Chapter 1: Amyloids Flashcards Preview

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Flashcards in Chapter 1: Amyloids Deck (6)
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1
Q

Two types of conformational diseases

A
  • Loss of function: Misfolded protein mess

- Gain of function: Aggregation

2
Q

Why amyloid structure could not be determined for a lonf time?

A

Amorphous, can’t use X-Ray

Not soluble, NMR is useless

3
Q

General structure of amyloid fibril

A

Beta-sheets parallel to each other and perpendicular to the fibril axis

4
Q

What does birefringence mean

A

Substance has a range of refractive indices

5
Q

What is the barrier for nucleation

A

Insufficient entropy loss compensation by gained molecular forces

6
Q

Nucleation-dependent polymerization

A

Aggregation occurs under critical concentration
At higher concentration, there is a lag before aggregation occurs
Adding a seed instantly starts aggregation