Flashcards in Chapter 12 - Basic Principles of Neuropharmacology Deck (23):
Neuropharmalogic agents can be divided into what two broad categories
1. Central nervous system drugs
2. Peripheral nervous system drugs
Process by which information is carried across the gap between the neuron and the postsynaptic cell.
Process of conducting an action potential down the axon of the neuron.
Synaptic transmission requires the release of _________ molecules from the axon terminal followed by binding of these molecules to receptors at the _______
Neurotransmitter : postsynaptic cell
Series of events is initiated in the postsynaptic cell, leading to a change in its behavior
Most Neuropharmalogic agents act by altering ______
Why do drugs usually target synaptic transmission?
Because drugs that alter synaptic transmission can produce effects that are much more selective than those produced by drugs that alter Axonal conduction
Are drugs that act by altering axonal conduction very selective?
Recall that the process of conducting an impulse along an axon is essentially the same in all neurons. -- so it basically affects conduction in all nerves to which it has access.
Give an example of a drug that works on axonal conduction
Synaptic transmission can produce effects that are _______
The study of drugs that alter processes controlled by the nervous system
Why are drugs that Alter synaptic transmission produce effects that are highly selective?
Bc synapses, unlike axons differ from one another
The effects of Neuropjarmalogic drugs depend on altering ________
What are the 5 steps of synaptic transmission?
1. Transmitter synthesis
2. Transmitter storage
3. Transmitter release
4. Receptor binding
5. Termination of transmission
Transmitter storage takes place in the _____
Release of transmitter is triggered by __________
The arrival of an action potential at the axon terminal
Transmitter can be removed from the synaptic gap by what three processes?
2. Enzymatic degradation
Drugs that interfere with transmitter storage will cause receptor activation _____
A principal example of drugs that bind to receptors and thereby enhance the actions of a natural transmitter are the ________
Drugs can interfere with the termination of transmitter action by what two mechanisms
1. Blockade of transmitter reuptake
2. Inhibition of transmitter degradation
Activation of beta1 receptors cause______
1.Increased heart rate
2.Increase force of cardiac contraction
Activation of beta2 receptors cause______
1. Bronchial dilation
2. Elevation of blood glucose levels