Chapter 24: Disorders of WBC and Lymphoid Tissue

Question 1

What elements form blood?

Answer 1

*Red Blood Cells
*Platelets
*WBC

Question 2

What makes up white blood cells?

Answer 2

*Granulocytes
*Monocyte and macrophage lineage
*Lymphocytes

Question 3

Hematopoiesis:

Answer 3

• The formation of blood cells

Question 4

What is the lifespan of WBC?

Answer 4

13-20 Days

Question 5

Where are hematopoiesis formed?

Answer 5

in the hematopoietic stem cells

Question 6

T/F:
RBCs and platelets are formed in the marrow and released into circulation

Answer 6

True

Question 7

Neutropenia:

Answer 7

-Not enough WBC
- Increase Infection

Question 8

Felty Syndrome includes :

Answer 8

-Rheumatoid arthritis
- A swollen spleen
-Decreased white blood cell count
-repeated infections

Question 9

What are WBC controlled by?

Answer 9

Multiple hematopoietic growth factors or inducers

Question 10

What causes neutropenia?

Answer 10

Bacterial or fungal infections

Question 11

The Infectious Mononucleosis is Also known as the ___?

Answer 11

Kissing Disease

Question 12

What are symptoms of neutropenia?

Answer 12

*Malaise (discomfort)
*Chills
*Fever
*Extreme weakness and Fatigue

Question 13

Infectious Mononucleosis:

Answer 13

• a Self-limited lymphoproliferative disorder

Question 14

What is a cause and characteristic of infectious Mononucleosis?

Answer 14

• the Epstein Barr Virus EBV

Question 15

What represents the most important white blood cell disorders?

Answer 15

Neoplastic Disorder of Hematopoietic and Lymphoid Origin

Question 16

Epstein Barr Virus EBV is a member of what family

Answer 16

• The Herpes Virus Family

Question 17

Epstein Barr Virus EBV is transmitted by ?

Answer 17

Saliva

Question 18

What is a neoplasm?

Answer 18

a new and abnormal growth of tissue in some part of the body, especially as a characteristic of cancer.

Question 19

How does Hodgkin’s Disease Arise?

Answer 19

in a single node or chain of nodes

Question 20

What is significant about Hodgkins disease and

Answer 20

Reed-Sternberg cells are present

Question 21

What determines neoplasms?

Answer 21

*Their site of origin
*The progenitor cell (like stem cells) from which they originated
* The molecular events involved in their transformation into malignant neoplasm

Question 22

What is leukemia?

Answer 22

Cancer of blood cells

Question 23

Reed -Sternberg Cells are:

Answer 23

large and abnormal lymphocyte

Question 24

Where do malignant neoplasms arise from?

Answer 24

The transformation of a single blood cell derived from hematopoietic stem cells

Question 25

Where does Non-Hodgkin Disease Originate?

Answer 25

- At the extranodal sites and spreads to anatomically contiguous nodes

Question 26

T/F: Reed-Sternberg cells are present in Non-Hodgkin disease

Answer 26

False

Question 27

Where are Reed- Sternberg cells are derived ?

Answer 27

B lymphocytes

Question 28

What are the Characteristics of Reed-Sternberg Cells?

Answer 28

- atypical -mononuclear tumor cells

Question 29

How is leukemia classified?

Answer 29

According to cell lineage ( developmental history of a cell) and rate of growth

Question 30

What Stage of Hodgkin's Lymphoma lacks Constitutional Symptoms ?

Answer 30

Stage A

Question 31

What Stage of Hodgkin's Lymphoma is causes significant weight loss, fevers, Pruritus, and night sweats.

Answer 31

Stage B

Question 32

Which two leukemia types involve immature lymphocytes and their progenitors in the bone marrow, the spleen, lymph nodes, CNS, and other tissue.

Answer 32

Acute lymphocytic leukemia and Chronic lymphocytic leukemia

Question 33

Which two leukemia types involve pluripotent myeloid stem cells in the bone marrow and interfere with the maturation of all blood?

Answer 33

Acute myelogenous leukemia and Chronic myelogenous leukemia

Question 34

What are the Stages of Non-Hodgkin's Lymphoma ?

Answer 34

- Low- grade lymphomas - Intermediate-grade Lymphomas - High-grade Lymphomas a

Question 35

Acute Leukemias Complications include:

Answer 35

- Tumor lysis syndrome -Hyperuricemia -Blast crisis -Leukostasis

Question 36

What are leukemic cells?

Answer 36

Abnormal white blood cells

Question 37

Tumor lysis:

Answer 37

Large number of cancer cells die in a short amount of time & release their content in to the blood

Question 38

Hyperuricemia:

Answer 38

elevated uric acid level blood

Question 39

Blast Crisis:

Answer 39

Cells grow quickly and may have mutate in other cells

Question 40

Multiple Myeloma

Answer 40

cancer that forms in a white blood cell

Question 41

T/F A plasmid cell is a TYPE of WBC

Answer 41

True

Question 42

What are the functions of leukemic cells and where are they located?

Answer 42

*Proliferate rapidly and have a long life span *circulate in the blood stem

Question 43

What are sites involved in Multiple Myeloma?

Answer 43

- Bone and Bone Marrow - Osteoclasts

Question 44

What leads to bone resorption and destruction in Multiple Myeloma?

Answer 44

Osteoclasts

Question 45

Hypercalcemia:

Answer 45

Increases calcium level

Question 46

What does the blood-brain barrier allow?

Answer 46

It allows vessels to tightly regulate the movement of ions, molecules, and leukemic cells

Question 47

T/F: Pts with Multiple Myeloma are at risks for Pathologic Fractures

Answer 47

True

Question 48

What cells are common in Intermediate- grade and High -grade lymphoma?

Answer 48

B-cells and T-cells

Question 49

T/F: Burkitt and Non burkitt lyphomas are a part of High grade lymphomas.

Answer 49

True