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Hema > Chapter 19 > Flashcards

Chapter 19 Flashcards

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1
Q

Variations in size

A

Anisocytosis

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2
Q

Parameter that measures single cell size

A

Mean Cell Volume (MCV)

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3
Q

Parameter that measures variations in cell size

A

RBS distribution width (RDW)

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4
Q

Parameters used to identify the presence of anisocytosis

A

RDW & MCV

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5
Q

RBC that is less than 6 micrometer

A

Microcytic

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6
Q

Rbc that is greater than 8 micrometer

A

Macrocytic

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7
Q

Rbc that ranges from 6-8 micrometer

A

Normocytic

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8
Q

Disease associated with microcytic

A 
SITA 
Sideroblastic 
Iron deficiency 
Thalassemja 
Anemia of chronic dse
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9
Q

Disease associated with macrocytic

A 
VFMAC 
Vit B12 def
Folate def 
Megaloblastic anemia
Aplastic 
Chronic liver dse
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10
Q

Disease associated with normocytic

A

AHA
Acute post hemorrhagic anemia
Hemolytic anemia
Aplastic anemia

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11
Q

Microystis is due to?

A

Decreased hgb synthesis

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12
Q

Alteration in color

A

Anisochromia

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13
Q

It is the result of a defect in either nuclear maturation or stimulated erythropoiesis

A

Macrocystis

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14
Q

What are the three types of anisochromia

A

Hypochromia, normochromic, polychromatophilia

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15
Q

Disease assoc with normochromic

A

AHA

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16
Q

This stage of RBC maturation exhibits polychromatophilia

A

Polychromatophilic erythrocyte (Reticulocyte)

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17
Q

It has large, pale overall appearance and large central palloa

A

Hyprochromia

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18
Q

Disease associated with hypochromia

A

TIA
Thalassemia
Iron def anemia
Acute blood loss

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19
Q

General term for cells with different shape

A

Poikilocytes

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20
Q

Will you pas this sem?

A

Absolutely indeed

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21
Q

Variation in shape

A

Poikilocytosis

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22
Q

Poikilocyte that is evenly spaced pointed projection

With central pallor

A

Echinocyte

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23
Q

Other name for echinocyte

A

Burr cell

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24
Q

Other name for acanthocyte

A

Spurr cell

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25
Poikilocyte that is small and round. Sphere shape
Spherocyte
26
Disease associated with Burr cell
PUG Pyruvate kinase def Uremia Gastric carcinoma
27
Artifact in drying smear
Burr cell
28
Irregulary spaced projections | With no central pallow
Acanthocyte (spur cell)
29
Associated diseases of acanthocyte
``` HACS Hemolytic Abetalipoproteinemia Cirrhosis Splenectomy ```
30
Disease associated with spherocyte
``` HBHD Hereditary spherocytosis Burns Hemolytic Disseminated intravascular coagulation ```
31
These are group of fragmented erythrocytes
Schistocyte
32
3 types of schistocyte
Schizocyte Bite cells /keratocyte / helmet cell Blister cell
33
Associated diseases with schistocyte
MSR Microangiopathic hemolytic anemia Severe burns Renal graft rejection
34
Poikilocyte result of splenic pitting of heinz bodies
Bite and blister cells
35
Also known as target cell
Codocyte
36
Has one blunt projection
Dacryocyte
37
Central concentration of hemoglobin surrounded by colorless area with peripheral ring of hemoglobin
``` TAHOP Thalassemia Artifact Hemoglobinopathies Obstructive liver disease Post splenectomy ```
38
Slit like central pallor
Stomatocyte
39
Disease associated with dacryocyte
``` PPBMM primary myelofibrosis Pernicious anemia Beta thalassemia Myelophthisic anemia Megaloblastic anemia ```
40
Elongated cell with point on each end S shaped No central pallow
Sickle cell (drepanocyte)
41
Composition of HB C crystal
Hemoglobin C
42
Disease associated with mouth cell
``` HARE hereditary stomatocytosis Acquired stomatocytosis Rh null syndrome Electrolyte imbalance ```
43
Cigar shaped cell
Elliptocyte
44
Egg shaped
Ovalocyte
45
Disease associated with elliptocyte
``` MITH Myelophthisic anemia Iron deficiency anemia Thalassemia major Hereditary elliptocytosis ```
46
Hexagonal structure of dense hb within the membrane | Very red
Hemoglobin C crystal
47
Disease associated with drepanocyte
Sickle cell anemia | Sickle cell b-thalassemia
48
Composition of sickle cell
Hemoglobin S
49
Poikilocyte with finger like projections and may appear folded
Hemoglobin SC crystal
50
Disease associated with hb sc crystal
Hemoglobin sc disease
51
Dense hb protruding from the membrane
Hb SC crystal
52
Hemoglobin sc crystal composition
Hemoglobin SC
53
Associated disease of hb C crystal
Homozygous hemoglobin C disease
54
What are the rbc inclusion normally stained with Wright stain?
Basophilic stippling, cabot rings, howell jolly bodies, pappenheimer bodies
55
Rbc inclusion normally stained with supravital stain
Heinz bodies and hemoglobin H
56
It appears fine or coarse punctate granules and contains rna and mitochondrial remnants
Basophilic stippling
57
Associated disease with fine granules. ( basophilic)
Increased polychromatophilia
58
Associated disease with coarse granules ( basophilic stipp)
``` MALT Megaloblastic anemia Abnormal heme synthesis Lead poisoning Thalassemia ```
59
Composed of DNA. State its number per cell
Howell jolly bodies | 1-2
60
Associated disease of Cabot ring
MM Megaloblastic anemia Myelophthisic anemia
61
Has remnants of mitotic spindle and has an appearance of figure eight.
Cabot ring
62
Disease associated with howell jollybodies
``` PPHM Post splenectomy Pernicious anemia Hemolytic anemia Megaloblastic anemia ```
63
Howell jolly bodies are remnants of what rbc stage of maturation?
Orthochromic erythroblast
64
These are fine granules in clusters and is composed of iron
Pappenheimer bodies
65
pappenheimer stained with iron stain is called
Siderotic granules
66
Supravital stains
New methylene blue Brillian cresyl blue Methyl violet Crystal violet
67
Results from cell shrinkage or crenation
Echinocyte
68
Disease associated with heinz bodies
GUC G6PD def Uneven hemoglobin Congenital hemolytic anemia
69
Disease associated with hemoglobin H
Hb H disease
70
Disease associated with pappenheimer bodies
``` SSMHH Sideroblastic anemia Splenectomy Megaloblastic anemia Hemolytic anemia ```
71
Hemoglobin H composition
Hemoglobin beta-chains
72
Heinz bodies composition
Denatured hemoglobin

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