Chapter 12 - Basic Principles of Neuropharmacology Flashcards Preview

Nu 578: Ch 4-19 Exam 1 > Chapter 12 - Basic Principles of Neuropharmacology > Flashcards

Flashcards in Chapter 12 - Basic Principles of Neuropharmacology Deck (23):
1

Neuropharmalogic agents can be divided into what two broad categories

1. Central nervous system drugs
2. Peripheral nervous system drugs

2

Synaptic transmission

Process by which information is carried across the gap between the neuron and the postsynaptic cell.

3

Axonal conduction

Process of conducting an action potential down the axon of the neuron.

4

Synaptic transmission requires the release of _________ molecules from the axon terminal followed by binding of these molecules to receptors at the _______

Neurotransmitter : postsynaptic cell

5

Transmitter-receptor binding

Series of events is initiated in the postsynaptic cell, leading to a change in its behavior

6

Most Neuropharmalogic agents act by altering ______

Synaptic transmission

7

Why do drugs usually target synaptic transmission?

Because drugs that alter synaptic transmission can produce effects that are much more selective than those produced by drugs that alter Axonal conduction

8

Are drugs that act by altering axonal conduction very selective?

No

Recall that the process of conducting an impulse along an axon is essentially the same in all neurons. -- so it basically affects conduction in all nerves to which it has access.

9

Give an example of a drug that works on axonal conduction

Local anesthetics

10

Synaptic transmission can produce effects that are _______

Highly effective

11

Neuropharmacology

The study of drugs that alter processes controlled by the nervous system

12

Why are drugs that Alter synaptic transmission produce effects that are highly selective?

Bc synapses, unlike axons differ from one another

13

The effects of Neuropjarmalogic drugs depend on altering ________

Receptor activity

14

What are the 5 steps of synaptic transmission?

1. Transmitter synthesis
2. Transmitter storage
3. Transmitter release
4. Receptor binding
5. Termination of transmission

15

Transmitter storage takes place in the _____

Vesicles

16

Release of transmitter is triggered by __________

The arrival of an action potential at the axon terminal

17

Transmitter can be removed from the synaptic gap by what three processes?

1. Reuptake
2. Enzymatic degradation
3. Diffusion

18

Drugs that interfere with transmitter storage will cause receptor activation _____

Decrease

19

A principal example of drugs that bind to receptors and thereby enhance the actions of a natural transmitter are the ________

Benzodiazepines

20

Drugs can interfere with the termination of transmitter action by what two mechanisms

1. Blockade of transmitter reuptake
2. Inhibition of transmitter degradation

21

Activation of beta1 receptors cause______

1.Increased heart rate
2.Increase force of cardiac contraction

22

Activation of beta2 receptors cause______

1. Bronchial dilation
2. Elevation of blood glucose levels

23

Drugs that block transmitter reuptake ________ receptor activation

Increase