity (between 20-40 cm/sec). HV: typically demonstrate a triphasic flow pattern (assessment should be obtained at the END of respiration) HA: should demonstrate a continuous, low-resistance wave form pattern, with a quick upstroke, and gradual deceleration with diastole (normal resistive index of the HA is between 0.5-0.8)