Flashcards in CH6 - 2) Acute Leukemia Deck (38)
How does ATRA work?
It binds the altered receptor and causes the blasts to mature (and eventually die)
What is acute monocytic leukemia?
Proliferation of monoblasts; usually lack MPO
In acute monocytic leukemia what do blasts characteristically do?
What is acute megakaryoblastic leukemia?
Proliferation of megakaryoblasts; lack MPO
What is acute monocytic leukemia associated with?
Down syndrome (usually arises before the age of 5)
What is myelodysplastic syndrome?
acute myeloid leukemia may also arise from pre-existing dysplasia = myelodysplastic syndromes, especially with prior exposure to alkylating agents or radiotherapy
What do myelodysplastic syndromes usually present with?
cytopenias, hypercellular bone marrow, abnormal maturation of cells, and increased blasts < 20%