Chapter 10 Cancer of the Reproductive System Flashcards Preview

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Flashcards in Chapter 10 Cancer of the Reproductive System Deck (9)
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1

Anatomy of the cervix consists of (2)

lower portion of uterus which is contiguous with upper portion of vagina

- exocervix & endocervix
- surrounded by paracervical tissues rich in lymph nodes

2

Premalignant cancer changes of cervix
1) Mild:
2) Moderate:
3) Severe:

1) Cervical intraepithelial neoplasia
2) Carcinoma in situ (CIS) (a group of abnormal cells)
3) invasive disease

3

Persistent infection of what virus is necessary for development of cervical cancer?

Oncogenic human papillomavirus (HPV)

-certain genotype of HPV are known to be oncogenic

4

Factors that contribute to contracting HPV

Smoking
Hx of STDs
Contraceptive use
Early onset of vaginal intercourse
Large # of sexual partners
Chronic immunosuppression

5

Location where most cases of invasive cervical cancer arise =

Transformation zone at the squamocolumnar junction

6

2 main histologic types

1) Squamous carcinoma (80%)
2) Adenocarcinoma (20%)

7

Cervical cancer is the ___ most common cancer in women worldwide

4th

8

Incidence of invasive cervical cancer in US has decreased significantly dt what test?

Pap smears

+ bimanual pelvic examination

9

Metastatic patterns of cervical cancer

1) Direct extension into (5)
2) ___ ___ metastases
3) Metastasis to (3) through hematologic route

1) parametrium, vagina, lower uterine segment, abdomen, other pelvic structures
2) lymph node
3) Lung, bone, liver