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PSA Prescribing Exam > Chapter 1 > Flashcards

Chapter 1 Flashcards

0
Q

P450 inhibitors

SICK

A

Sodium valproate
Isoniazid
Cimetidine
Ketonazole

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1
Q

P450 inhibitors

A 
Increase drug concentration
Sodium valproate
isoniazid
Cimetidine
Ketoconazole
Fluconazole
Alcohol (acute) / allopurinol
Chloramphenicol
Erythromycin
Sulphonamide
Disulfiram
Ciprofloxacin
Omeprazole
Metronidazole
Grapefruit
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2
Q

P450 inhibitors and on warfarin

A

Can cause INR to increase

May need to reduce warfarin dose

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3
Q

P450 inhibitors FACES

A 
Fluconazole
alcohol (acute)/allopurinol
Chloramphenicol
Erythromycin
Sulphonamides
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4
Q

P450 inhibitors

Dot com group

A 
Disulfiram
Ciprofloxacin
Omeprazole
Metronidazole
Grapefruit
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5
Q

P450 inducers
Effect on drug concentration
Drug to be aware of

A

Reduces drug concentration

Reduces effectiveness of cocp

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6
Q

P450 inducers

PCBRAS

A 
Phenytoin
Carbamazepine
Barbiturates
Rifampicin
Alcohol (chronic)
Sulphonylureas
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7
Q

Drug to increase for surgery

A

Steroids

- may need to double dose

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8
Q

Drugs to stop before surgery

I-LACK-OP

A

Insulin- variable depending on preparation
Lithium- stop day before
Anticoagulants/anti platelets - variable
COCP/HRT- stop 4 weeks prior to surgery
K sparing diuretics- on day of surgery
Oral hypoglycaemics- variable. But METFORMIN: stop if NBM, can cause lactic acidosis
perindopril and ACEi- day of surgery

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9
Q

Allopurinol

A

P450 enzyme inhibitor
Xanthine oxidase inhibitor
Used in hyperuricaemia to prevent gout.

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10
Q

Sodium valproate

A

Prevents rapid action potential firing
Used in seizures, migraines, mania
P450 inhibitor

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11
Q

Isoniazid

A

Antibiotic
Inhibits mycolic acid synthesis
Part of anti TB therapy
P450 inhibitor

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12
Q

Cimetidine

A

H2 antagonist used for PUD

P450 Enzyme inhibitor

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13
Q

Ketoconazole

A

Anti fungal

P450 inhibitor

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14
Q

Fluconazole

A

P450 inhibitor

Anti fungal

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15
Q

Acute alcohol consumption

A

P450 inhibitor

16
Q

Ciprofloxacin

A

Second generation fluroquinolone
Broad spectrum abx
Gram positive and negative

17
Q

Omeprazole

A

PPI
P450 inhibitor
Se: diarrhoea, nausea

18
Q

Erythromycin

A

Macrolide antibiotic and prokinetic (GI)
P450 inhibitor
Alternative to penicillin if allergy
Resp infections (mycoplasma/legionella/STIs)

19
Q

Sulphonamides

A

Antibiotic class
P450 inhibitor
Inhibit folate synthesis

20
Q

Metronidazole

A

Nitromidazole antibiotic
Inhibits nuclei. Acid synthesis
Anaerobes and Protozoa
P450 inhibitor

21
Q

Grapefruit

A

P450 inhibitor

Increases concentration of p450 metabolised drugs

PSA Prescribing Exam (6 decks)

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