Chapter 18- Lipid III Plasma Lipoproteins Flashcards Preview

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Flashcards in Chapter 18- Lipid III Plasma Lipoproteins Deck (29):
1

Principle TG carriers are

Chylomicrons and VLDL

2

List the least dense lipoprotein to most dense

Chylomicron -> VLDL -> IDL -> LDL -> HDL2 -> HDL3 -> Lp(a)

3

regulation of hepatic lipase

+ to androgens, - to increase level of estrogens

4

Cholesteryl esters are transferred to VLDL and LDL via?

Apo D and cholesteryl ester transfer protein (CETP)

5

a defect in the ABC1 transporter is associated with what diseases?

Tangier's disease, CF, early onset macular degeneration, adrenoleuko dystrophy, zellweger syndrome, progressive familial intrahepatic cholestasis

6

Apo A-II on larger HDL particles does what?

inhibits hydrolysis of HDL-TG and PL by hepatic lipase

7

Lipoproteins present in excess for hyperlipoproteinemia phenotype I?

Chylomicrons

8

Lipoproteins present in excess for hyperlipoproteinemia phenotype IIa?

LDL

9

Lipoproteins present in excess for hyperlipoproteinemia phenotype IIb?

LDL + VLDL

10

Lipoproteins present in excess for hyperlipoproteinemia phenotype III?

beta-VLDL

11

Lipoproteins present in excess for hyperlipoproteinemia phenotype IV?

VLDL

12

Lipoproteins present in excess for hyperlipoproteinemia phenotype V

Chylomicrons + VLDL

13

Abetalipoproteinemia characterized by a defect in

no chylomicrons, VLDL, or LDL formed d/t defect in the loading of Apo B with lipid

14

Familial alpha-lipoprotein deficiency includes

Tangier's disease, Fish-eye disease, Apo AI deficiencies

15

Familial alpha-lipoprotein deficiency characterized by

low or near absent HDL

16

Familial lipoprotein lipase deficiency type 1 characterized by

hypertriacylglycerolemia d/t deficient LPL or Apo C-II deficiency causing inactive LPL

17

Familial hypercholesterolemia type IIa characterized by

defective LDL receptors or mutation in ligand region of Apo B-100

18

Familial hyperlipoproteinemia type III characterized by

deficiency of remnant clearance by liver d/t abnormal Apo E. its lack isoform E3 and E4 and only have E2 which does not react with receptor

19

Familial hyperalphalipoproteinemia characterized by

increased concentrations of HDL

20

Familial hypertriacylglycerolemia (type IV) characterized by

overproduction of VLDL also. with glucose intolerance

21

Hepatic lipase deficiency characterized by

deficiency of the enzyme leads to accum. of large TAG rich HDL and VLDL remnants

22

Familial LCAT deficiency characterized by

absence of LCAT results in block of reverse cholesterol transport. HDL remains nascent disks unable to take up cholesterol

23

Familial lipoprotein(a) excess characterized by

Lp(a) consists of 1 mol of LDL attached to 1 mol apo(a). Apo(a) shows structural homologies to plasminogen

24

plasma LDL cholesterol level can be calculated by

total cholesterol - (VLDL cholest. + HDL cholest.)
or
total cholesterol - (TG/5 + HDL cholest.)

after 12-24 hour fast

25

Cholestyramine & colestipol mechanism:

bile acid sequestant - nonabsorbable resins, interrupt enterohepatic circulation of bile acids

26

Nicotinic acid mechanism:

reduce VLDL & LDL by inhibiting hepatic secretion of VLDL & by suppressing mobilization of FA

27

Clofibrate & gemfibrozil mechanism:

fibric acid derivatives - promote rapid turnover of VLDL by activating lipoprotein lipase, gemfibrozil inhibit VLDL secretion

28

Probucol mechanism:

reduce plasma cholesterol level but no effect on TG, act via blockage of intestinal cholesterol transport, HDL cholesterol levels are reduced by this drug

29

Statins mechanism:

competitive inhibitor of HMG-CoA reductase - inhibit the regulatory step in biosynthesis of cholesterol, lower serum cholesterol & LDL cholesterol by inhibition of hepatic cholesterol synthesis, by up-regulating LDL receptor activity