Chapter 12 Flashcards
What is the difference between an agonist and an antagonist?
An agonist mimics the ligand and binds like the ligand would
An antagonist binds to the receptor, but doesn’t trigger activation. It essentially blocks the receptor off from the ligand or an agonist
Scatchard analysis is a plot describing _____
The ligand and receptor affinity
What are the five generic steps to biosignaling?
Specificity, Amplification, Modularity, Desensitization/adaptation, Integration
In biosignaling, specificity refers to:
Receptors are highly specific and will only bind to the correct molecule
In biosignaling, amplification refers to:
Once one enzyme is activated, it will activate other enzymes and so on. This causes a cascade of more and more enzymes being activated (occurs geometrically, like a pyramid)
In biosignaling, modularity refers to:
The ability for different complexes to work with each other in signaling. They are turned on by each other, but do different things
In biosignaling, desensitization/adaptation refers to:
At a certain point, a feedback loop will activate that tells the receptor to turn off or removes it from the cells surface
In biosignaling, integration refers to:
When signals have the opposite effect of each other, they must be able to coexist. The output is then dependent on the combination of signals from these receptors
Receptors tend to have a ______ affinity for their ligans
High
What is the basic idea of G protein coupled receptors?
When an external ligand binds to the receptor, the receptor activates the binding of intracellular GTP protein, which activates an intracellular secondary messenger
Receptors are normally ______ membrane proteins, and have a ligand binding domain and _______ domain (normally a kinase)
Integral
Catalytic
