Chapter 10 Flashcards
Amphiphilic
Having both hydrophobic and hydrophilic regions, as in a phospholipid or a detergent molecule.
Cholesterol
Lipid molecule with a characteristic four-ring steroid structure that is an
important component of the plasma membranes of animal cells.
Ganglioside
Any glycolipid having one or more sialic acid residues in its structure;especially abundant in the plasma membranes of nerve cells.
Lipid Raft
Small region of the plasma membrane enriched in sphingolipids and
cholesterol.
Liposome
Artificial phospholipid bilayer vesicle formed from an aqueous suspension of phospholipid molecules.
Phosphoglyceride
The main type of phospholipid in animal cell membranes, with two fatty
acids and a polar head group attached to a three-carbon glycerol backbone.
T or F: Although lipid molecules are free to diffuse in the plane of the bilayer,
they cannot flip-flop across the bilayer unless enzyme catalysts called phospholipid translocators are present in the membrane.
True; The hydrophobic interior of the lipid bilayer acts as a barrier to the
passage of the hydrophilic lipid head groups that must occur during flipflop. The energetic cost of this movement effectively prevents spontaneous
flip-flop of lipids, so that it occurs extremely rarely in the absence of specific catalysts known as phospholipid translocators.
T or F: All of the common phospholipids—phosphatidylcholine, phosphatidylethanolamine,
phosphatidylserine, and sphingomyelin—carry a positively
charged moiety on their head group, but none carry a net positive charge.
True; The positively charged moieties in all cases are balanced by the negative charge on the phosphate group; thus, none of the common
phospholipids carries a net positive charge.
T or F: Glycolipids are never found on the cytoplasmic face of membranes in
living cells.
True; Glycolipids are synthesized in the lumen of the Golgi apparatus,
which is topologically equivalent to the outside of the cell, and cannot flip-flop across the bilayer.
Bacteriorhodopsin
Pigmented protein found in the plasma membrane of Halobacterium
halobium, where it pumps protons out of the cell in response to light.
Lectin
Protein that binds tightly to a specific sugar.
Carbohydrate Layer
The outer coat of a eukaryotic cell, composed of oligosaccharides linked
to intrinsic plasma membrane glycoproteins and glycolipids, as well as
proteins that have been secreted and reabsorbed onto the cell surface.
Spectrin
Abundant protein associated with the cytosolic side of the plasma membrane
in red blood cells, forming a rigid network that supports the membrane.
Multipass Transmembrane Protein
Protein whose polypeptide chain crosses the lipid bilayer more than
once.
Cortex
The complicated cytoskeletal network in the cytosol just beneath the plasma membrane.