CH6 - 2) Acute Leukemia Flashcards Preview

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Flashcards in CH6 - 2) Acute Leukemia Deck (38)
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31

How does ATRA work?

It binds the altered receptor and causes the blasts to mature (and eventually die)

32

What is acute monocytic leukemia?

Proliferation of monoblasts; usually lack MPO

33

In acute monocytic leukemia what do blasts characteristically do?

infiltrate gums

34

What is acute megakaryoblastic leukemia?

Proliferation of megakaryoblasts; lack MPO

35

What is acute monocytic leukemia associated with?

Down syndrome (usually arises before the age of 5)

36

What is myelodysplastic syndrome?

acute myeloid leukemia may also arise from pre-existing dysplasia = myelodysplastic syndromes, especially with prior exposure to alkylating agents or radiotherapy

37

What do myelodysplastic syndromes usually present with?

cytopenias, hypercellular bone marrow, abnormal maturation of cells, and increased blasts < 20%

38

With myelodysplastic syndromes resulting in acute myeloid dysplastic syndrome what do most patients die from?

Most patients die from infection or bleeding, though some progress to acute leukemia.