Chapter 17: Aging and Cognition Flashcards

(43 cards)

1
Q

two groups of psych problems of older adults

A
  1. disorders COMMON in people of all ages but are not connected to the process of aging
    - depression, anxiety, SUD
  2. disorders of cognition that RESULT FROM BRAIN IRREGULARITIES
    - delirium, mild neurocognitive disorders, major neurocognitive disorders
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2
Q

older adults (ages)

A

65-70 and older

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3
Q

depression in later life

A
  • common
  • assessment can be hard b/c they don’t like to talk about feelings (generational thing)
  • p rate: 20%
  • higher among women, people 85+, and people living in nursing homes
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4
Q

___% of old people display bipolar disorder?

A

1%

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5
Q

predictors of depression in the elderly

A
  • Hx of depression
  • poor health
  • disability
  • insomnia
  • loss
  • low social support
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6
Q

is suicidality a concern in older adults?

A

yes

old people kill themselves more (not just attempts, but actually committing suicide)

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7
Q

___% of older adults commit suicide

A

25%

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8
Q

depression Tx

A

CBT
interpersonal therapy
antidepressants

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9
Q

risk of antidepressants in older adults

A

they require different meds/doses because their metabolization changes

higher risk of causing cog impairments

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10
Q

anxiety in later life

A
  • common
  • p rate: 10%
  • lifetime p rate: 7%

common Tx:
- CBT
- psychotropic meds (risk: may cause cog impairments)

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11
Q

disorders of cognition

A

leading Dx:
delirium, mild neurocognitive disorder, major neurocognitive disorder

** most common neurocog disorder is Alzheimer’s

** the cause of forgetting IS physiologically/neurologically based

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12
Q

delirium (aka clouding of consciousness)

A

a state of massive confusion over a short period of time (difficulty concentrating, focusing, and thinking sequentially)
**reversible if treated

  • 18-35% of elderly in hospitals (for general medical issue) have Sx of delirium
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13
Q

delirium (p rates)

A

nonelderly pop: less than 0.5%
people over 55: 1%
people over 85: 14%

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14
Q

causes of delirium

A

fever, certain diseases and infections (e.g. UTI/bladder infections), poor nutrition, head injuries, strokes, stress, and intoxication

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15
Q

Sx of delirium

A

disoriented
hallucinations (visual)
lack of concentration
lack of attention

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16
Q

neurocognitive disorders

A

cog. mishaps are normal with aging, BUT some people experience memory and/or other cog issues that are more extensive and problematic (resulting in mild/major neurocog disorder)
- may also have changes in behav or personality
- can be caused by nutritional or metabolic problems

e.g. word-finding problems (not normal ‘tip of the tongue’ but genuinely doesn’t know it)

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17
Q

when can neurocog disorders be officially Dx

A

after death to see the extent of brain damage

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18
Q

what is dementia

A

global deterioration of mental functioning (memory is always impaired), other areas may include:
- attention, language, mood, self-care, reasoning and judgment, visual-spatial abilities, and physical function

19
Q

what is the most common neurocog disorder

A

Alzheimer’s
2/3 of all cases of dementia or neurocog disorder

20
Q

major neurocog disorder

A

decline in cog function is SUBSTANTIAL, interfering with one’s ability to be independent

21
Q

mild neurocog disorder

A

decline in cog function is MODEST and does NOT interfere with one’s ability to be independent

22
Q

onset of Alzheimer’s

A
  1. early onset/familial (before 65)
    - has a clear set of genetics
  2. late onset/sporadic (after 65)
    - combo of genetics, lifestyle, and environmental factors

only 10% of cases are early onset

avg time between onset and death is 4-8 years (some can survive for up to 20 years)

23
Q

Alzheimer’s

A

usually begins with mild memory problems, lapses of attention, and difficulties in language/communications

