CH6 - 2) Acute Leukemia Flashcards Preview

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Flashcards in CH6 - 2) Acute Leukemia Deck (38)
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How does ATRA work?

It binds the altered receptor and causes the blasts to mature (and eventually die)


What is acute monocytic leukemia?

Proliferation of monoblasts; usually lack MPO


In acute monocytic leukemia what do blasts characteristically do?

infiltrate gums


What is acute megakaryoblastic leukemia?

Proliferation of megakaryoblasts; lack MPO


What is acute monocytic leukemia associated with?

Down syndrome (usually arises before the age of 5)


What is myelodysplastic syndrome?

acute myeloid leukemia may also arise from pre-existing dysplasia = myelodysplastic syndromes, especially with prior exposure to alkylating agents or radiotherapy


What do myelodysplastic syndromes usually present with?

cytopenias, hypercellular bone marrow, abnormal maturation of cells, and increased blasts < 20%


With myelodysplastic syndromes resulting in acute myeloid dysplastic syndrome what do most patients die from?

Most patients die from infection or bleeding, though some progress to acute leukemia.