Flashcards in Chapter 18- Lipid III Plasma Lipoproteins Deck (29):
Principle TG carriers are
Chylomicrons and VLDL
List the least dense lipoprotein to most dense
Chylomicron -> VLDL -> IDL -> LDL -> HDL2 -> HDL3 -> Lp(a)
regulation of hepatic lipase
+ to androgens, - to increase level of estrogens
Cholesteryl esters are transferred to VLDL and LDL via?
Apo D and cholesteryl ester transfer protein (CETP)
a defect in the ABC1 transporter is associated with what diseases?
Tangier's disease, CF, early onset macular degeneration, adrenoleuko dystrophy, zellweger syndrome, progressive familial intrahepatic cholestasis
Apo A-II on larger HDL particles does what?
inhibits hydrolysis of HDL-TG and PL by hepatic lipase
Lipoproteins present in excess for hyperlipoproteinemia phenotype I?
Lipoproteins present in excess for hyperlipoproteinemia phenotype IIa?
Lipoproteins present in excess for hyperlipoproteinemia phenotype IIb?
LDL + VLDL
Lipoproteins present in excess for hyperlipoproteinemia phenotype III?
Lipoproteins present in excess for hyperlipoproteinemia phenotype IV?
Lipoproteins present in excess for hyperlipoproteinemia phenotype V
Chylomicrons + VLDL
Abetalipoproteinemia characterized by a defect in
no chylomicrons, VLDL, or LDL formed d/t defect in the loading of Apo B with lipid
Familial alpha-lipoprotein deficiency includes
Tangier's disease, Fish-eye disease, Apo AI deficiencies
Familial alpha-lipoprotein deficiency characterized by
low or near absent HDL
Familial lipoprotein lipase deficiency type 1 characterized by
hypertriacylglycerolemia d/t deficient LPL or Apo C-II deficiency causing inactive LPL
Familial hypercholesterolemia type IIa characterized by
defective LDL receptors or mutation in ligand region of Apo B-100
Familial hyperlipoproteinemia type III characterized by
deficiency of remnant clearance by liver d/t abnormal Apo E. its lack isoform E3 and E4 and only have E2 which does not react with receptor
Familial hyperalphalipoproteinemia characterized by
increased concentrations of HDL
Familial hypertriacylglycerolemia (type IV) characterized by
overproduction of VLDL also. with glucose intolerance
Hepatic lipase deficiency characterized by
deficiency of the enzyme leads to accum. of large TAG rich HDL and VLDL remnants
Familial LCAT deficiency characterized by
absence of LCAT results in block of reverse cholesterol transport. HDL remains nascent disks unable to take up cholesterol
Familial lipoprotein(a) excess characterized by
Lp(a) consists of 1 mol of LDL attached to 1 mol apo(a). Apo(a) shows structural homologies to plasminogen
plasma LDL cholesterol level can be calculated by
total cholesterol - (VLDL cholest. + HDL cholest.)
total cholesterol - (TG/5 + HDL cholest.)
after 12-24 hour fast
Cholestyramine & colestipol mechanism:
bile acid sequestant - nonabsorbable resins, interrupt enterohepatic circulation of bile acids
Nicotinic acid mechanism:
reduce VLDL & LDL by inhibiting hepatic secretion of VLDL & by suppressing mobilization of FA
Clofibrate & gemfibrozil mechanism:
fibric acid derivatives - promote rapid turnover of VLDL by activating lipoprotein lipase, gemfibrozil inhibit VLDL secretion
reduce plasma cholesterol level but no effect on TG, act via blockage of intestinal cholesterol transport, HDL cholesterol levels are reduced by this drug