Chapter 186 - Systemic and Topical Antibiotics

Question 1

TABLE 186-3
Contraindications and Precautions of Penicillin Therapy

Fill in the blanks

Known _____ to penicillin

Answer 1

Known hypersensitivity to penicillin

Question 2

TABLE 186-3
Contraindications and Precautions of Penicillin Therapy

Fill in the blanks

_____ penicillin levels with probenecid and disulfiram

Answer 2

Increased penicillin levels with probenecid and disulfiram

Question 3

TABLE 186-3
Contraindications and Precautions of Penicillin Therapy

Fill in the blanks

_____ effect of methotrexate and warfarin

Answer 3

Enhanced effect of methotrexate and warfarin

Question 4

TABLE 186-3
Contraindications and Precautions of Penicillin Therapy

Fill in the blanks

Use with caution in patients with _____ impairment

Answer 4

Use with caution in patients with renal impairment

Question 5

TABLE 186-5
Adverse Effects

PREGNANCY CLASS
Penicillins

Answer 5

B

Question 6

TABLE 186-5
Adverse Effects

PREGNANCY CLASS
Cephalosporins

Answer 6

B

Question 7

TABLE 186-5
Adverse Effects

PREGNANCY CLASS
Tetracyclines

Answer 7

D

Question 8

TABLE 186-5
Adverse Effects

PREGNANCY CLASS
Fluoroquinolones

Answer 8

C

Question 9

TABLE 186-5
Adverse Effects

PREGNANCY CLASS
Trimethoprim-sulfamethoxazole

Answer 9

D

Question 10

TABLE 186-5
Adverse Effects

PREGNANCY CLASS
Lincosamides (clindamycin)

Answer 10

B

Question 11

TABLE 186-5
Adverse Effects

PREGNANCY CLASS
Macrolides

Answer 11

B/C

Question 12

TABLE 186-5
Adverse Effects

COMMON ADVERSE EFFECTS
Skin and nail hyperpigmentation

Answer 12

Minocycline

Question 13

TABLE 186-5
Adverse Effects

COMMON ADVERSE EFFECTS
Dysgeusia

Answer 13

Clarithromycin

Question 14

TABLE 186-5
Adverse Effects

UNCOMMON ADVERSE EFFECTS
Neurotoxicity (high dose)

Answer 14

Penicillins

Question 15

TABLE 186-5
Adverse Effects

UNCOMMON ADVERSE EFFECTS
Pulmonary infiltrate with eosinophilia (PIE)

Answer 15

Penicillins

Question 16

TABLE 186-5
Adverse Effects

UNCOMMON ADVERSE EFFECTS
Serum sickness-like reaction (2)

Answer 16

Cefaclor
Cefprozil

Question 17

TABLE 186-5
Adverse Effects

UNCOMMON ADVERSE EFFECTS
Pseudocholelithiasis

Answer 17

Ceftriaxone

Question 18

TABLE 186-5
Adverse Effects

UNCOMMON ADVERSE EFFECTS
Photosensitivity

Answer 18

Doxycycline

Question 19

TABLE 186-5
Adverse Effects

UNCOMMON ADVERSE EFFECTS
Vestibular toxicity

Answer 19

Minocycline

Question 20

TABLE 186-5
Adverse Effects

UNCOMMON ADVERSE EFFECTS
Blood dyscrasias (long term use)

Answer 20

Tetracyclines

Question 21

TABLE 186-5
Adverse Effects

UNCOMMON ADVERSE EFFECTS
Tendon rupture, arthropathy (in the immature)

Answer 21

Fluoroquinolones

Question 22

TABLE 186-5
Adverse Effects

UNCOMMON ADVERSE EFFECTS
Elevated hepatic transaminases (reversible)

Answer 22

Lincosamides (clindamycin)

Question 23

TABLE 186-7
Contraindications and Precautions of
Cephalosporin Therapy

Fill in the blanks

Known _____ to cephalosporin or penicillin

Answer 23

Known hypersensitivity to cephalosporin or penicillin

Question 24

TABLE 186-7
Contraindications and Precautions of
Cephalosporin Therapy

Fill in the blanks

_____ absorption of cefdinir with antacids and iron salts

Answer 24

Reduced absorption of cefdinir with antacids and iron salts

Question 25

TABLE 186-7 Contraindications and Precautions of Cephalosporin Therapy Fill in the blanks _____ cyclosporine levels with ceftriaxone and ceftazidime

Answer 25

Increased cyclosporine levels with ceftriaxone and ceftazidime

Question 26

TABLE 186-7 Contraindications and Precautions of Cephalosporin Therapy Fill in the blanks _____ effect of warfarin with cefotetan, cefamandole, cefoperazone, cefixime, and cefaclor

Answer 26

Altered effect of warfarin with cefotetan, cefamandole, cefoperazone, cefixime, and cefaclor

Question 27

TABLE 186-7 Contraindications and Precautions of Cephalosporin Therapy Fill in the blanks Impaired _____ excretion of most cephalosporins with probenecid

Answer 27

Impaired renal excretion of most cephalosporins with probenecid

Question 28

TABLE 186-9 Contraindications and Precautions of Tetracycline Therapy Fill in the blanks Patients with _____ failure (impaired excretion and antianabolic properties)

Answer 28

Patients with renal failure (impaired excretion and antianabolic properties)

Question 29

TABLE 186-9 Contraindications and Precautions of Tetracycline Therapy Fill in the blanks Photosensitivity (_____)

