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.Pharmacology > Chapter 14 > Flashcards

Chapter 14 Flashcards

1
Q

Hallmark of Alzheimer disease

A

Degeneration of particular cholinergic pathways (Acetylcholine)

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2
Q

Used to treat conditions like: depression, schizophrenia, anxiety, and Parkinson’s disease

A

Drugs affecting the concentration of Monoamine neurotransmitters

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3
Q

Has implication in the pathophysiology of schizophrenia and Parkinson’s

A

Dopamine

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4
Q

3 major DA-containing pathways in the CNS

A
  • nigrostriatal
  • mesocortical/mesolimbic
  • tuberoinfundibular
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5
Q

Drug

Clonidine

A
  • Antihypertensive
  • alpha 2 receptor agonist (adrenergic)
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6
Q

Enzyme that converts NE to Epi

A

Phenylethanolamine-N-methyltransferase

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7
Q

A therapeutic target for obesity, movement disorders, schizophrenia, ADHD, and wakefulness

A

H3 receptor (Histamine)

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8
Q

Orphan drug status for treatment of narcolepsy

A

Inverse agonist at the H3 receptor

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9
Q

Receptor with the highest affinity for the trace amine - tyramine, beta-phenylephrine, and octopamine

A

TA1 or TAAR 1

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10
Q

Drug

Morphine

A
  • plant alkaloid
  • selective for opioid receptor
  • peptide neurotranmitter
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11
Q

Drug

Marijuana

A
  • stimulate appetite via activation of the CB1 receptor
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12
Q

Drug

Rimonabant

A
  • inverse agonist of the CB1
  • anoretic
  • adverse effects include suicidality and depression
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13
Q

CB1 receptor agonist effects

A
  • stimulate appetite
  • treat nausea caused by chemotherapy
  • reduce pain
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14
Q

Drug

Dronabinol

A
  • receptor CB1 agonist
  • treat nausea caused by cancer or chemotherapy
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15
Q

Drug

Nabilone

A
  • CB1 receptor agonist
  • reduce pain
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16
Q

Drug

Baclofen

A
  • skeletal muscle relaxant
  • psychoactive drug GHB
  • sometimes used to treat narcolepsy
  • GABA agonist
17
Q

Agonist of glycine receptors

A

Taurine and beta-alanine

18
Q

When ischemia or hypoglycemia in the brain leads to a massive release and impaired reuptake of glutamate

A

Glutamate - mediated excitotoxicity

19
Q

Agent for sedation and control of convulsions

A

Benzodiazapine

20
Q

Drug

Benztropine mesylate

A
  • muscarinic antagonist
  • used for Parkinson disease and drug-induced extrapyramidal symptoms

.Pharmacology (55 decks)

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