**struggles to differentiate between day/night

24
Q

physical markers of Alzheimer’s

A
  1. EXCESSIVE amyloid/senile plaques
    - sphere-shaped deposits of beta-amyloid protein that form in spaces between cells in the hippocampus, cerebral cortex, and other brain regions/vessels
  2. EXCESSIVE neurofibrillary tangles
    - twisted tau protein fibers found within cells of the hippocampus

ALSO the NTs:
acetylcholine and glutamate
are low in supply and there are IRREGULARITIES IN BREAKDOWN OF CALCIUM

25
what do scientists believe is the catalyst of Alzheimer's
EXCESSIVE neurofibrillary tangles - twisted tau protein fibers found within cells of the hippocampus ******MAIN PART: when the protein breaks down, the neurons effectively die
26
possible causes of Alzheimer's
- genetics - protein theories (tau/beta-amyloid) - ApoE4 as a risk factor - exposure to toxins like zinc and lead - autoimmune theory - prion theory
27
what are the causes of early onset/familial Alzheimer's
genetics and the abnormal production of two proteins: - beta-amyloid precursor protein - presenilin protein
28
what are the causes of late onset/sporadic Alzheimer's
a combination of genetics, environmental, and lifestyle factors - the inheritance of ApoE4 has been implicated in late onset Alzheimer's
29
ApoE4 (potential cause of late onset Alzheimer's)
3 versions (genetically) - E2- rarest, preventative aspects - E3- neutral - E4- increased risk of Alzheimer's 1 copy of E4 = 2x likelihood 2 copies of E4= 10x likelihood
30
autoimmune theory (Alzheimer's)
Alzheimer's is an autoimmune disease - beta-amyloid overrides, overproduces, and attacks neurons
31
prion protein (Alzheimer's)
proteins have folded over oneself Sx of Alzheimer's are similar to mad cow disease, which is implicated by this
32
the aging brain (pic)
33
drug Tx for Alzheimer's
some meds will slow progression in early stages (e.g. Tacrine, Aricept, Namenda) - these increase availability of acetylcholine, and others increase glutamate
34
is there a cure for Alzheimer's
NO
35
alternative Tx of Alzheimer's
antioxidants vitamin E estrogen (for postmenopausal women) ibuprofen omega 3 fish oils
36
anti-amyloid drugs (Alzheimer's)
2 drugs approved by FDA (injected) - they reduce amyloid plaques BUT research is mixed about whether it actually helps cog function side effects: - brain bleeds - brain inflammation
37
prevention of Alzheimer's
- exercise at least 3x/week - treat risk factors for heart disease (high cholesterol, obesity, smoking, high fat diet, inactivity, etc.) - supplements (e.g. antioxidants, omega 3 fish oils) - fruit/veg juice 5 mornings/wk - USE IT OR LOSE IT
38
vascular dementia
caused by a series of mini strokes; sudden onset and sporadic, stepwise decline (not a gradual decline, but they wake up and suddenly are a lot worse) - second most common type of dementia - Dx by clinical presentation and brain scans - memory problems are big - likely to have confusion, slurred speech, writing impairment, numbness on one side of body
39
Pick's disease (another neurocog disorder)
a rare disorder that affects the frontal and temporal lobes - clinically similar to Alzheimer's
40
Creutzfeldt-Jakob disease (another neurocog disorder)
caused by misshaped proteins, this disease has Sx that include body spasms
41
Huntington's Disease (can lead to dementia)
inherited progressive disease in which memory problems worsen over time, along with personality changes, mood difficulties, and movement problems
42
Parkinson's (can lead to dementia)
slowly progressive neurological disorder marked by tremors, rigidity, and unsteadiness that can cause dementia - a lack of dopamine is directly involved due to the degeneration of dopamine producing neurons in the body
43
neurocog disorder due to Lewy Body Disease (another neurocog disorder)
clumps of protein deposits (Lewy Bodies) build up with neurons - memory problems, movement difficulties, visual hallucinations, sleep problems (REM sleep behavior disorder) ***third most common type of neurocog disorder