Ch21 The Lymphomas

Question 0

What is the probable infectious agent of HL?

Answer 0

EBV

Question 1

What are the 2 major categories of malignant lymphoma?

Answer 1

Hodgkin disease

Lymphocytic lymphoma

Question 2

EBV nucleic acids can be demonstrated in the lesions of approx ____ of cases of HL

Answer 2

80%

Question 3

What is the cytology as hallmark of HL?

Answer 3

The presence of an unusual giant cell, the Reed-Sternberg cell

Question 4

Name characteristics of the Reed-Sternberg cell?

Answer 4

45um in diameter
Abundant eosinophil cytoplasm
Multinucleated or polylobated nucleus
Gigantic inclusion-like nucleus
Clearing of the chromatin

Question 5

What are the clinical features of HL?

Answer 5

Complaint of non-painful lymph node swelling

Question 6

The diagnosis of HL requires:

Answer 6

Tissue biopsy and microscopic evaluation

Question 7

How is staging evaluation of HL determined?

Answer 7

By the number of lymph nodes involved and which lymph nodes are involved

Question 8

What is the survival rate of stages I and II of HL?

Answer 8

80% exceed 10 years

Question 9

What is used to show nonrandom chromosome abnormalities in about 60% of non-HL?

Answer 9

Karyotyping

Question 10

What are the types of NHL?

Answer 10

B-cell and T-cell NHL

Question 11

What is the most common type of NHL?

Answer 11

B-cell 85-90%

Question 12

Give an example of a B-cell NHL

Answer 12

Burkitt lymphoma - uncool led proliferation

Question 13

Where is Burkitts lymphoma predominantly an endemic?

Answer 13

Africa

Question 14

Describe the cell morphology seen in Burkitts lymphoma

Answer 14

Lipid vacuoles in cytoplasm
Medium sized lymphocytes
High frequency of tumor cell incorporated EBV genomes
Facial bone involvement

Question 15

What treatment is used for diffused aggressive lymphoma?

Answer 15

Multiagent chemotherapy

Question 16

What infectious agent is most commonly associated with the pathogenesis of HL?

Answer 16

Epstein-Barr virus

Question 17

The cell characteristic of all types of classic HL is the:

Answer 17

Reed-Sternberg cell

Question 18

An a asymptomatic mediastinal mass affecting a young women is a common form of presentation for which type of HL?

Answer 18

Nodule-sclerosing

Question 19

Burkitts lymphoma is histologically characterized by:

Answer 19

Uniform nuclei
High mitotic rate
Starry sky pattern

Question 20

Lymphoblastic lymphomas are associated with:

Answer 20

High frequency of developing acute lymphoblastic leukemia
Mediastinal mass
Potentially curable in young patients