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Patho Fall 22 > Chapter 24: Disorders of WBC and Lymphoid Tissue > Flashcards

Chapter 24: Disorders of WBC and Lymphoid Tissue Flashcards

1
Q

What elements form blood?

A

*Red Blood Cells
*Platelets
*WBC

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2
Q

What makes up white blood cells?

A

*Granulocytes
*Monocyte and macrophage lineage
*Lymphocytes

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3
Q

Hematopoiesis:

A
  • The formation of blood cells
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4
Q

What is the lifespan of WBC?

A

13-20 Days

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5
Q

Where are hematopoiesis formed?

A

in the hematopoietic stem cells

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6
Q

T/F:
RBCs and platelets are formed in the marrow and released into circulation

A

True

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7
Q

Neutropenia:

A

-Not enough WBC
- Increase Infection

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8
Q

Felty Syndrome includes :

A

-Rheumatoid arthritis
- A swollen spleen
-Decreased white blood cell count
-repeated infections

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9
Q

What are WBC controlled by?

A

Multiple hematopoietic growth factors or inducers

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10
Q

What causes neutropenia?

A

Bacterial or fungal infections

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11
Q

The Infectious Mononucleosis is Also known as the ___?

A

Kissing Disease

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12
Q

What are symptoms of neutropenia?

A

*Malaise (discomfort)
*Chills
*Fever
*Extreme weakness and Fatigue

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13
Q

Infectious Mononucleosis:

A
  • a Self-limited lymphoproliferative disorder
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14
Q

What is a cause and characteristic of infectious Mononucleosis?

A
  • the Epstein Barr Virus EBV
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15
Q

What represents the most important white blood cell disorders?

A

Neoplastic Disorder of Hematopoietic and Lymphoid Origin

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16
Q

Epstein Barr Virus EBV is a member of what family

A
  • The Herpes Virus Family
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17
Q

Epstein Barr Virus EBV is transmitted by ?

A

Saliva

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18
Q

What is a neoplasm?

A

a new and abnormal growth of tissue in some part of the body, especially as a characteristic of cancer.

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19
Q

How does Hodgkin’s Disease Arise?

A

in a single node or chain of nodes

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20
Q

What is significant about Hodgkins disease and

A

Reed-Sternberg cells are present

21
Q

What determines neoplasms?

A

*Their site of origin
*The progenitor cell (like stem cells) from which they originated
* The molecular events involved in their transformation into malignant neoplasm

22
Q

What is leukemia?

A

Cancer of blood cells

23
Q

Reed -Sternberg Cells are:

A

large and abnormal lymphocyte

24
Q

Where do malignant neoplasms arise from?

A

The transformation of a single blood cell derived from hematopoietic stem cells

25
Q

Where does Non-Hodgkin Disease Originate?

A
  • At the extranodal sites and spreads to anatomically contiguous nodes
26
Q

T/F:
Reed-Sternberg cells are present in Non-Hodgkin disease

A

False

27
Q

Where are Reed- Sternberg cells are derived ?

A

B lymphocytes

28
Q

What are the Characteristics of Reed-Sternberg Cells?

A
  • atypical
    -mononuclear tumor cells
29
Q

How is leukemia classified?

A

According to cell lineage ( developmental history of a cell) and rate of growth

30
Q

What Stage of Hodgkin’s Lymphoma lacks Constitutional Symptoms ?

A

Stage A

31
Q

What Stage of
Hodgkin’s Lymphoma is causes significant weight loss, fevers, Pruritus, and night sweats.

A

Stage B

32
Q

Which two leukemia types involve immature lymphocytes and their progenitors in the bone marrow, the spleen, lymph nodes, CNS, and other tissue.

A

Acute lymphocytic leukemia and Chronic lymphocytic leukemia

33
Q

Which two leukemia types involve pluripotent myeloid stem cells in the bone marrow and interfere with the maturation of all blood?

A

Acute myelogenous leukemia and Chronic myelogenous leukemia

34
Q

What are the Stages of Non-Hodgkin’s Lymphoma ?

A
  • Low- grade lymphomas
  • Intermediate-grade Lymphomas
  • High-grade Lymphomas a
35
Q

Acute Leukemias Complications include:

A
  • Tumor lysis syndrome
    -Hyperuricemia
    -Blast crisis
    -Leukostasis
36
Q

What are leukemic cells?

A

Abnormal white blood cells

37
Q

Tumor lysis:

A

Large number of cancer cells die in a short amount of time & release their content in to the blood

38
Q

Hyperuricemia:

A

elevated uric acid level blood

39
Q

Blast Crisis:

A

Cells grow quickly and may have mutate in other cells

40
Q

Multiple Myeloma

A

cancer that forms in a white blood cell

41
Q

T/F
A plasmid cell is a TYPE of WBC

A

True

42
Q

What are the functions of leukemic cells and where are they located?

A

*Proliferate rapidly and have a long life span
*circulate in the blood stem

43
Q

What are sites involved in Multiple Myeloma?

A
  • Bone and Bone Marrow
  • Osteoclasts
44
Q

What leads to bone resorption and destruction in Multiple Myeloma?

A

Osteoclasts

45
Q

Hypercalcemia:

A

Increases calcium level

46
Q

What does the blood-brain barrier allow?

A

It allows vessels to tightly regulate the movement of ions, molecules, and leukemic cells

47
Q

T/F:
Pts with Multiple Myeloma are at risks for Pathologic Fractures

A

True

48
Q

What cells are common in Intermediate- grade and High -grade lymphoma?

A

B-cells and T-cells

49
Q

T/F:
Burkitt and Non burkitt lyphomas are a part of High grade lymphomas.

A

True

Patho Fall 22 (8 decks)

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