Chapter 11: Membrane Transport Flashcards

(47 cards)

1
Q

What are the 4 different groups of items that can be transported through the membrane via bilayer diffusion

A
  1. hydrophobic molecules
  2. small uncharged molecules
  3. large uncharged molecules
  4. ions
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2
Q

What are two types of passive transport proteins?

A
  1. transporters
  2. channels
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3
Q

This type of passive protein has a conformational change (opens/closes) when moving molecules across membranes

A

transporter

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4
Q

this type of passive protein is a (sometimes gated) pore that quickly moves molecules across membranes

A

channel

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5
Q

About what portion of a typical cell membrane consists of receptors?

A

1/15

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6
Q

What type of molecule movement across membranes produces a logarithmic curve of activity?

A

transporter-mediated

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7
Q

What type of molecule movement across membranes produces a linear curve of activity?

A

simple diffusion

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8
Q

What are the three types of active transport?

A
  1. coupled transport
  2. ATP-driven pumps
  3. Light-driven pumps
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9
Q

A type of transport where only a single molecule is moved across a membrane

A

uniport

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10
Q

A type of coupled transport where two molecules are moved in the same direction across a membrane

A

symport

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11
Q

a type of coupled transport where two molecules are moved in opposite directions across a membrane

A

anitport

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12
Q

(T/F) the molecules moved in coupled transport are always going against their gradients

A

False

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13
Q

What essential basal/lateral transport proteins are found in gut lumen cells?

A
  1. Na+/K+ pumps
  2. passive glucose channels
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14
Q

What essential apical transport proteins are found in the gut lumen cells?

A

Na+/glucose transporter

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15
Q

What is the purpose of the Na+/K+ pump in the basal/lateral portions of gut lumen cells?

A

maintains a low [Na+] inside the cell

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16
Q

What is the purpose of the passive glucose transporters found in the basal/lateral portions of gut lumen cells?

A

removes absorbed glucose from the cell into the blood

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17
Q

what is the purpose of Na+/glucose transporters found in the apical surface of gut lumen cells?

A

absorbs low [glucose] from the lumen

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18
Q

What are 4 types of ATP-driven pumps?

A
  1. P-type ATPase
  2. ABC transporters
  3. V-type H+ pump
  4. F-type ATP synthase
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19
Q

This type of ATP-driven pump undergoes conformational changes as it consumes ATP to move molecules against their concentration gradient

A

ABC transporters

20
Q

This is a turbine-like protein machine that consumes ATP to transport H+ ions across membranes

A

V-type H+ pump

21
Q

This is a turbine-like protein machine that conducts rotational catalysis to produce ATP while transporting H+ ions

A

F-type ATP synthase

22
Q

In these proteins, the energy-providing ATP hydrolysis is coupled to the ion transport of one or two ion species across membranes (with the gradient)

A

P-type ATPase

23
Q

[Na+] are typically higher where?

A

outside the cell

24
Q

[K+] are typically higher where?

A

inside the cell

25
[H+] is typically higher where?
inside the cell
26
Where does the ATP-binding domain of ATP-driven pumps have to be located to function properly
inner membrane
27
[Na+] gradients aid in the maintenance of what?
pH
28
This ATP-driven pump brings in 2K+ and pushes out 3 Na+
Na+/K+ pump
29
what is the range of Na+/K+ pumps per cell?
80,000-30,000,000
30
About how many cycles does the Na+/K+ pump complete per minute
1,500-5,000 cycles/min
31
What are the levels of control for activity does the Na+/K+ pump undergo?
1. gene expression (slow) 2. regulatory domain (fast)
32
The initial state of the Na+/K+ pump cycle is called what?
E1
33
Once ATP binds to the Na+/K+ pump, what is the complex called?
E1 + ATP
34
How many ATP binding domains are present in ABC transporters?
2
35
How do bacterial cells uses ABC transporters?
bring large molecules into cell
36
How do eukaryotes use ABC transporters?
remove small molecules from cell
37
Whats an example of an ABC pump?
MDR (multiple drug resistant) pump
38
What 2 things are affected by [H+]?
1. ATP synthase 2. amino acids (proteins)
39
The functions of metabolism generally do what to pH?
decreases; more acidic
40
What are 3 examples of pH-regulating transporters?
1. Sodium/proton exchanger 2. Sodium-driven chloride ion/bicarbonate exchanger 3. sodium-independent chloride/bicarbonate exchanger
41
This is a pH-regulating transporter that utilizes high exterior [Na+] to export H+ ions from the cell (antiport fashion)
sodium/proton exchanger
42
This is a pH-regulating transporter that uses Na+ to facilitate the transport of bicarbonate into the cell (symport). This then allows for the export of Cl- and H+ ions (symport)
Sodium-driven chloride ion/bicarbonate exchanger
43
How many bicarbonates are imported with a Na+ ion in a Sodium-driven chloride ion/bicarbonate exchanger?
2-3 bicarbonates
44
How many H+ ions are eliminated with one Na+ ion via the sodium-driven chloride ion/bicarbonate exchanger
2 H+ ions
45
This is a pH-regulating transporter that exports bicarbonate and imports Cl- ions
sodium-independent chloride/bicarbonate exchanger
46
Why is the chloride/bicarbonate exchanger not preferred?
removes buffering bicarbonate
47
When is the chloride/bicarbonate exchanger typically used?
with high pH environments (low [H+])