Answer 29

Photosensitivity (doxycycline)

Question 30

TABLE 186-9 Contraindications and Precautions of Tetracycline Therapy Fill in the blanks Nursing, pregnancy, and childhood years (_____ years of age)

Answer 30

Nursing, pregnancy, and childhood years (<9 years of age)

Question 31

TABLE 186-9 Contraindications and Precautions of Tetracycline Therapy Fill in the blanks _____ absorption by calcium, magnesium, aluminum (other cations), iron, sodium bicarbonate, and cimetidine

Answer 31

Impaired absorption by calcium, magnesium, aluminum (other cations), iron, sodium bicarbonate, and cimetidine

Question 32

TABLE 186-9 Contraindications and Precautions of Tetracycline Therapy Fill in the blanks _____ metabolism of doxycycline with the use of phenytoin, carbamazepine, barbiturates, and alcohol

Answer 32

Increased metabolism of doxycycline with the use of phenytoin, carbamazepine, barbiturates, and alcohol

Question 33

TABLE 186-9 Contraindications and Precautions of Tetracycline Therapy Fill in the blanks _____ insulin requirements in diabetic patients

Answer 33

Reduced insulin requirements in diabetic patients

Question 34

TABLE 186-9 Contraindications and Precautions of Tetracycline Therapy Fill in the blanks _____ serum levels of digoxin, lithium, and warfarin

Answer 34

Increased serum levels of digoxin, lithium, and warfarin

Question 35

TABLE 186-9 Contraindications and Precautions of Tetracycline Therapy Fill in the blanks Methoxyflurane anesthesia (_____ failure)

Answer 35

Methoxyflurane anesthesia (renal failure)

Question 36

TABLE 186-11 Contraindications and Precautions of Clindamycin Therapy Fill in the blanks _____ of neuromuscular blockade with tubocurarine and pancuronium

Answer 36

Enhancement of neuromuscular blockade with tubocurarine and pancuronium

Question 37

TABLE 186-11 Contraindications and Precautions of Clindamycin Therapy Fill in the blanks Possible _____ with erythromycin

Answer 37

Possible antagonism with erythromycin

Question 38

TABLE 186-11 Contraindications and Precautions of Clindamycin Therapy Give 2

Answer 38

Hepatic failure Colitis

Question 39

TABLE 186-15 Contraindications and Precautions of Fluoroquinolone Therapy Fill in the blanks _____ bioavailability with antacids (aluminum, magnesium, alum), iron, zinc, and sucralfate

Answer 39

Decreased bioavailability with antacids (aluminum, magnesium, alum), iron, zinc, and sucralfate

Question 40

TABLE 186-15 Contraindications and Precautions of Fluoroquinolone Therapy Fill in the blanks Inhibited theophylline and aminophylline metabolism (_____)

Answer 40

Inhibited theophylline and aminophylline metabolism (ciprofloxacin)

Question 41

TABLE 186-15 Contraindications and Precautions of Fluoroquinolone Therapy Fill in the blanks Tendon rupture (in patients with _____ disease, _____, or _____)

Answer 41

Tendon rupture (in patients with renal disease, hemodialysis, or steroid use)

Question 42

TABLE 186-15 Contraindications and Precautions of Fluoroquinolone Therapy Fill in the blanks _____ seizure threshold

Answer 42

Decreased seizure threshold

Question 42

TABLE 186-15 Contraindications and Precautions of Fluoroquinolone Therapy Fill in the blanks _____ warfarin and cyclosporine metabolism

Answer 42

Decreased warfarin and cyclosporine metabolism

Question 43

TABLE 186-17 Contraindications and Precautions of Trimethoprim-Sulfamethoxazole Therapy Fill in the blanks Severe reactions in patients with _____

Answer 43

Severe reactions in patients with HIV/AIDS

Question 44

TABLE 186-17 Contraindications and Precautions of Trimethoprim-Sulfamethoxazole Therapy Fill in the blanks _____ prothrombin time in patients on warfarin

Answer 44

Prolonged prothrombin time in patients on warfarin

Question 45

TABLE 186-17 Contraindications and Precautions of Trimethoprim-Sulfamethoxazole Therapy Fill in the blanks Contraindicated for patients on _____

Answer 45

Contraindicated for patients on methotrexate

Question 46

TABLE 186-18 Topical Antibiotics SAFETY Clindamycin

Answer 46

B

Question 46

TABLE 186-18 Topical Antibiotics SAFETY Mupirocin

Answer 46

B

Question 47

TABLE 186-18 Topical Antibiotics SAFETY Retapamulin

Answer 47

B

Question 48

TABLE 186-18 Topical Antibiotics For use in children >9 months of age only

Answer 48

Retapamulin

Question 49

TABLE 186-18 Topical Antibiotics SAFETY Bacitracin

Answer 49

C

Question 50

TABLE 186-18 Topical Antibiotics SAFETY Polymyxin B

Answer 50

C

Question 51

TABLE 186-18 Topical Antibiotics SAFETY Neomycin

Answer 51

D

Question 52

TABLE 186-18 Topical Antibiotics SAFETY Gentamicin

Answer 52

C

Question 53

TABLE 186-18 Topical Antibiotics SAFETY Silver sulfadiazine

Answer 53

B

Question 54

TABLE 186-18 Topical Antibiotics SAFETY Fusidic acid

Answer 54

Safe to use during pregnancy