Ch20 Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

Question 0

What is the most common type of leukemia in older adults

Answer 0

CLL

Question 1

Disorders that are proliferations of morphologically and immunophenotypically mature B or T lymphocytes are known as:

Answer 1

Chronic lymphoproliferative disorders

Question 2

What is CLL characterized by?

Answer 2

Peripheral blood a BM lymphocytes

Question 3

Small lymphocytic lymphoma involves mainly:

Answer 3

Lymph nodes- and a lesser extent of BM and peripheral blood

Question 4

CLL cells show what type of morphology?

Answer 4

Increased prolymphocytes
Proliferating lymphocytes which are larger in size
Increased lymphoplasmacytoid cells

Question 5

What are the consequences of accumulating lymphocyte mass in CLL?

Answer 5

Neutropenia
Anemia
Thrombocytopenia
Lymphadenopathy and or splenomegaly

Question 6

What is the prolonged survival rate of patients with CLL?

Answer 6

5-10 years

Question 7

Patients with CLL have a significantly impaired immunologic activity that leads to:

Answer 7

Bacterial infections in respiratory tract, urinary tract, and skin
Autoimmune hemolytic anemia

Question 8

What percentage of normal T-cells circulate in lymphocyte peripheral blood smear?

Answer 8

61-89%

Question 9

When does the malignancy of B lymphocytes of CLL progress normally?

Answer 9

Final stages of B-cell development

Question 10

What is a common feature in CLL? (Common to many malignancies)

Answer 10

Monoclonality rather than polyclonality

Question 11

What percentage of lymphocytes are in the BM in CLL?

Answer 11

30%

Question 12

What type of anemia is seen in CLL?

Answer 12

Normochromic and normocytric

Question 13

What is the most common chromosomal abnormality in B-CLL?

Answer 13

Trisomy 12

Question 14

What treatment is commended for CLL patients with worsening conditions?

Answer 14

Chemotherapy

Sometimes radiation if lymphoid mass is localized

Question 15

How can CLL be differentiated from ALL?

Answer 15

Chromatin in CLL is heavy and clumped

Question 16

Reactive lymphocytes is most commonly caused by:

Answer 16

A viral infection, such as mononucleosis, viral hepatitis,

Question 17

The cells of CLL are morphologically identical to those of:

Answer 17

Small lymphocytic lymphoma

Question 18

Surface immunoglobulin is the most reliable surface marker for:

Answer 18

B lymphocytes

Question 19

Cells that demonstrate a positive exactions with the tartrate -resistant acid phosohatase (TRAP) stain are more likely:

Answer 19

Hairy cells of hairy-cell leukemia

Question 20

A mutated tumor suppressor gene found in a variety of human cancers, including CLL is:

Answer 20

p53

Question 21

In chronic lymphocytic leukemia:

Answer 21

The absolute lymphocyte count is usually equal to or exceeds 5000 x 10^9 cells/L

Question 22

The poorest prognosis for patients with CLL is associated with what features?

Answer 22

Anemia

Thrombocytopenia