Flashcards in Chapter 18 - Adrenergic Drugs Deck (21):
the adrenergic antagonists can be neatly divided into two major groups
1. alpha-adrenergic blocking agents
2. beta-adrenergic blocking agents
Alpha antagonists lower blood pressure by causing vasodilation by blocking ____ receptors on arterioles and veins
In response to venous ______, return of blood to the heart decreases, thereby decreasing cardiac output, which in turn _____ arterial pressure.
dilation ; reduces
Overdose with an alpha-adrenergic agonist (eg, epinephrine) can produce _____
hypertension. It is caused by excessive activation of alpha 1 receptors on blood vessles
How do you reverse high blood pressure from overdose of an alpha-adrenergic agonist?
use an alpha-blocking agent
If an IV line containing an alpha agonist becomes extravasated, necrosis can occur secondary to _____
intense local vasoconstriction
What drug can be given to block vasoconstriction from infiltration?
phentolamine (aphpa-adrenergic antagonist)
______ results from proliferation of cells in the prostate gland
Symptoms of BPH can be controlled with drugs that block ______
alpha 1 receptors (causes reduced contraction of smooth muscles in the prostatic capsule and bladder neck.
catecholamine-secreting tumor derived from cells of the sympathetic nervous system. (usually in adrenal medulla)
The principal cause of hypertension is activation of _____ receptors on blood vessels, although activation of beta1 receptors on the heart can also contribute
________ disease is a peripheral vascular disorder characterized by vasospasm in the toes and fingers.
_____ blockers can supress symptoms by preventing alpha-mediated vasoconstriction
The most significant adverse effects of the alpha-adrenergic antagonists result from blockade of
alpha 1 receptors
______ is the most serious adverse response to alpha-adrenergic blockade
The cause of orthostatic hypotension is blockade of alpha receptors on ____
Alpha-adrenergic antagonists can increase heart rate by triggering the
activation of ______ receptors is required for ejaculation
(nonselective) beta blockers (eg, propranolol), which block beta1 and beta2 receptors are ______ generation
(cardioselective) beta blockers (eg, metoprolol), which produce selective blockade of beta1 receptors (at usual doses) are _______ generation