Chapter 11- Local Anesthetic Drugs and Techniques Flashcards
1
Q
At rest, the concentration of sodium ions is ____ outside than inside the nerve
A
Highest
2
Q
What is the resting membrane potential (in mV)?
A
-70 mV
3
Q
What happens when nerve is stimualted, how is this called?
A
The permeability of the membrane to sodium ions increases transiently. It is called depolarization.
4
Q
When the membrane is depolarized, it results in an ____ of Na and an ____ of K from the cell.
A
Influx; efflux
5
Q
What is the mechanism of action of local anesthetics?
A
Enter the sodium channels inhibiting influx of sodium
6
Q
What are the chemical properties that determine local anesthetic effect? What are they correlated to? (4)
A
- Lipid solubility- Potency
- Dissociation constant- Time to onset
- Chemical linkage- Metabolism
- Protein binding- Duration
7
Q
True/False: Local anesthetics produce a dose-dependent CNS depression proportionate to their inheritent local anesthetic potency
A
True
