Chapter 3: Carcinogenesis Flashcards Preview

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Flashcards in Chapter 3: Carcinogenesis Deck (5)
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1

Cancer

A neoplasm characterized by the uncontrolled growth of anaplastic cells that tend to invade surrounding tissue and metastasize to distant sites

2

Proto-oncogenes

Genes that code for proteins involved in normal cell growth

When mutated, they may enable a cancer cell to be self sufficient in growth (gas pedal is stuck)

3

Ras

A commonly mutated proto oncogene, especially in pacreatic and colorectal cancers

A point mutation can change Ras from a proto-oncogene to an oncogene

4

Tumor suppressor genes

Genes in normal cells that control proliferation by preventing uncontrolled growth

When mutated, these genes no longer suppress proliferation (brake pedal stuck)

5

RB gene

Gene that normally inhibits cell division

This gene is mutated in childhood retinoblastoma and many lung, breast, bone cancers